(14 nodes) (2019) Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. network (Drosophila melanogaster)

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	ELOVL	Elongation of very long chain fatty acids protein; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. (329 aa)
	CG16904	Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (262 aa)
	Desat1	Desaturase 1 (Desat1) encodes a transmembrane fatty acid desaturase that utilizes myristate and stearate (C16:0 and C18:0) to synthesize myristoleic and oleic acids (C16:1 and C18:1). It is involved in the synthesis of unsaturated fatty acids. (383 aa)
	Baldspot	Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis. (316 aa)
	Hnf4	Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. (732 aa)
	Rpt3	Regulatory particle triple-A ATPase 3, isoform A; Proteasome-activating ATPase activity; ATPase activity; ATP binding. It is involved in the biological process described with: positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process; Belongs to the AAA ATPase family. (413 aa)
	FASN1	Fatty acid synthase 1 (FASN1) encodes a fatty acid synthase involved in glycogen metabolism and triglyceride biosynthesis. (2540 aa)
	RpL13	Ribosomal protein L13 (RpL13) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL13 family. (218 aa)
	CG30008	Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (266 aa)
	nopo	No poles (nopo) encodes a RING domain-containing E3 ubiquitin ligase that is essential for early embryogenesis. It positively regulates caspase-dependent cell death. (435 aa)
	CG18609	Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (263 aa)
	RpL32	60S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
	Cyp4g1	Cytochrome P450-4g1 (Cyp4g1) encodes the terminal oxidative decarbonylase in cuticular hydrocarbon biosynthesis within oenocytes. (556 aa)
	Cpr	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5 (By similarity). May function to clear the olfactory organ (antennae) from accumulating chemicals. In the N-terminal section; belongs to the flavodoxin family. (679 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Baldspot	CG16904	FBpp0075114	FBpp0081632	Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.463
Baldspot	CG18609	FBpp0075114	FBpp0085825	Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.465
Baldspot	CG30008	FBpp0075114	FBpp0087468	Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.671
Baldspot	ELOVL	FBpp0075114	FBpp0081313	Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis.	Elongation of very long chain fatty acids protein; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.	0.628
Baldspot	FASN1	FBpp0075114	FBpp0307371	Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis.	Fatty acid synthase 1 (FASN1) encodes a fatty acid synthase involved in glycogen metabolism and triglyceride biosynthesis.	0.843
CG16904	Baldspot	FBpp0081632	FBpp0075114	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis.	0.463
CG16904	CG18609	FBpp0081632	FBpp0085825	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.712
CG16904	CG30008	FBpp0081632	FBpp0087468	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.939
CG16904	Cpr	FBpp0081632	FBpp0078880	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5 (By similarity). May function to clear the olfactory organ (antennae) from accumulating chemicals. In the N-terminal section; belongs to the flavodoxin family.	0.449
CG16904	Cyp4g1	FBpp0081632	FBpp0070094	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Cytochrome P450-4g1 (Cyp4g1) encodes the terminal oxidative decarbonylase in cuticular hydrocarbon biosynthesis within oenocytes.	0.884
CG16904	Desat1	FBpp0081632	FBpp0082096	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Desaturase 1 (Desat1) encodes a transmembrane fatty acid desaturase that utilizes myristate and stearate (C16:0 and C18:0) to synthesize myristoleic and oleic acids (C16:1 and C18:1). It is involved in the synthesis of unsaturated fatty acids.	0.446
CG16904	ELOVL	FBpp0081632	FBpp0081313	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.	0.467
CG18609	Baldspot	FBpp0085825	FBpp0075114	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis.	0.465
CG18609	CG16904	FBpp0085825	FBpp0081632	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.712
CG18609	CG30008	FBpp0085825	FBpp0087468	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.832
CG18609	Cyp4g1	FBpp0085825	FBpp0070094	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Cytochrome P450-4g1 (Cyp4g1) encodes the terminal oxidative decarbonylase in cuticular hydrocarbon biosynthesis within oenocytes.	0.774
CG18609	Desat1	FBpp0085825	FBpp0082096	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Desaturase 1 (Desat1) encodes a transmembrane fatty acid desaturase that utilizes myristate and stearate (C16:0 and C18:0) to synthesize myristoleic and oleic acids (C16:1 and C18:1). It is involved in the synthesis of unsaturated fatty acids.	0.544
CG18609	ELOVL	FBpp0085825	FBpp0081313	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.	0.529
CG30008	Baldspot	FBpp0087468	FBpp0075114	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis.	0.671
CG30008	CG16904	FBpp0087468	FBpp0081632	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.939