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Ir25a Ir25a TrpA1 TrpA1 Ir8a Ir8a Grasp65 Grasp65 Orco Orco Gr63a Gr63a Csk Csk norpA norpA brp brp Rpt3 Rpt3 oc oc
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Ir25aIonotropic receptor 25a; Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection. Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b. Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool av [...] (947 aa)
TrpA1Transient receptor potential cation channel A1 (TrpA1) encodes a cation channel activated by warming and by reactive chemicals. Its roles include the control of thermotaxis at innocuous temperatures, as well as thermal and chemical nociception in response to noxious heat and chemical exposure. (1232 aa)
Ir8aIonotropic receptor 8a (Ir8a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as a co-receptor together with ligand-specific IRs (in a probable heterotetrameric complex) to detect diverse organic acids; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (936 aa)
Grasp65Grasp65 (Grasp65) encodes a myristoylated Golgi protein that binds the product of GM130 and has been shown to mediate the Golgi bypass of transmembrane proteins. (460 aa)
OrcoOdorant receptor coreceptor; Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-deriv [...] (486 aa)
Gr63aGustatory and odorant receptor 63a; Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a. (489 aa)
CskC-terminal Src kinase (Csk) encodes a cytoplasmic tyrosine kinase that acts as a tumor suppressor through Src pathway inibition as well as a mediator of the activity of the product of Egfr. (1052 aa)
norpA1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] (1095 aa)
brpBruchpilot, isoform J; Bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation. (2238 aa)
Rpt3Regulatory particle triple-A ATPase 3, isoform A; Proteasome-activating ATPase activity; ATPase activity; ATP binding. It is involved in the biological process described with: positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process; Belongs to the AAA ATPase family. (413 aa)
ocHomeotic protein ocelliless; Transcriptional regulator involved in pattern formation and cell determination in the embryonic CNS and larval imaginal disks. Also later in development to coordinate the expression of regulatory and structural genes required for photoreceptor cell fate in the ocelli. Has a dual role in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin (rh) expression: essential for establishing the expression of rh genes in the pale subset of ommatidia as well as repressing Rh6 in outer photoreceptors. Belongs to the paired homeobox family. (664 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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