node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CarT | Hdc | FBpp0080925 | FBpp0311591 | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | 0.837 |
CarT | e | FBpp0080925 | FBpp0083505 | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity. | 0.839 |
CarT | lovit | FBpp0080925 | FBpp0312363 | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Uncharacterized protein; Sucrose:proton symporter activity. | 0.605 |
Ddc | Tbh | FBpp0080710 | FBpp0089042 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | Tyramine beta-hydroxylase; Converts tyramine into octopamine, a neurotransmitter involved in ovulation and locomotion. Functions in an amine-mediated Bacc-dependent signaling pathway that negatively regulates acute ethanol sensitivity. Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.969 |
Ddc | Tdc2 | FBpp0080710 | FBpp0085475 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | Tyrosine decarboxylase activity; carboxy-lyase activity; pyridoxal phosphate binding. It is involved in the biological process described with: oviposition; locomotor rhythm; behavioral response to cocaine; cellular amino acid metabolic process; locomotory behavior. | 0.907 |
Ddc | VAChT | FBpp0080710 | FBpp0083086 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | Vesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.509 |
Ddc | Vmat | FBpp0080710 | FBpp0090962 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | Vesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles. | 0.906 |
Ddc | e | FBpp0080710 | FBpp0083505 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity. | 0.864 |
Ddc | shps | FBpp0080710 | FBpp0083984 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | AT01267p; Oxidoreductase activity. It is involved in the biological process described with: oxidation-reduction process. | 0.943 |
GluClalpha | VAChT | FBpp0310353 | FBpp0083086 | Glutamate-gated chloride channel; Glutamate-gated chloride channel subunit. Glutamate binding triggers a rapidly reversible current, while the anti-helmintic drug ivermectin triggers a permanently open channel configuration. | Vesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.496 |
GluClalpha | VGAT | FBpp0310353 | FBpp0086703 | Glutamate-gated chloride channel; Glutamate-gated chloride channel subunit. Glutamate binding triggers a rapidly reversible current, while the anti-helmintic drug ivermectin triggers a permanently open channel configuration. | Vesicular GABA Transporter (VGAT) encodes an essential transporter that is responsible for packaging the neurotransmitter GABA into synaptic vesicles. | 0.547 |
GluClalpha | VGlut | FBpp0310353 | FBpp0303629 | Glutamate-gated chloride channel; Glutamate-gated chloride channel subunit. Glutamate binding triggers a rapidly reversible current, while the anti-helmintic drug ivermectin triggers a permanently open channel configuration. | Vesicular glutamate transporter, isoform A. | 0.699 |
Hdc | CarT | FBpp0311591 | FBpp0080925 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.837 |
Hdc | Tbh | FBpp0311591 | FBpp0089042 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Tyramine beta-hydroxylase; Converts tyramine into octopamine, a neurotransmitter involved in ovulation and locomotion. Functions in an amine-mediated Bacc-dependent signaling pathway that negatively regulates acute ethanol sensitivity. Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.502 |
Hdc | VAChT | FBpp0311591 | FBpp0083086 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Vesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.413 |
Hdc | Vmat | FBpp0311591 | FBpp0090962 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Vesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles. | 0.539 |
Hdc | e | FBpp0311591 | FBpp0083505 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity. | 0.701 |
Hdc | lovit | FBpp0311591 | FBpp0312363 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Uncharacterized protein; Sucrose:proton symporter activity. | 0.740 |
Tbh | Ddc | FBpp0089042 | FBpp0080710 | Tyramine beta-hydroxylase; Converts tyramine into octopamine, a neurotransmitter involved in ovulation and locomotion. Functions in an amine-mediated Bacc-dependent signaling pathway that negatively regulates acute ethanol sensitivity. Belongs to the copper type II ascorbate-dependent monooxygenase family. | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | 0.969 |
Tbh | Hdc | FBpp0089042 | FBpp0311591 | Tyramine beta-hydroxylase; Converts tyramine into octopamine, a neurotransmitter involved in ovulation and locomotion. Functions in an amine-mediated Bacc-dependent signaling pathway that negatively regulates acute ethanol sensitivity. Belongs to the copper type II ascorbate-dependent monooxygenase family. | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | 0.502 |