node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arl8 | Mtl | FBpp0308780 | FBpp0084562 | ADP-ribosylation factor-like protein 8; Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion. Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes. In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. Essential role in chromosome segregation. | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. | 0.629 |
Arl8 | unc-13 | FBpp0308780 | FBpp0300963 | ADP-ribosylation factor-like protein 8; Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion. Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes. In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. Essential role in chromosome segregation. | Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis. | 0.445 |
GluRIIA | GluRIIC | FBpp0078739 | FBpp0307912 | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. | Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. | 0.835 |
GluRIIA | Rab3 | FBpp0078739 | FBpp0087352 | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. | 0.440 |
GluRIIA | Syn | FBpp0078739 | FBpp0099901 | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. | Synapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. | 0.626 |
GluRIIA | Syt1 | FBpp0078739 | FBpp0077410 | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. | Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. | 0.679 |
GluRIIA | VGlut | FBpp0078739 | FBpp0303629 | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. | Vesicular glutamate transporter, isoform A. | 0.791 |
GluRIIA | brp | FBpp0078739 | FBpp0293597 | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. | Bruchpilot, isoform J; Bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation. | 0.912 |
GluRIIA | cac | FBpp0078739 | FBpp0423194 | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. | Voltage-dependent calcium channel type A subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine- insensitive current. Vital for survival to adulthood. | 0.679 |
GluRIIA | unc-13 | FBpp0078739 | FBpp0300963 | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. | Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis. | 0.432 |
GluRIIC | GluRIIA | FBpp0307912 | FBpp0078739 | Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. | 0.835 |
GluRIIC | Rab3 | FBpp0307912 | FBpp0087352 | Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. | 0.516 |
GluRIIC | Syn | FBpp0307912 | FBpp0099901 | Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. | Synapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. | 0.668 |
GluRIIC | Syt1 | FBpp0307912 | FBpp0077410 | Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. | Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. | 0.680 |
GluRIIC | VGlut | FBpp0307912 | FBpp0303629 | Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. | Vesicular glutamate transporter, isoform A. | 0.870 |
GluRIIC | brp | FBpp0307912 | FBpp0293597 | Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. | Bruchpilot, isoform J; Bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation. | 0.914 |
GluRIIC | cac | FBpp0307912 | FBpp0423194 | Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. | Voltage-dependent calcium channel type A subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine- insensitive current. Vital for survival to adulthood. | 0.734 |
Mtl | Arl8 | FBpp0084562 | FBpp0308780 | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. | ADP-ribosylation factor-like protein 8; Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion. Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes. In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. Essential role in chromosome segregation. | 0.629 |
Rab3 | GluRIIA | FBpp0087352 | FBpp0078739 | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. | 0.440 |
Rab3 | GluRIIC | FBpp0087352 | FBpp0307912 | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. | Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. | 0.516 |