(7 nodes) (2018) Tissue-Specific cis-Regulatory Divergence Implicates eloF in Inhibiting Interspecies Mating in Drosophila. network (Drosophila melanogaster)

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	WASp	WASp, isoform A; WASp (WASp) encodes the homolog of the conserved Wiskott-Aldrich Syndrome family of nucleation promoting factors. It enables the Arp2/3 complex to nucleate polymerization of branched microfilament arrays. It contributes to gastrulation, myoblast fusion, synapse morphology at neuromuscular junctions, sensory organ development, and spermatogenesis. (527 aa)
	nopo	No poles (nopo) encodes a RING domain-containing E3 ubiquitin ligase that is essential for early embryogenesis. It positively regulates caspase-dependent cell death. (435 aa)
	lectin-22C	Lectin-22C; Galactose binding; carbohydrate binding. (263 aa)
	FASN3	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process. (2394 aa)
	Fad2	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones. (355 aa)
	CG8534	Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (265 aa)
	eloF	Elongation of very long chain fatty acids protein F; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis. (257 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG8534	FASN3	FBpp0081621	FBpp0297101	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process.	0.835
CG8534	Fad2	FBpp0081621	FBpp0075926	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones.	0.459
CG8534	eloF	FBpp0081621	FBpp0081622	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein F; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis.	0.455
CG8534	lectin-22C	FBpp0081621	FBpp0288953	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Lectin-22C; Galactose binding; carbohydrate binding.	0.670
FASN3	CG8534	FBpp0297101	FBpp0081621	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.835
FASN3	Fad2	FBpp0297101	FBpp0075926	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process.	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones.	0.658
FASN3	eloF	FBpp0297101	FBpp0081622	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process.	Elongation of very long chain fatty acids protein F; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis.	0.615
FASN3	lectin-22C	FBpp0297101	FBpp0288953	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process.	Lectin-22C; Galactose binding; carbohydrate binding.	0.533
Fad2	CG8534	FBpp0075926	FBpp0081621	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.459
Fad2	FASN3	FBpp0075926	FBpp0297101	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones.	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process.	0.658
Fad2	eloF	FBpp0075926	FBpp0081622	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones.	Elongation of very long chain fatty acids protein F; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis.	0.985
Fad2	lectin-22C	FBpp0075926	FBpp0288953	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones.	Lectin-22C; Galactose binding; carbohydrate binding.	0.459
eloF	CG8534	FBpp0081622	FBpp0081621	Elongation of very long chain fatty acids protein F; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.455
eloF	FASN3	FBpp0081622	FBpp0297101	Elongation of very long chain fatty acids protein F; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis.	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process.	0.615
eloF	Fad2	FBpp0081622	FBpp0075926	Elongation of very long chain fatty acids protein F; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis.	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones.	0.985
lectin-22C	CG8534	FBpp0288953	FBpp0081621	Lectin-22C; Galactose binding; carbohydrate binding.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.670
lectin-22C	FASN3	FBpp0288953	FBpp0297101	Lectin-22C; Galactose binding; carbohydrate binding.	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process.	0.533
lectin-22C	Fad2	FBpp0288953	FBpp0075926	Lectin-22C; Galactose binding; carbohydrate binding.	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones.	0.459