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Hex-C Hex-C Ilp6 Ilp6 Treh Treh Akh Akh ImpL2 ImpL2 Ilp3 Ilp3 Thor Thor Dsk Dsk SLC5A11 SLC5A11 Hnf4 Hnf4 sNPF sNPF Hug Hug PyK PyK tobi tobi boss boss Pglym78 Pglym78 RpL32 RpL32 CCHa1-R CCHa1-R CG6262 CG6262 Uba1 Uba1 Pgi Pgi sut3 sut3 Gr28b Gr28b AkhR AkhR CCHa1 CCHa1 KCNQ KCNQ Mondo Mondo elav elav NPF NPF Glut1 Glut1 Gr43a Gr43a upd2 upd2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Hex-CPhosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis. (454 aa)
Ilp6Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation. (107 aa)
TrehTrehalase (Treh) encodes an enzyme that hydrolyzes the the disaccharide trehalose to two molecules of glucose in either the cytoplasm or the extracellular space; Belongs to the glycosyl hydrolase 37 family. (596 aa)
AkhAdipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. (79 aa)
ImpL2Neural/ectodermal development factor IMP-L2; Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion. (267 aa)
Ilp3Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females. (120 aa)
Thor4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. (117 aa)
DskDrosulfakinin-0; Drosulfakinin-0 (DSK 0) plays diverse biological roles including regulating gut muscle contraction in adults but not in larvae; Belongs to the gastrin/cholecystokinin family. (141 aa)
SLC5A11Sodium/solute co-transporter-like 5A11 (SLC5A11) encodes a protein involved in behavioral response to nutrient; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (600 aa)
Hnf4Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. (732 aa)
sNPFShort neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. (281 aa)
HugProtein hugin; Probably has a role in larval molting; Belongs to the pyrokinin family. (191 aa)
PyKPyruvate kinase (PyK) encodes an enzyme involved in muscle development, glycolysis and glucose homeostasis; Belongs to the pyruvate kinase family. (533 aa)
tobiTarget of brain insulin; Hydrolase activity, hydrolyzing O-glycosyl compounds. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 31 family. (657 aa)
bossProtein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. (896 aa)
Pglym78Phosphoglyceromutase 78 (Pglym78) encodes an enzyme involved in myoblast fusion and somatic muscle development; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (255 aa)
RpL3260S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
CCHa1-RNeuropeptide CCHamide-1 receptor; Receptor for the neuropeptide CCHamide-1. Plays a role in the modulation of starvation-induced olfactory behavior where starved flies show increased responsiveness to food odorants, repellants and pheromones. (499 aa)
CG6262Trehalase; Alpha,alpha-trehalase activity. It is involved in the biological process described with: trehalose metabolic process. (1042 aa)
Uba1Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. (1191 aa)
PgiPhosphoglucose isomerase (Pgi) encodes an enzyme involved in glucose homeostasis. (558 aa)
sut3Sugar transporter 3, isoform A; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; glucose homeostasis; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (476 aa)
Gr28bPutative gustatory receptor 28b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (470 aa)
AkhRAdipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. (455 aa)
CCHa1Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. (182 aa)
KCNQKCNQ potassium channel, isoform F; KCNQ potassium channel (KCNQ) encodes a voltage-gated channel involved in cardiac muscle contraction; Belongs to the potassium channel family. (993 aa)
MondoMlx interactor alpha; Mondo (Mondo) encodes a basic helix-loop-helix-leucine zipper transcription factor involved in lipid and carbohydrate metabolism. Together with its binding partner encoded by bigmax, it controls sugar-dependent gene expression, including activation of genes involved in lipogenesis. Mondo mutants are intolerant to dietary sugars and have impaired muscle function. (1119 aa)
elavProtein elav; Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism. Belongs to the RRM elav family. (483 aa)
NPFNeuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] (102 aa)
Glut1Glucose transporter 1 (Glut1) encodes a transmembrane protein that transports glucose but not galactose. (1440 aa)
Gr43aGustatory receptor for sugar taste 43a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies. (453 aa)
upd2Unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes. (406 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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