WD_REPEATS_REGION domain-containing protein.

TPR_REGION domain-containing protein; RNA polymerase II complex binding; SH2 domain binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation.

WD_REPEATS_REGION domain-containing protein.

Ctr9, isoform A; Ctr9 (Ctr9) encodes a highly conserved member of the polymerase-associated factor 1 complex, which controls a number of transcriptional and epigenetic processes. It is involved in the proliferation and terminal differentiation of the central nervous system.

WD_REPEATS_REGION domain-containing protein.

RNA polymerase II 33kD subunit; DNA-directed 5'-3' RNA polymerase activity; RNA polymerase II activity; protein dimerization activity; DNA binding. It is involved in the biological process described with: transcription by RNA polymerase II; cellular response to heat.

WD_REPEATS_REGION domain-containing protein.

RNA polymerase-associated protein Rtf1; Plays a role in transcription-coupled histone modification. Required for methylation of 'Lys-4' of histone H3. Plays a role in regulation of transcription. Required for maximal induction of heat- shock genes. Plays a role in Notch signaling in the wing margins.

WD_REPEATS_REGION domain-containing protein.

Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development; Belongs [...]

WD_REPEATS_REGION domain-containing protein.

FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]

WD_REPEATS_REGION domain-containing protein.

Hyrax, isoform A; Hyrax (hyx) encodes a protein recruited by signaling pathway specific transcriptional regulators such as the products of arm and ci and is important for the output of Wingless and Hedgehog pathways.

WD_REPEATS_REGION domain-containing protein.

Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By simi [...]

TPR_REGION domain-containing protein; RNA polymerase II complex binding; SH2 domain binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation.

WD_REPEATS_REGION domain-containing protein.

TPR_REGION domain-containing protein; RNA polymerase II complex binding; SH2 domain binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation.

Ctr9, isoform A; Ctr9 (Ctr9) encodes a highly conserved member of the polymerase-associated factor 1 complex, which controls a number of transcriptional and epigenetic processes. It is involved in the proliferation and terminal differentiation of the central nervous system.

TPR_REGION domain-containing protein; RNA polymerase II complex binding; SH2 domain binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation.

RNA polymerase II 33kD subunit; DNA-directed 5'-3' RNA polymerase activity; RNA polymerase II activity; protein dimerization activity; DNA binding. It is involved in the biological process described with: transcription by RNA polymerase II; cellular response to heat.

TPR_REGION domain-containing protein; RNA polymerase II complex binding; SH2 domain binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation.

RNA polymerase-associated protein Rtf1; Plays a role in transcription-coupled histone modification. Required for methylation of 'Lys-4' of histone H3. Plays a role in regulation of transcription. Required for maximal induction of heat- shock genes. Plays a role in Notch signaling in the wing margins.

TPR_REGION domain-containing protein; RNA polymerase II complex binding; SH2 domain binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation.

Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development; Belongs [...]

TPR_REGION domain-containing protein; RNA polymerase II complex binding; SH2 domain binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation.

FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]

TPR_REGION domain-containing protein; RNA polymerase II complex binding; SH2 domain binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation.

Hyrax, isoform A; Hyrax (hyx) encodes a protein recruited by signaling pathway specific transcriptional regulators such as the products of arm and ci and is important for the output of Wingless and Hedgehog pathways.

TPR_REGION domain-containing protein; RNA polymerase II complex binding; SH2 domain binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation.

Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By simi [...]

Ctr9, isoform A; Ctr9 (Ctr9) encodes a highly conserved member of the polymerase-associated factor 1 complex, which controls a number of transcriptional and epigenetic processes. It is involved in the proliferation and terminal differentiation of the central nervous system.

WD_REPEATS_REGION domain-containing protein.

Ctr9, isoform A; Ctr9 (Ctr9) encodes a highly conserved member of the polymerase-associated factor 1 complex, which controls a number of transcriptional and epigenetic processes. It is involved in the proliferation and terminal differentiation of the central nervous system.

TPR_REGION domain-containing protein; RNA polymerase II complex binding; SH2 domain binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of histone H3-K4 methylation.

Ctr9, isoform A; Ctr9 (Ctr9) encodes a highly conserved member of the polymerase-associated factor 1 complex, which controls a number of transcriptional and epigenetic processes. It is involved in the proliferation and terminal differentiation of the central nervous system.

Histone H3.3A; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular mach [...]

Ctr9, isoform A; Ctr9 (Ctr9) encodes a highly conserved member of the polymerase-associated factor 1 complex, which controls a number of transcriptional and epigenetic processes. It is involved in the proliferation and terminal differentiation of the central nervous system.

Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.