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Rcc1 Rcc1 Mst77F Mst77F ProtB ProtB ProtA ProtA RanGAP RanGAP bam bam His1:CG31617 His1:CG31617 His1:CG33801 His1:CG33801 His1:CG33807 His1:CG33807 His1:CG33834 His1:CG33834 His1:CG33855 His1:CG33855
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rcc1Regulator of chromosome condensation 1 (Rcc1) encodes the guanine-nucleotide exchange factor for the product of Ran. It promotes the nucleo-cytoplasmic shuttling of specific proteins and regulates chromatin condensation. The roles of Rcc1 product include cell proliferation, cell survival, apoptosis, epigenetic regulation, and neuronal specification. (547 aa)
Mst77FHistone-like protein 18C; Not known. Encoded in the intron of cAMP-dependent protein kinase regulatory chain type I. (215 aa)
ProtBProtamine B (ProtB) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines. (144 aa)
ProtAProtamine A (ProtA) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines. (146 aa)
RanGAPRan GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] (596 aa)
bamBag of marbles (bam) encodes a protein involved in gametogenesis that is associated with the fusome, a germ cell-specific organelle. It contributes to the fate determination of germline stem cells, in which bam is negatively regulated by the BMP signaling pathway. (442 aa)
His1:CG31617Histone H1; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (256 aa)
His1:CG33801Histone H1; Nucleosomal DNA binding; double-stranded DNA binding; chromatin DNA binding. (256 aa)
His1:CG33807Histone H1; Nucleosomal DNA binding; double-stranded DNA binding; chromatin DNA binding. (256 aa)
His1:CG33834Histone H1; Double-stranded DNA binding; chromatin DNA binding; nucleosomal DNA binding. (256 aa)
His1:CG33855Histone H1; Chromatin DNA binding. It is involved in the biological process described with: nucleosome assembly. (256 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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