CLIP domain-containing serine protease; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. CLIP subfamily.

Obstructor-J; Chitin binding. It is involved in the biological process described with: chitin metabolic process.

Uncharacterized protein, isoform C; Carbohydrate binding.

Drosomycin-like 4 (Drsl4) encodes a secreted peptide with homology to the antifungal peptide encoded by Drs.

Uncharacterized protein, isoform C; Carbohydrate binding.

Down syndrome cell adhesion molecule 4 (Dscam4) one of four Dscam paralogs in the D. melanogaster genome. It encodes a homophilic cell adhesion molecule that regulates interactions between dendrites and axons in the visual system.

Uncharacterized protein, isoform C; Carbohydrate binding.

Obstructor-J; Chitin binding. It is involved in the biological process described with: chitin metabolic process.

Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).

Glutathione S-transferase D5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May be involved in detoxification. Belongs to the GST superfamily. Delta family.

Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).

Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis; Belongs to the nuclear hormone receptor family. NR1 subfamily.

Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).

Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress.

Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).

Segmentation protein cap'n'collar; Plays a role in posterior cephalic patterning. Probable subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis. Isoform B may have a repressive effect on Dfd response elements, thereby modifying the activity and specificity of the Hox system and moving the body anterior/posterior axis.

Cytochrome P450-4e3 (Cyp4e3) encodes an endoplasmic reticulum protein that plays a role in insecticide tolerance. Upon insecticide feeding Cyp4e3 is significantly up-regulated. Cyp4e3 knockdown in the Malpighian tubule principal cells reduces survival of insecticide-fed flies. Cyp4e3 protein may also regulate hydrogen peroxide levels in the endoplasmic reticulum and its absence triggers JAK/STAT and NF-kappaB-mediated stress responses.

Glutathione S-transferase D5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May be involved in detoxification. Belongs to the GST superfamily. Delta family.

Drosomycin-like 4 (Drsl4) encodes a secreted peptide with homology to the antifungal peptide encoded by Drs.

Uncharacterized protein, isoform C; Carbohydrate binding.

Drosomycin-like 4 (Drsl4) encodes a secreted peptide with homology to the antifungal peptide encoded by Drs.

Peptidoglycan recognition protein SC2 (PGRP-SC2) encodes a secreted peptidoglycan recognition protein (PGRP) with an amidase activity against peptidoglycans. It contributes to the down-regulation of the immune deficiency pathway, notably in the fat body during systemic bacterial infection.

Down syndrome cell adhesion molecule 4 (Dscam4) one of four Dscam paralogs in the D. melanogaster genome. It encodes a homophilic cell adhesion molecule that regulates interactions between dendrites and axons in the visual system.

Uncharacterized protein, isoform C; Carbohydrate binding.

Estrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages.

Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis.

Estrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages.

Ecdysone-induced protein 75B (Eip75B) encodes a nuclear receptor that interacts with the receptor encoded by Hr3. The product of Eip75B regulates feeding behavior, fat deposition, and developmental timing in response to nitric oxide (NO) signaling. It also acts downstream from NO in the nervous system, where it controls neuronal remodeling.

Estrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages.

Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily.

Estrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages.

Hormone receptor 3 (Hr3) encodes a protein induced directly by 20-hydroxyecdysone as a delayed-early response. It is required for tracheal air filling and ventral nerve cord condensation in embryos, for developmental progression through early metamorphosis, and in the prothoracic gland for ecdysteroid biosynthesis.

Estrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages.

Hormone receptor-like in 39 (Hr39) encodes a nuclear hormone receptor protein in subfamily 5. It is a master regulator of female reproductive gland development from the bipotential genital disc, and in adults is required for reproductive gland secretion, ovulation and additional functions.

Estrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages.

Hormone receptor 4; Coordinates growth and maturation by mediating endocrine responses to the attainment of critical weight during larval development. Plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the ftz-f1 midprepupal competence factor. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Estrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages.

Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis; Belongs to the nuclear hormone receptor family. NR1 subfamily.

Estrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages.

Segmentation protein cap'n'collar; Plays a role in posterior cephalic patterning. Probable subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis. Isoform B may have a repressive effect on Dfd response elements, thereby modifying the activity and specificity of the Hox system and moving the body anterior/posterior axis.