STRINGSTRING
Ir21a Ir21a iav iav Ir8a Ir8a Ir60a Ir60a Ir76b Ir76b Trpml Trpml Ir68a Ir68a Ir64a Ir64a Ir20a Ir20a CG11155 CG11155 Trpgamma Trpgamma Ir84a Ir84a Ir92a Ir92a Ir31a Ir31a Ir93a Ir93a Ir40a Ir40a Ir41a Ir41a Trpm Trpm nompC nompC Tpr2 Tpr2 Ir25a Ir25a TrpA1 TrpA1 GluRIB GluRIB PKD PKD nan nan Ir76a Ir76a Nmdar2 Nmdar2 Gr28b Gr28b betaTub56D betaTub56D Pkd2 Pkd2 GluRIIA GluRIIA Nmdar1 Nmdar1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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Ir21aIonotropic receptor 21a; Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in temperature (thermosensation). Together with Ir25a and Ir93a, mediates the response of the dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior ; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (842 aa)
iavInactive (iav) encodes a protein involved in the response to different stimuli such as startle, heat or sound; Belongs to the transient receptor (TC 1.A.4) family. (1123 aa)
Ir8aIonotropic receptor 8a (Ir8a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as a co-receptor together with ligand-specific IRs (in a probable heterotetrameric complex) to detect diverse organic acids; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (936 aa)
Ir60aIonotropic receptor 60a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (716 aa)
Ir76bIonotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit. (636 aa)
TrpmlTransient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation. (652 aa)
Ir68aIonotropic glutamate receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (704 aa)
Ir64aIonotropic receptor 64a (Ir64a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It is part of a broad-specificity acid sensor that mediates avoidance behavior. (859 aa)
Ir20aIonotropic receptor 20a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (563 aa)
CG11155FI01405p; Kainate selective glutamate receptor activity; signaling receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: ion transport; regulation of synaptic activity. (910 aa)
TrpgammaTransient receptor potential-gamma protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. (1188 aa)
Ir84aIonotropic receptor 84a (Ir84a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in detection of phenylacetic acid and controls male courtship behavior. (644 aa)
Ir92aIonotropic receptor 92a (Ir92a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in detection of ammonia and amines to mediate attraction behavior. (678 aa)
Ir31aIonotropic glutamate receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus involved in sensory perception. (648 aa)
Ir93aIonotropic receptor 93a; Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation) and humidity (hygrosensation). Together with Ir21a and Ir25a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior. Together with Ir25a and Ir40a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behav [...] (868 aa)
Ir40aIonotropic receptor 40a; Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in humidity (hygrosensation). Together with Ir25a and Ir93a, mediates the response of the hygrosensory sacculus neurons to changes in relative humidity and is required for dry detection behavior. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (732 aa)
Ir41aIonotropic receptor 41a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (648 aa)
TrpmTransient receptor potential cation channel trpm; Calcium channel mediating constitutive calcium ion entry. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. (2023 aa)
nompCNo mechanoreceptor potential C (nompC) encodes a pore-forming subunit for a mechanosensitive non-selective cation channel. It belongs to the TRP channel family and is expressed in peripheral sensory neurons. It senses gentle touch and regulates locomotion in larval body wall neurons. In the adult, the product of nompC is involved in hearing transduction in the Johnston's organ. (1761 aa)
Tpr2Tetratricopeptide repeat protein 2, isoform A; Heat shock protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding. (508 aa)
Ir25aIonotropic receptor 25a; Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection. Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b. Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool av [...] (947 aa)
TrpA1Transient receptor potential cation channel A1 (TrpA1) encodes a cation channel activated by warming and by reactive chemicals. Its roles include the control of thermotaxis at innocuous temperatures, as well as thermal and chemical nociception in response to noxious heat and chemical exposure. (1232 aa)
GluRIBGlutamate receptor IB, isoform B; Ionotropic glutamate receptor activity; signaling receptor activity; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity. It is involved in the biological process described with: cation transport. (1182 aa)
PKDProtein Kinase D (PKD) encodes a Ser/Thr kinase of the PKC family of Ca[2+]/calmodulin-dependent protein kinases. It regulates actin-dynamics by controlling the activity of the phosphatase encoded by ssh. (906 aa)
nanNanchung, isoform B; Nanchung (nan) encodes a member of the transient Receptor Potential (TRP) channel family. It is involved in the response to different stimuli such as startle, humidity or sound. (834 aa)
Ir76aIonotropic receptor 76a, isoform E; Olfactory receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: transmission of nerve impulse; detection of chemical stimulus involved in sensory perception of smell; detection of chemical stimulus involved in sensory perception. (646 aa)
Nmdar2NMDA receptor 2, isoform C; Ligand-gated ion channel activity; signaling receptor activity; NMDA glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity. (1083 aa)
Gr28bPutative gustatory receptor 28b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (470 aa)
betaTub56DTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
Pkd2Polycystic kidney disease 2 (Pkd2) encodes a calcium permeable cation channel of the transient receptor potential (TRP) family. Its roles include sperm motility, smooth muscle contraction, larval feeding behavior, detection of mechanical stimuli and cold nociception. (924 aa)
GluRIIAGlutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (907 aa)
Nmdar1Glutamate [NMDA] receptor subunit 1; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation. (997 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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