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Adh Adh Syn Syn Vmat Vmat Syngr Syngr VGAT VGAT betaTub56D betaTub56D Rab7 Rab7 VAChT VAChT Syt1 Syt1 ORY ORY Csp Csp VGlut VGlut Syb Syb
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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AdhAlcohol dehydrogenase (Adh) encodes an alcohol and acetaldehyde dehydrogenase involved in alcohol and acetaldehyde metabolism. (256 aa)
SynSynapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. (1041 aa)
VmatVesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles. (646 aa)
SyngrSynaptogyrin (Syngr) encodes a synaptic vesicle protein implicated in vesicle endocytosis during the bulk endocytosis process. It is the sole Drosopohila homolog of the synaptophysin/synaptogryin synaptic vesicle family of proteins. (241 aa)
VGATVesicular GABA Transporter (VGAT) encodes an essential transporter that is responsible for packaging the neurotransmitter GABA into synaptic vesicles. (549 aa)
betaTub56DTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
Rab7Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. (207 aa)
VAChTVesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family. (578 aa)
Syt1Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. (474 aa)
ORYOccludin-Related Y. (914 aa)
CspDnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. (249 aa)
VGlutVesicular glutamate transporter, isoform A. (632 aa)
SybSynaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release. (152 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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