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Gr64a Gr64a Gr64f Gr64f ppk28 ppk28 ninaE ninaE trpl trpl Plc21C Plc21C Ir21a Ir21a Gr66a Gr66a norpA norpA TrpA1 TrpA1 Ir25a Ir25a Ir93a Ir93a Rh5 Rh5 Rpt3 Rpt3 Tmc Tmc Rh6 Rh6 Gr5a Gr5a
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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Gr64aGustatory receptor for sugar taste 64a; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily. (456 aa)
Gr64fGustatory receptor for sugar taste 64f; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64a to detect sucrose, maltose, and glucose. (469 aa)
ppk28Pickpocket protein 28; Osmosensitive ion channel that mediates the cellular and behavioral response to water. Plays an essential role in gustatory water reception. Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (606 aa)
ninaEOpsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. (373 aa)
trplTransient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. (1124 aa)
Plc21C1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1318 aa)
Ir21aIonotropic receptor 21a; Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in temperature (thermosensation). Together with Ir25a and Ir93a, mediates the response of the dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior ; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (842 aa)
Gr66aGustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...] (527 aa)
norpA1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] (1095 aa)
TrpA1Transient receptor potential cation channel A1 (TrpA1) encodes a cation channel activated by warming and by reactive chemicals. Its roles include the control of thermotaxis at innocuous temperatures, as well as thermal and chemical nociception in response to noxious heat and chemical exposure. (1232 aa)
Ir25aIonotropic receptor 25a; Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection. Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b. Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool av [...] (947 aa)
Ir93aIonotropic receptor 93a; Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation) and humidity (hygrosensation). Together with Ir21a and Ir25a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior. Together with Ir25a and Ir40a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behav [...] (868 aa)
Rh5Rhodopsin 5 (Rh5) encodes a visual GPCR opsin that covalently binds the chromophore retinal. A photon of light stimulates the isomerization of retinal resulting in a conformational change in the product of Rh5 and signal activation. Its peak sensitivity is in the blue and it is expressed in a subclass of R8 photoreceptors; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (382 aa)
Rpt3Regulatory particle triple-A ATPase 3, isoform A; Proteasome-activating ATPase activity; ATPase activity; ATP binding. It is involved in the biological process described with: positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process; Belongs to the AAA ATPase family. (413 aa)
TmcTransmembrane channel-like (Tmc) encodes a protein involved in proprioception and locomotory behavior in larvae. (2036 aa)
Rh6Opsin Rh6; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (362 aa)
Gr5aGustatory receptor 5a for trehalose; Gustatory receptor required for response to the sugar trehalose in taste neurons. Gr5a neurons selectively respond to sugars, in contrast to Gr66a cells which respond to bitter compounds. Flies are attracted to sugars and avoid bitter substances, suggesting that Gr5a neuron activity is sufficient to mediate acceptance behavior. Sugar signal transduction occurs through coupling with G-proteins such as Galpha49B and G-salpha60A. (444 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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