STRINGSTRING
PGRP-SB1 PGRP-SB1 Tep1 Tep1 Spn88Eb Spn88Eb TotA TotA Mtk Mtk CG4793 CG4793 CG4259 CG4259
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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co-expression
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Your Input:
PGRP-SB1Peptidoglycan recognition protein SB1 (PGRP-SB1) encodes a secreted peptidoglycan recognition protein (PGRP) with an amidase activity against DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It is strongly induced upon bacterial infection by the immune deficiency pathway, suggesting a role as an immune effector; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (190 aa)
Tep1Thioester-containing protein 1; Endopeptidase inhibitor activity. It is involved in the biological process described with: innate immune response. (1354 aa)
Spn88EbCG6687 protein; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: response to fungus; negative regulation of endopeptidase activity; epithelium regeneration; regulation of stem cell division; negative regulation of proteolysis; Belongs to the serpin family. (426 aa)
TotAProtein Turandot A; A humoral factor that plays a role in stress tolerance; gives increased resistance to the lethal effects of bacterial challenge and stress. Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway in the fat body, upd3 in the hemocytes and Mekk1 in response to septic injury and consequent immune response. Belongs to the Turandot family. (129 aa)
MtkMetchnikowin (Mtk) encodes an antifungal peptide that is secreted from the fat body during the systemic immune response, and is produced by various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency and/or Toll pathways. (52 aa)
CG4793Peptidase S1 domain-containing protein; Serine-type endopeptidase activity. It is involved in the biological process described with: positive regulation of hemocyte proliferation; proteolysis. (910 aa)
CG4259SD22430p; It is involved in the biological process described with: proteolysis. (270 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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