STRINGSTRING
Act5C Act5C Act57B Act57B dsh dsh cyc cyc rt rt Cp18 Cp18 Vm34Ca Vm34Ca hll hll Act88F Act88F Keap1 Keap1 Arc1 Arc1 tum tum Cyp4p2 Cyp4p2 Mal-A4 Mal-A4 Mal-A3 Mal-A3 Clk Clk fz3 fz3 Msp300 Msp300 foxo foxo fz fz put put CASK CASK Sclp Sclp Mtor Mtor fln fln LamC LamC Vm26Aa Vm26Aa rdgA rdgA Gclc Gclc Mlp60A Mlp60A hbs hbs Mal-A7 Mal-A7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Act5CActin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
Act57BActin-57B; Actin 57B (Act57B) is one of several actin genes in the Drosophila genome, and one of the few that encode myofibrillar actin. This essential gene is a transcriptional target of Mef2 and Cf2 and is expressed in all embryonic muscles and a subset of adult muscle. (376 aa)
dshSegment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. (623 aa)
cycProtein cycle; Putative transcription factor involved in the generation of biological rhythms. Activates cycling transcription of Period (PER) and Timeless (TIM) by binding to the E-box (5'-CACGTG-3') present in their promoters. (413 aa)
rtProtein O-mannosyltransferase 1; Rotated abdomen (rt) encodes a protein that transfers a mannose to the Ser/Thr residues of the product of Dg, via forming an heterodimer with the product of tw. Its roles include myogenesis, muscle architecture and cell adhesion. (886 aa)
Cp18Chorion protein S18; Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment; Belongs to the chorion protein S15/S18 family. (172 aa)
Vm34CaVitelline membrane protein Vm34Ca; Major early eggshell protein; Belongs to the vitelline membrane protein family. (119 aa)
hllLong-chain-fatty-acid--CoA ligase heimdall; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function ; Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. (681 aa)
Act88FActin, indirect flight muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Required for proper formation of indirect flight muscle (IFM) myofibrils; Belongs to the actin family. (376 aa)
Keap1Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. (776 aa)
Arc1Activity-regulated cytoskeleton associated protein 1; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles. Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation. Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction. May play a role in energy balance: required for regulation of body fat b [...] (254 aa)
tumTumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation. (625 aa)
Cyp4p2Probable cytochrome P450 4p2; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (520 aa)
Mal-A4Maltase A4; Maltose alpha-glucosidase activity. It is involved in the biological process described with: carbohydrate metabolic process. (579 aa)
Mal-A3Maltase A3; Maltose alpha-glucosidase activity. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 13 family. (574 aa)
ClkCircadian locomoter output cycles protein kaput; Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced [...] (1027 aa)
fz3Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (646 aa)
Msp300Muscle-specific protein 300 kDa (Msp300) encodes a Nesprin-like protein that is required for proper positioning of muscle nuclei, mitochondria, and neuromuscular junction. (13540 aa)
foxoForkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa)
fzFrizzled; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to inv [...] (612 aa)
putSerine/threonine-protein kinase receptor; Punt (put) encodes a transforming growth factor beta type II receptor that functions in both Dpp/BMP and Activin signaling. Pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with the product of put; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (520 aa)
CASKPeripheral plasma membrane protein CASK; CASK (CASK) encodes a member of the MAGUK family of scaffolding proteins. In epithelial tissues, the product of CASK functions as an adhesion molecule involved in cell proliferation, cytoskeletal remodeling and cell migration. In neurons, the product of CASK serves as a scaffold for a number of signaling and transmembrane molecules and is involved in synaptic development and plasticity. (929 aa)
SclpSclp, isoform C; It is involved in the biological process described with: muscle system process. (339 aa)
MtorNucleoprotein TPR; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome. Associates with extended chromosomal regions that alternate between domains of high density binding with those of lo [...] (2346 aa)
flnFlightin (fln) encodes an indirect flight muscle specific protein, not expressed in other muscle types. It is required for the correct assembly of the myosin thick filament during flight muscle development in pupae. fln null mutants cannot fly and show a progressive flight muscle loss as adults. This loss is most likely caused by uncontrolled hypercontraction. (182 aa)
LamCLamin-C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (By similarity). In spermatocytes, regulates cytokinesis during meiosis. (640 aa)
Vm26AaVitelline membrane protein Vm26Aa; Major early eggshell protein; Belongs to the vitelline membrane protein family. (141 aa)
rdgARetinal degeneration A (rdgA) encodes a diacylglycerol kinase that mediates the conversion of diacylglycerol to phosphatidic acid. It contributes to phospholipase C based signalling reactions, controlling ion channel activity and protein transport. (1462 aa)
GclcGlutamate-cysteine ligase catalytic subunit (Gclc) encodes a heterodimeric enzyme involved in the first rate-limiting step of glutathione synthesis. It binds L-cysteine and L-glutamate to form gamma-glutamylcysteine; Belongs to the glutamate--cysteine ligase type 3 family. (717 aa)
Mlp60AMuscle LIM protein at 60A (Mlp60A) encodes a Zinc-ion binding protein, expressed strongly in the Z-band region of the sarcomere. It is involved in development and maintenance of the embryonic and flight muscles. (486 aa)
hbsHibris, isoform B; Hibris (hbs) encodes a Ig repeat transmembrane protein with a fibronectin type III domain. It functions as a receptor involved in muscle cell fusion. (1235 aa)
Mal-A7Maltase A7, isoform A; Maltose alpha-glucosidase activity. It is involved in the biological process described with: carbohydrate metabolic process. (599 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.