STRINGSTRING
His3:CG31613 His3:CG31613 SmD1 SmD1 Clp Clp Wdr33 Wdr33 Sym Sym SmE SmE Lsm11 Lsm11 Cpsf160 Cpsf160 SmB SmB His3.3A His3.3A Lsm10 Lsm10 SmD3 SmD3 PCB PCB His2A:CG31618 His2A:CG31618 Slbp Slbp Cpsf100 Cpsf100 Cpsf73 Cpsf73 CstF64 CstF64 SmD2 SmD2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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His3:CG31613Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
SmD1Small ribonucleoprotein particle protein SmD1 (SmD1) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD2. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. (124 aa)
ClpCleavage and polyadenylation specificity factor subunit 4; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity. Binds RNA polymers with a preference for G- and/or C-rich clusters. Binds single-stranded DNA non-specifically. (296 aa)
Wdr33WD repeat domain 33, isoform A; It is involved in the biological process described with: mRNA polyadenylation. (807 aa)
SymSymplekin (Sym) encodes a large protein that contains many protein interaction sites, and acts as a scaffold for protein complexes in the nucleus. It functions in RNA 3' end formation for both polyadenyated mRNAs and non-polyadenylated histone mRNAs. In some cells it also localizes to the cell cortex, especially the tricellular junctions of some epithelia. (1165 aa)
SmESmall ribonucleoprotein particle protein SmE (SmE) encodes an RNA binding protein that functions as part of a heteroheptameric ring structure called the Sm core. This complex binds to spliceosomal small nuclear RNAs (e.g. U1, U2, U4 and U5) and helps to carry out pre-mRNA splicing. It also forms a heterotrimeric sub-complex with the products of SmF and SNRPG. (94 aa)
Lsm11FI05704p; Lsm11 (Lsm11) encodes one of the seven proteins that form a heptameric Sm ring in the U7 snRNP, which is a key factor involved in 3' end processing of histone pre-mRNAs. It interacts with the product of FLASH. The two interacting proteins form a biochemical platform that recruits a number of polyadenylation subunits to the U7 snRNP, including the products of Sym, Cpsf100, Cpsf73 and CstF64. (256 aa)
Cpsf160Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. (1455 aa)
SmBSmall ribonucleoprotein particle protein SmB (SmB) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD3. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing; Belongs to the snRNP SmB/SmN family. (199 aa)
His3.3AHistone H3.3A; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular mach [...] (136 aa)
Lsm10Lsm10 (Lsm10) encodes a core component of the U7 snRNP complex, which functions in 3' end processing of the non-polyadenylated, replication-dependent histone mRNAs. The product of Lsm10 is part of the heptameric Sm ring complex that binds directly to U7 snRNA. It replaces the protein encoded by SmD1 in the canonical heptameric Sm protein ring that binds spliceosomal snRNAs. (141 aa)
SmD3Small ribonucleoprotein particle protein SmD3 (SmD3) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmB. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. The product of SmD3 also has a function in germline specification, as it is required for localization of the product of osk to the posterior pole of the oocyte. (151 aa)
PCBPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1197 aa)
His2A:CG31618Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
SlbpHistone RNA hairpin-binding protein; Stem-loop binding protein (Slbp) encodes a protein that plays an essential role in 3' end processing of histone pre-mRNAs into mature histone mRNAs by recruiting the product of snRNA:U7 to the pre-mRNA. (276 aa)
Cpsf100Probable cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'- ends of polyadenylated and histone pre-mRNA. (756 aa)
Cpsf73Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] (684 aa)
CstF64Cleavage stimulation factor 64 kD subunit (CstF64) encodes an RNA-binding protein that is part of the cleavage stimulation factor (CstF) complex. As part of the CstF complex, it interacts with the polyadenylation protein encoded bysu(f). The product of CstF64 is necessary for the cleavage and polyadenylation of most mRNAs and for 3' end processing of mRNAs that encode the replication-dependent histones. (419 aa)
SmD2Small ribonucleoprotein particle protein SmD2 (SmD2) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmD1. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. (119 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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