(22 nodes) (2021) Advances in deciphering the genetic basis of insect cuticular hydrocarbon biosynthesis and variation. network (Drosophila melanogaster)

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	Cyp4g1	Cytochrome P450-4g1 (Cyp4g1) encodes the terminal oxidative decarbonylase in cuticular hydrocarbon biosynthesis within oenocytes. (556 aa)
	FarO	Fatty acyl-CoA reductase in oenocytes (FarO) encodes a long-chain-fatty-acyl-CoA reductase involved in the regulation of cell growth and lipid storage. (504 aa)
	spidey	RH59310p; Spidey (spidey) encodes a member of the short chain dehydrogenase/reductase family. It regulates oenocyte growth and maturation, as well as the metabolism of ecdysteroids and cuticular hydrocarbons; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa)
	ecd	Ecdysoneless (ecd) encodes a protein that physically interacts with several components of the U5 snRPN pre-mRNA splicing complex. Its loss result in intron retention within spok, accounting for ecdysone deficiency of some ecd mutants; Belongs to the ECD family. (684 aa)
	Sc2	Sc2; Oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors. It is involved in the biological process described with: very long-chain fatty acid biosynthetic process. (302 aa)
	CG5599	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Acetyltransferase activity; lipoic acid binding. (462 aa)
	Fad2	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones. (355 aa)
	Hacd1	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (245 aa)
	Hacd2	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (371 aa)
	eloF	Elongation of very long chain fatty acids protein F; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis. (257 aa)
	CG9458	Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (264 aa)
	Desat2	Fatty acid desaturase 2; stearoyl-CoA 9-desaturase activity; iron ion binding. It is involved in the biological process described with: oxidation-reduction process; unsaturated fatty acid biosynthetic process; Belongs to the fatty acid desaturase type 1 family. (361 aa)
	Desat1	Desaturase 1 (Desat1) encodes a transmembrane fatty acid desaturase that utilizes myristate and stearate (C16:0 and C18:0) to synthesize myristoleic and oleic acids (C16:1 and C18:1). It is involved in the synthesis of unsaturated fatty acids. (383 aa)
	e	LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity. (879 aa)
	CG18609	Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (263 aa)
	CG30008	Elongation of very long chain fatty acids protein; Fatty acid elongase activity. (266 aa)
	FASN3	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process. (2394 aa)
	Sgp	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (523 aa)
	FASN2	Fatty acid synthase 2 (FASN2) encodes an enzyme required for the synthesis of branched/methylated long chain fatty acids that are the precursors of methylated cuticular hydrocarbons. (2410 aa)
	FASN1	Fatty acid synthase 1 (FASN1) encodes a fatty acid synthase involved in glycogen metabolism and triglyceride biosynthesis. (2540 aa)
	ND-13A	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (126 aa)
	CG10097	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (501 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG10097	CG18609	FBpp0312436	FBpp0085825	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.569
CG10097	CG30008	FBpp0312436	FBpp0087468	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.681
CG10097	CG5599	FBpp0312436	FBpp0073781	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Acetyltransferase activity; lipoic acid binding.	0.424
CG10097	CG9458	FBpp0312436	FBpp0081630	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.698
CG10097	Cyp4g1	FBpp0312436	FBpp0070094	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Cytochrome P450-4g1 (Cyp4g1) encodes the terminal oxidative decarbonylase in cuticular hydrocarbon biosynthesis within oenocytes.	0.419
CG10097	Desat1	FBpp0312436	FBpp0082096	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Desaturase 1 (Desat1) encodes a transmembrane fatty acid desaturase that utilizes myristate and stearate (C16:0 and C18:0) to synthesize myristoleic and oleic acids (C16:1 and C18:1). It is involved in the synthesis of unsaturated fatty acids.	0.605
CG10097	Desat2	FBpp0312436	FBpp0082064	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Fatty acid desaturase 2; stearoyl-CoA 9-desaturase activity; iron ion binding. It is involved in the biological process described with: oxidation-reduction process; unsaturated fatty acid biosynthetic process; Belongs to the fatty acid desaturase type 1 family.	0.534
CG10097	FASN1	FBpp0312436	FBpp0307371	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Fatty acid synthase 1 (FASN1) encodes a fatty acid synthase involved in glycogen metabolism and triglyceride biosynthesis.	0.447
CG10097	FASN2	FBpp0312436	FBpp0307370	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Fatty acid synthase 2 (FASN2) encodes an enzyme required for the synthesis of branched/methylated long chain fatty acids that are the precursors of methylated cuticular hydrocarbons.	0.641
CG10097	FASN3	FBpp0312436	FBpp0297101	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process.	0.540
CG10097	Fad2	FBpp0312436	FBpp0075926	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Fad2 (Fad2) encodes a transmembrane fatty acid desaturase that utilizes mono-unsaturated long-chain fatty acids (LCFAs) to synthesize di-unsaturated LCFAs. It is involved in the synthesis of the female pheromones.	0.497
CG10097	ND-13A	FBpp0312436	FBpp0311489	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	0.429
CG10097	eloF	FBpp0312436	FBpp0081622	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	Elongation of very long chain fatty acids protein F; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids, to yield products up to 30 carbons in length. May also elongate diunsaturated fatty acids. Important for courtship behavior where it probably has a role in female pheromone biosynthesis.	0.548
CG18609	CG10097	FBpp0085825	FBpp0312436	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.	0.569
CG18609	CG30008	FBpp0085825	FBpp0087468	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.832
CG18609	CG5599	FBpp0085825	FBpp0073781	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Acetyltransferase activity; lipoic acid binding.	0.465
CG18609	CG9458	FBpp0085825	FBpp0081630	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	0.564
CG18609	Cyp4g1	FBpp0085825	FBpp0070094	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Cytochrome P450-4g1 (Cyp4g1) encodes the terminal oxidative decarbonylase in cuticular hydrocarbon biosynthesis within oenocytes.	0.774
CG18609	Desat1	FBpp0085825	FBpp0082096	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Desaturase 1 (Desat1) encodes a transmembrane fatty acid desaturase that utilizes myristate and stearate (C16:0 and C18:0) to synthesize myristoleic and oleic acids (C16:1 and C18:1). It is involved in the synthesis of unsaturated fatty acids.	0.544
CG18609	Desat2	FBpp0085825	FBpp0082064	Elongation of very long chain fatty acids protein; Fatty acid elongase activity.	Fatty acid desaturase 2; stearoyl-CoA 9-desaturase activity; iron ion binding. It is involved in the biological process described with: oxidation-reduction process; unsaturated fatty acid biosynthetic process; Belongs to the fatty acid desaturase type 1 family.	0.430