Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Pellino (Pli) encodes a RING-domain-containing ubiquitin E3 ligase that coordinates with ubiquitin-activating (E1) and ubiquitin-conjugating (E2) enzymes to degrade target proteins. It functions as a negative regulator of the Toll-mediated innate immunity pathway.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.

Pellino (Pli) encodes a RING-domain-containing ubiquitin E3 ligase that coordinates with ubiquitin-activating (E1) and ubiquitin-conjugating (E2) enzymes to degrade target proteins. It functions as a negative regulator of the Toll-mediated innate immunity pathway.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Pellino (Pli) encodes a RING-domain-containing ubiquitin E3 ligase that coordinates with ubiquitin-activating (E1) and ubiquitin-conjugating (E2) enzymes to degrade target proteins. It functions as a negative regulator of the Toll-mediated innate immunity pathway.

TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.

E3 ubiquitin-protein ligase Smurf1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation.

TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.

E3 ubiquitin-protein ligase Smurf1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation.

Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family.

TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.

Pellino (Pli) encodes a RING-domain-containing ubiquitin E3 ligase that coordinates with ubiquitin-activating (E1) and ubiquitin-conjugating (E2) enzymes to degrade target proteins. It functions as a negative regulator of the Toll-mediated innate immunity pathway.

TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.

E3 ubiquitin-protein ligase Smurf1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation.

Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family.

E3 ubiquitin-protein ligase Smurf1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation.

Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family.

Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination.

Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family.

Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...]

Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination.

Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family.

Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination.

Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...]

Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination.

Echinus splice form 3; Echinus (ec) encodes a protein phosphatase 1 (PP1) binding protein involved in interommatidial cell sorting and cell death.

Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...]

Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family.

Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...]

Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination.

Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...]

Echinus splice form 3; Echinus (ec) encodes a protein phosphatase 1 (PP1) binding protein involved in interommatidial cell sorting and cell death.

Echinus splice form 3; Echinus (ec) encodes a protein phosphatase 1 (PP1) binding protein involved in interommatidial cell sorting and cell death.

Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination.

Echinus splice form 3; Echinus (ec) encodes a protein phosphatase 1 (PP1) binding protein involved in interommatidial cell sorting and cell death.

Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...]