STRINGSTRING
Sox21a Sox21a VGlut VGlut Rfx Rfx unc-4 unc-4 otp otp Ets65A Ets65A CG14989 CG14989 Ptx1 Ptx1 Mef2 Mef2 Rpb3 Rpb3 Dfd Dfd abd-A abd-A hbn hbn Gad1 Gad1 lic lic acj6 acj6 arx arx HGTX HGTX VAChT VAChT Tdc2 Tdc2 CG13739 CG13739 ChAT ChAT Vmat Vmat Dll Dll nAChRalpha4 nAChRalpha4 AttB AttB CG4328 CG4328 slpr slpr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Sox21aSox21a, isoform B; Sox21a (Sox21a) encodes a Sox family transcription factor involved in the differentiation of stem cells in the midgut. (407 aa)
VGlutVesicular glutamate transporter, isoform A. (632 aa)
RfxRfx, isoform H; Rfx (Rfx) encodes a transcription factor involved in the differentiation of ciliated sensory neurons. (919 aa)
unc-4Homeobox protein unc-4; Unc-4 (unc-4) encodes a homeodomain transcription factor expressed in distinct subsets of neurons in the embryonic and post-embryonic CNS. It regulates neuronal development and differentiation at least in part via repressing the expression of HGTX. It contributes to neuronal specification and differentiation, specifically axonal pathfinding and axongenesis. (588 aa)
otpHomeobox protein orthopedia; May be involved in the development of the central nervous system; Belongs to the paired homeobox family. Bicoid subfamily. (416 aa)
Ets65ADNA-binding protein D-ETS-3; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; cell differentiation; regulation of transcription by RNA polymerase II; Belongs to the ETS family. (728 aa)
CG14989IP21828p. (246 aa)
Ptx1Ptx1 (Ptx1) encodes a paired-like homeobox transcription factor expressed during embryogenesis and in the adult digestive tract. It is strongly expressed in the middle midgut (copper cell region) where it is required for local stem cell quiescence and proper function of this region. (610 aa)
Mef2Myocyte-specific enhancer factor 2; Transcription factor that could be a key player in early mesoderm differentiation and may be required for subsequent cell fate specifications within the somatic and visceral/heart mesodermal layers. Essential for myoblast fusion and consequently muscle formation in adults. During embryonic and pupal development, binds to the enhancer of the myoblast fusion gene sing and activates its transcription. Belongs to the MEF2 family. (606 aa)
Rpb3RNA polymerase II 33kD subunit; DNA-directed 5'-3' RNA polymerase activity; RNA polymerase II activity; protein dimerization activity; DNA binding. It is involved in the biological process described with: transcription by RNA polymerase II; cellular response to heat. (275 aa)
DfdHomeotic protein deformed; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Homeotic protein controlling Drosophila head development. Transcriptional activator of the apoptotic activator protein rpr in cells at the maxillary/mandibular boundary; Belongs to the Antp homeobox family. Deformed subfamily. (586 aa)
abd-AHomeobox protein abdominal-A; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for segmental identity of the second through eighth abdominal segments. Once a pattern of abd-A expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments. Appears to repress expression of Ubx whenever they appear in the same cell, but abd-A is repressed [...] (590 aa)
hbnHomeobrain; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated. (409 aa)
Gad1Glutamic acid decarboxylase 1 (Gad1) encodes an essential, nervous system-specific glutamic acid decarboxylase, which is the synthetic enzyme for the major inhibitory neurotransmitter gamma-Aminobutyric acid (GABA). It is required for a multitude of physiological functions and adult behaviors dependent on GABA, including sleep, memory, circadian rhythms and egg hatching; Belongs to the group II decarboxylase family. (510 aa)
licLicorne (lic) encodes a serine/threonine kinase that phosphorylates p38 MAP kinases. (334 aa)
acj6Inhibitory POU protein; Modulates gene transcription; simultaneously generates both a specific activator and an inhibitor of gene transcription, capable of modulating two distinct regulatory programs during neural development. Has a role in olfactory behavior; Belongs to the POU transcription factor family. Class-4 subfamily. (396 aa)
arxGametocyte-specific factor 1 homolog; Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons. Required for repression of transposons and neighboring genes in ovarian somatic and germline cells. (167 aa)
HGTXGTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. (513 aa)
VAChTVesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family. (578 aa)
Tdc2Tyrosine decarboxylase activity; carboxy-lyase activity; pyridoxal phosphate binding. It is involved in the biological process described with: oviposition; locomotor rhythm; behavioral response to cocaine; cellular amino acid metabolic process; locomotory behavior. (637 aa)
CG13739Uncharacterized protein; Chromatin binding. It is involved in the biological process described with: regulation of gene expression. (875 aa)
ChATCholine O-acetyltransferase 13 kDa chain; Choline acetyltransferase (ChAT) encodes a protein that catalyzes the biosynthesis of the neurotransmitter acetylcholine. It is considered to be a specific marker for cholinergic neurons. (721 aa)
VmatVesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles. (646 aa)
DllHomeotic protein distal-less; Transcription factor that plays a role in larval and adult appendage development. Specifies the identity of ventral appendages (including legs and antennae) and suppresses dorsal appendage development. Involved in patterning the distal-proximal limb axis. May control the adhesive properties of cells during limb morphogenesis. Also has a secondary role in the normal patterning of the wing margin. (347 aa)
nAChRalpha4Nicotinic Acetylcholine Receptor alpha4 (nAChRalpha4) encodes a four-pass transmembrane channel that is part of a nicotinic acetycholine receptor complex. It promotes sleep and its expression level peaks when sleep need is high. Its activity is inhibited by the product of qvr. (539 aa)
AttBAttacin-B (AttB) encodes an immune inducible peptide that shows homology to antibacterial peptides having activity against Gram-negative bacteria; Belongs to the attacin/sarcotoxin-2 family. (218 aa)
CG4328FI06571p; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; neuron differentiation. (544 aa)
slprMitogen-activated protein kinase kinase kinase; Activates the JUN N-terminal pathway during dorsal closure. (1155 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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