Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Insulin-like peptide 4 (Ilp4) encodes a protein involved in larval feeding behavior; Belongs to the insulin family.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination.

Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc.

Roundabout 1 (robo1) encodes a member of the Robo receptor family that uses the secreted glycoprotein encoded by sli as ligand and the products of Sdc and Dscam1 as co-receptors. It contributes to axon guidance and dendrite morphogenesis as well as regulating trachea and heart tube development.

Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc.

Roundabout 2 (robo2) encodes a member of the Robo receptor family that responds to the ligand encoded by sli as a repulsive cue in axons, dendrites, muscles, trachea and heart development. It can also inhibit robo1 signaling, likely explaining why the product of robo2 can appear to be an attractive receptor in certain contexts.

Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc.

Roundabout 3, isoform A.

Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc.

Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.

Myc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...]

Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.

Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...]

Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.

Reversed polarity (repo) encodes a homeodomain transcription factor specifically expressed in glial cells. It is is a direct target of the pan-glial fate determinant encoded by gcm and is required for acquisition of glial fate and subsequent terminal glial differentiation.

Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.

Roundabout 1 (robo1) encodes a member of the Robo receptor family that uses the secreted glycoprotein encoded by sli as ligand and the products of Sdc and Dscam1 as co-receptors. It contributes to axon guidance and dendrite morphogenesis as well as regulating trachea and heart tube development.

Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.

Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.

Insulin-like peptide 4 (Ilp4) encodes a protein involved in larval feeding behavior; Belongs to the insulin family.

Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.

Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation.

Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.

Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth.

Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.

Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination.

Insulin-like peptide 4 (Ilp4) encodes a protein involved in larval feeding behavior; Belongs to the insulin family.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]