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Hex-t1 Hex-t1 dhd dhd Menl-1 Menl-1 Men-b Men-b Hex-C Hex-C Hsp60C Hsp60C MME1 MME1 Trx-2 Trx-2 Hsp60D Hsp60D Men Men His4r His4r Mdh2 Mdh2 CCAP CCAP Hex-t2 Hex-t2 TrxT TrxT Hex-A Hex-A CG13473 CG13473 CG10749 CG10749 CG10748 CG10748 colt colt Hsp60B Hsp60B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Hex-t1Hexokinase type 1; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (465 aa)
dhdThioredoxin-1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. Required for female meiosis and early embryonic development. (107 aa)
Menl-1Malic enzyme; Malate dehydrogenase (decarboxylating) (NAD+) activity; malate dehydrogenase (decarboxylating) (NADP+) activity; NAD binding; malic enzyme activity. It is involved in the biological process described with: pyruvate metabolic process; oxidation-reduction process; malate metabolic process. (610 aa)
Men-bMalic enzyme activity; malate dehydrogenase (decarboxylating) (NADP+) activity; malate dehydrogenase (decarboxylating) (NAD+) activity; NAD binding. It is involved in the biological process described with: oxidation-reduction process; pyruvate metabolic process; glucose homeostasis; malate metabolic process. (624 aa)
Hex-CPhosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis. (454 aa)
Hsp60CHeat shock protein 60C (Hsp60C) encodes one of the four Hsp60 family chaperone proteins. It is widely expressed and essential for embryonic viability and tracheal formation. It has essential roles in spermatogenesis and oogenesis, possibly through interaction with F-Actin. (576 aa)
MME1Mitochondrial magnesium exporter 1; Mediates efflux of magnesium ions from mitochondria, suggesting a role in magnesium homeostasis. (299 aa)
Trx-2Thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. (106 aa)
Hsp60DHeat shock protein 60D (Hsp60D) encodes a protein involved in caspase-mediated apoptosis and polyQ-mediated neurodegeneration; Belongs to the chaperonin (HSP60) family. (558 aa)
MenMalic enzyme (Men) encodes a dehydrogenase that catalyzes the oxidation of malate to pyruvate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with the products of Idh, Zw, and Pgd, in a small network of NADP reducing enzymes. (763 aa)
His4rHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
Mdh2Malate dehydrogenase 2 (Mdh2) encodes one of the enzymes in the tricarboxylic acid cycle in mitochondria; Belongs to the LDH/MDH superfamily. (336 aa)
CCAPCrustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. (155 aa)
Hex-t2Hexokinase type 2; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (486 aa)
TrxTThioredoxin-T; Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Its tissue specificity suggests a regulatory role in the germline. (157 aa)
Hex-APhosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis. (541 aa)
CG13473GEO12009p1; Protein-disulfide reductase activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; disulfide oxidoreductase activity; protein disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis. (139 aa)
CG10749L-malate dehydrogenase activity. It is involved in the biological process described with: carbohydrate metabolic process; malate metabolic process; tricarboxylic acid cycle. (347 aa)
CG10748L-malate dehydrogenase activity. It is involved in the biological process described with: tricarboxylic acid cycle; malate metabolic process; carbohydrate metabolic process. (349 aa)
coltCongested-like trachea protein; Putative mitochondrial carrier of unknown solute specificity. Required for gas-filling of the tracheal system at hatching time of the embryo and for normal epithelial morphogenesis of the wings. (306 aa)
Hsp60B60 kDa heat shock protein homolog 1, mitochondrial; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. (648 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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