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Hsp22 Hsp22 RpL22 RpL22 RpS6 RpS6 RpL29 RpL29 RpS24 RpS24 RpL12 RpL12 Rap2l Rap2l RpL19 RpL19 RpL8 RpL8 RpL28 RpL28 Gapdh2 Gapdh2 RpS17 RpS17 CG5144 CG5144 Argk Argk RpL14 RpL14 Ser12 Ser12 Rpn10 Rpn10 nrv2 nrv2 Send2 Send2 mRpL4 mRpL4 alpha-Est7 alpha-Est7 Droj2 Droj2 Ace Ace RpS5b RpS5b CG4546 CG4546 RpS20 RpS20 RpS27 RpS27 RpL4 RpL4 Gp93 Gp93 RpL32 RpL32 eEF1alpha2 eEF1alpha2 betaGlu betaGlu RpS18 RpS18 betaTub56D betaTub56D SdhA SdhA CG15117 CG15117 CG9010 CG9010 RpS15 RpS15 RpS23 RpS23 RpS11 RpS11 Gapdh1 Gapdh1 RpS8 RpS8 mt:ND2 mt:ND2 eIF4A eIF4A RpS2 RpS2 RpL27 RpL27 eEF1alpha1 eEF1alpha1 FoxK FoxK RpL18 RpL18 U2af38 U2af38 RpL40 RpL40 CG4757 CG4757 RpL3 RpL3 RpL9 RpL9 RpL11 RpL11 RpS9 RpS9 eIF2alpha eIF2alpha RpS5a RpS5a RpL7 RpL7 RpL5 RpL5 E2f1 E2f1 Achl Achl RpS3 RpS3 RpS13 RpS13 RpS26 RpS26 RpL26 RpL26 ras ras
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Hsp22Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. (174 aa)
RpL22Ribosomal protein L22 (RpL22) encodes a member of the eukaryotic ribosomal protein eL22 family. It is ubiquitously expressed, forms part of the large ribosomal subunit and is involved in protein synthesis. (299 aa)
RpS640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (248 aa)
RpL2960S ribosomal protein L29; Chromatin binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL29 family. (76 aa)
RpS24Ribosomal protein S24 (RpS24) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles; Belongs to the eukaryotic ribosomal protein eS24 family. (131 aa)
RpL12Ribosomal protein L12 (RpL12) encodes a protein of the large subunit of the ribosome. It regulates transcription of ribosomal proteins and ribosome biogenesis genes as well as interacting with the Enhancer of Trithorax and Polycomb protein encoded by corto. (165 aa)
Rap2lRas-associated protein 2-like, isoform A; GTP binding; GDP binding; GTPase activity. It is involved in the biological process described with: germ-line stem cell population maintenance; negative regulation of cell migration; Rap protein signal transduction. (182 aa)
RpL19Ribosomal protein L19 (RpL19) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL19 family. (203 aa)
RpL8Ribosomal protein L8 (RpL8) encodes a ribosomal structural constituent. (256 aa)
RpL2860S ribosomal protein L28; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the eukaryotic ribosomal protein eL28 family. (144 aa)
Gapdh2Glyceraldehyde 3 phosphate dehydrogenase 2 (Gapdh2) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glucose homeostasis; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
RpS17Ribosomal protein S17 (RpS17) encodes an essential component of the ribosomal 40S subunit. RpS17 mutants have dominant, haploinsufficient effects on cellular and organismal growth rate, and on bristle size; Belongs to the eukaryotic ribosomal protein eS17 family. (131 aa)
CG5144Uncharacterized protein; Kinase activity; creatine kinase activity. It is involved in the biological process described with: phosphocreatine biosynthetic process; Belongs to the ATP:guanido phosphotransferase family. (388 aa)
ArgkKinase activity; arginine kinase activity; creatine kinase activity. It is involved in the biological process described with: phosphocreatine biosynthetic process; phosphorylation; Belongs to the ATP:guanido phosphotransferase family. (562 aa)
RpL14Ribosomal protein L14 (RpL14) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL14 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. (166 aa)
Ser12Serine protease 12; Serine-type endopeptidase activity. It is involved in the biological process described with: wound healing; proteolysis; Belongs to the peptidase S1 family. (245 aa)
Rpn10Regulatory particle non-ATPase 10 (Rpn10) encodes one of the polyubiquitin receptor subunits of the 26S proteasome. It recognizes and binds the polyubiquitin moiety of proteins intended for proteasomal degradation or the ubiquitin-like domain of extraproteasomal ubiquitin receptors. (396 aa)
nrv2Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (323 aa)
Send2Spermathecal endopeptidase 2; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. (239 aa)
mRpL4Mitochondrial ribosomal protein L4; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; translation. (296 aa)
alpha-Est7alpha-Esterase-7 (alpha-Est7) encodes a carboxylic ester hydrolase involved in insecticide tolerance, lipid metabolism and lifespan control; Belongs to the type-B carboxylesterase/lipase family. (572 aa)
Droj2DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding. (403 aa)
AceAcetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. (649 aa)
RpS5b40S ribosomal protein S5b; rRNA binding; structural constituent of ribosome; mRNA binding. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation; Belongs to the universal ribosomal protein uS7 family. (230 aa)
CG4546GH24918p; Kinase activity; creatine kinase activity. It is involved in the biological process described with: multicellular organism reproduction; phosphocreatine biosynthetic process; Belongs to the ATP:guanido phosphotransferase family. (457 aa)
RpS2040S ribosomal protein S20; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation. (120 aa)
RpS2740S ribosomal protein S27; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation. (84 aa)
RpL460S ribosomal protein L4; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the universal ribosomal protein uL4 family. (401 aa)
Gp93Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. (787 aa)
RpL3260S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
eEF1alpha2Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
betaGluBeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (686 aa)
RpS18Ribosomal protein S18 (RpS18) encodes a ribosomal protein located at the top of the head of the 40S subunit and contacts several helices of the 18S rRNA. (152 aa)
betaTub56DTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
SdhASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders. (661 aa)
CG15117Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (670 aa)
CG9010Glyceraldehyde-3-phosphate dehydrogenase; Peptidyl-cysteine S-nitrosylase activity; NADP binding; NAD binding; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. It is involved in the biological process described with: oxidation-reduction process; glycolytic process; glucose metabolic process. (343 aa)
RpS15Ribosomal protein S15 (RpS15) encodes a protein that plays a role in assembly, structure and function of the ribosome and functions in protein synthesis. It is phosphorylated by the kinase encoded by Lrrk, causing protein synthesis upregulation; Belongs to the universal ribosomal protein uS19 family. (148 aa)
RpS2340S ribosomal protein S23; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (143 aa)
RpS1140S ribosomal protein S11; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uS17 family. (155 aa)
Gapdh1Glyceraldehyde 3 phosphate dehydrogenase 1 (Gapdh1) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glycolysis, myoblast fusion and the development of somatic muscle. (332 aa)
RpS8Ribosomal protein S8 (RpS8) encodes a structural constituent of ribosomes that is involved in larval lymph gland hemopoiesis; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
mt:ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (341 aa)
eIF4AEukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation. (403 aa)
RpS2Ribosomal protein S2 (RpS2) encodes a highly conserved component of the 40S ribolomal comlex. RpS2 product controls the assembly and nuclear export of the pre-ribosome and appears to have a specific function during oogenesis. (267 aa)
RpL2760S ribosomal protein L27; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL27 family. (135 aa)
eEF1alpha1Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (463 aa)
FoxKForkhead box K (FoxK) encodes a transcription factor in the Fork Head family. It is a direct target of Dpp/BMP signaling during midgut development, and in turn regulates the homeobox gene lab to determine endoderm differentiation. It also regulates antiviral gene expression. (760 aa)
RpL1860S ribosomal protein L18; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; translation. (188 aa)
U2af38U2 small nuclear riboprotein auxiliary factor 38 (U2af38) encodes the small subunit of the pre-mRNA splicing factor complex U2AF. This heterodimeric complex binds to the intron pyrimidine tract and targets the product of snf to the branch site early in spliceosome assembly. The U2af38 product binds to the AG dinucleotide at the 3' splice site. (264 aa)
RpL40Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
CG4757Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family. (550 aa)
RpL360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (416 aa)
RpL9Ribosomal protein L9 (RpL9) encodes a ribosomal structural constituent; Belongs to the universal ribosomal protein uL6 family. (190 aa)
RpL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (184 aa)
RpS9Ribosomal protein S9 (RpS9) encodes a structural constituent of ribosomes. (195 aa)
eIF2alphaEukaryotic translation initiation factor 2 subunit alpha (eIF2alpha) encodes one of three subunits of the eIF-2 complex required for the initiation of translation. eIF2alpha is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles. (341 aa)
RpS5aRibosomal protein S5a (RpS5a) encodes a structural constituent of ribosomes; Belongs to the universal ribosomal protein uS7 family. (228 aa)
RpL760S ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). (252 aa)
RpL560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (299 aa)
E2f1Transcription factor E2f1; Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg; Belongs to the E2F/DP family. (821 aa)
AchlAchilles, isoform A; Achilles (Achl) is a clock-controlled gene that is expressed in a rhythmic manner in the brain. It regulates wing development and expression of antimicrobial peptides. (867 aa)
RpS3Ribosomal protein S3 (RpS3) encodes a component of the small subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpS3 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. The product of RpS3 also contains a DNA lyase activity and functions in DNA repair. (246 aa)
RpS13Ribosomal protein S13 (RpS13) encodes a structural constituent of ribosomes; Belongs to the universal ribosomal protein uS15 family. (151 aa)
RpS2640S ribosomal protein S26; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation. (114 aa)
RpL26Ribosomal protein L26 (RpL26) encodes a protein component of large ribosomal subunits. (149 aa)
rasInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (590 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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