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Gr63a Gr63a Gr5a Gr5a Ir8a Ir8a Gr61a Gr61a ACXD ACXD Gr64a Gr64a ppk28 ppk28 Ir76b Ir76b Ir64a Ir64a Gr21a Gr21a Orco Orco Gr33a Gr33a ACXC ACXC ACXB ACXB ACXA ACXA myo myo Or46a Or46a Or69a Or69a Ir75a Ir75a Gr66a Gr66a CG32301 CG32301 CG32305 CG32305 CngA CngA Ir25a Ir25a Ir84a Ir84a Gr43a Gr43a ORY ORY
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Gr63aGustatory and odorant receptor 63a; Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a. (489 aa)
Gr5aGustatory receptor 5a for trehalose; Gustatory receptor required for response to the sugar trehalose in taste neurons. Gr5a neurons selectively respond to sugars, in contrast to Gr66a cells which respond to bitter compounds. Flies are attracted to sugars and avoid bitter substances, suggesting that Gr5a neuron activity is sufficient to mediate acceptance behavior. Sugar signal transduction occurs through coupling with G-proteins such as Galpha49B and G-salpha60A. (444 aa)
Ir8aIonotropic receptor 8a (Ir8a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as a co-receptor together with ligand-specific IRs (in a probable heterotetrameric complex) to detect diverse organic acids; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (936 aa)
Gr61aGustatory receptor for sugar taste 61a; One of the few identified sugar gustatory receptors identified so far with glucose being its primary ligand and which mediates acceptance behavior. (436 aa)
ACXDAdenylyl cyclase X D, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1162 aa)
Gr64aGustatory receptor for sugar taste 64a; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily. (456 aa)
ppk28Pickpocket protein 28; Osmosensitive ion channel that mediates the cellular and behavioral response to water. Plays an essential role in gustatory water reception. Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (606 aa)
Ir76bIonotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit. (636 aa)
Ir64aIonotropic receptor 64a (Ir64a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It is part of a broad-specificity acid sensor that mediates avoidance behavior. (859 aa)
Gr21aGustatory and odorant receptor 21a; Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr [...] (447 aa)
OrcoOdorant receptor coreceptor; Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-deriv [...] (486 aa)
Gr33aGustatory and pheromone receptor 33a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing all nonvolatile repulsive chemicals, including tastants, pheromones, and especially N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions also as a pheromone receptor for a male inhibitory pheromone leading to male-male courtship suppression. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (475 aa)
ACXCAdenylyl cyclase X C, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; spermatogenesis; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1130 aa)
ACXBAdenylyl cyclase X B; Adenylate cyclase activity. It is involved in the biological process described with: spermatogenesis; cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1114 aa)
ACXAAdenylyl cyclase X A, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-activating G protein-coupled receptor signaling pathway; cyclic nucleotide biosynthetic process; spermatogenesis. (1112 aa)
myoMyoglianin, isoform A; Myoglianin (myo) encodes a protein expressed primarily in muscle and glia cells. Mutations in myo affect neuronal remodeling during metamorphosis by failing to activate EcR expression in the remodeling neurons. (598 aa)
Or46aOdorant receptor 46a, isoform B; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity); Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily. (384 aa)
Or69aPutative odorant receptor 69a, isoform A; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity); Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily. (393 aa)
Ir75aIonotropic receptor 75a; Odorant receptor for acetic and propionic acid. Functions as part of an olfactory receptor complex including the ionotropic receptor coreceptor Ir8a; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (629 aa)
Gr66aGustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...] (527 aa)
CG32301Uncharacterized protein, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-activating G protein-coupled receptor signaling pathway; chaeta development; notum development; cyclic nucleotide biosynthetic process. (1111 aa)
CG32305Uncharacterized protein; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1164 aa)
CngACyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies. (840 aa)
Ir25aIonotropic receptor 25a; Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection. Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b. Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool av [...] (947 aa)
Ir84aIonotropic receptor 84a (Ir84a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in detection of phenylacetic acid and controls male courtship behavior. (644 aa)
Gr43aGustatory receptor for sugar taste 43a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies. (453 aa)
ORYOccludin-Related Y. (914 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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