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babo babo CG10505 CG10505 Grx1t Grx1t SERCA SERCA sesB sesB CG5506 CG5506 CG5235 CG5235 ATPsynB ATPsynB Vha68-1 Vha68-1 Syx5 Syx5 Catsup Catsup Ctr1B Ctr1B COX5A COX5A Mekk1 Mekk1 MtnC MtnC CG11878 CG11878 Ald1 Ald1 ZnT41F ZnT41F Mpcp1 Mpcp1 trpl trpl CG14757 CG14757 MTF-1 MTF-1 Ccs Ccs whd whd MtnD MtnD Ctr1A Ctr1A Grx1 Grx1 dnk dnk CG11825 CG11825 Mvl Mvl Atox1 Atox1 Fer2LCH Fer2LCH Fer1HCH Fer1HCH nrv3 nrv3 ATP7 ATP7 MtnA MtnA Sod3 Sod3 Gclc Gclc Act5C Act5C MtnE MtnE
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baboReceptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (622 aa)
CG10505Uncharacterized protein; CG10505 encodes an ABC transporter whose expression is induced by excess copper, zinc, and cadmium. It is a target of the metal-responsive transcription factor encoded by MTF-1. (1312 aa)
Grx1tGlutaredoxin 1, testis-specific; Electron transfer activity; protein disulfide oxidoreductase activity; glutathione-disulfide reductase activity. It is involved in the biological process described with: cellular response to oxidative stress; cell redox homeostasis. (116 aa)
SERCACalcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. (1020 aa)
sesBADP,ATP carrier protein; Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. (312 aa)
CG5506LP12049p. (180 aa)
CG5235MOXD1 homolog 1; Copper ion binding; dopamine beta-monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. It is involved in the biological process described with: oxidation-reduction process; norepinephrine biosynthetic process; octopamine biosynthetic process; dopamine catabolic process. (698 aa)
ATPsynBATP synthase subunit b, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (243 aa)
Vha68-1V-type proton ATPase catalytic subunit A isoform 1; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (614 aa)
Syx5Syntaxin-5; Syntaxin 5 (Syx5) encodes a type II transmembrane protein in the Q-SNARE family that forms hetero tetramers required for membrane function in the early secretory pathway (ER and Golgi). It has been involved in cytokinesis during spermatogenesis. (467 aa)
CatsupProtein catecholamines up; Negatively regulates tyrosine hydroxylase activity; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (449 aa)
Ctr1BCopper transporter 1B (Ctr1B) encodes a protein that ensures copper uptake in the intestine. Ctr1B transcription is upregulated under conditions of copper depletion via the metal-responsive transcription factor encoded by MTF-1. (174 aa)
COX5ACytochrome c oxidase subunit 5A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (149 aa)
Mekk1Mekk1, isoform B; Mekk1 (Mekk1) encodes a MAP kinase kinase kinase that regulates the stress response. It is required for resistance to several stresses, notably osmotic shock, and for the regulation of the activity of the product of Duox. (1571 aa)
MtnCMetallothionein-3; Metallothionein C (MtnC) encodes a member of the Metallothionein family whose transcription is strongly inducible by copper and cadmium ions. Its induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family. (43 aa)
CG11878IP11925p. (420 aa)
Ald1Fructose-bisphosphate aldolase; May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases). (363 aa)
ZnT41FZinc ion transmembrane transporter activity. It is involved in the biological process described with: detoxification of zinc ion; regulation of sequestering of zinc ion; zinc ion transport; zinc ion transmembrane transport; response to zinc ion. (498 aa)
Mpcp1Mitochondrial phosphate carrier protein 1, isoform A; Phosphate ion transmembrane transporter activity; inorganic phosphate transmembrane transporter activity. It is involved in the biological process described with: phosphate ion transport; phosphate ion transmembrane transport; Belongs to the mitochondrial carrier (TC 2.A.29) family. (374 aa)
trplTransient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. (1124 aa)
CG14757Succinate dehydrogenase assembly factor 2-A, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. (163 aa)
MTF-1Metal response element-binding Transcription Factor-1 (MTF-1) encodes a zinc finger protein that primarily controls the homeostasis of physiological trace metals, such as zinc and copper, and the detoxification of non-essential, toxic heavy metals, such as cadmium, mercury, and silver. It activates a number of genes in response to heavy metal load but also induces transcription of the copper importer encoded by Ctr1B upon copper depletion. Variations in the DNA binding site can affect its response to a specific metal. (1006 aa)
CcsCopper chaperone for superoxide dismutase (Ccs) encodes a protein required for the proper superoxide dismutase function of the product of Sod1. It is involved in determination of lifespan, oxidative stress, and cytosolic aconitase activity. (264 aa)
whdWithered (whd) encodes a carnitine O-palmitoyltransferase involved in oxidative stress. (782 aa)
MtnDMetallothionein-4; Metallothionein D (MtnD) encodes a member of the Metallothionein family whose transcription is strongly inducible by copper and cadmium ions. Its induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family. (44 aa)
Ctr1ACopper transporter 1A (Ctr1A) encodes a plasma membrane protein that functions as a copper transporter. It is required to drive neuropeptide maturation during normal growth and development. (241 aa)
Grx1Glutaredoxin 1 (Grx1) encodes a protein involved in copper ion homeostasis. (114 aa)
dnkDeoxynucleoside kinase; Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, 2'-deoxyriboadenosine, 2'-deoxyribocytidine and 2'-deoxyriboguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated. (250 aa)
CG11825Uncharacterized protein, isoform C; It is involved in the biological process described with: mitochondrial respirasome assembly; copper ion homeostasis. (136 aa)
MvlMalvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn[2+] and Fe[2+]. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling. (639 aa)
Atox1Antioxidant 1 copper chaperone (Atox1) null mutants are unable to develop on low-copper food. Furthermore, the intestinal copper importer encoded by Ctr1B, which is regulated by copper demand, fails to be induced upon copper starvation in Atox1 mutant larvae, while intestinal metallothionein is upregulated. This suggests intestinal copper accumulation, combined with insufficient delivery to the rest of the body. (89 aa)
Fer2LCHFerritin 2 light chain homologue (Fer2LCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer2LCH provides iron nucleation sites in the internal cavity of the complex required for iron mineralization and is essential for embryogenesis. (236 aa)
Fer1HCHFerritin 1 heavy chain homologue (Fer1HCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer1HCH has ferroxidase activity required for iron loading into ferritin and is essential for embryogenesis. (245 aa)
nrv3Nervana 3 (nrv3) encodes one of three beta subunits of the sodium-potassium pump (ATPalpha). nrv3 is expressed in the nervous system, including subsets of the CNS and Johnston's organ neurons, and is required for hearing. (313 aa)
ATP7ATP7, isoform B; ATP7 (ATP7) encodes a copper transmembrane transporter involved in cuticle pigmentation, copper homeostasis and larval development. (1254 aa)
MtnAMetallothionein-1; Metallothionein A (MtnA) encodes a member of the Metallothionein family whose transcript level is higher than that of the other four Drosophila metallothioneins. Transcription is strongly induced by copper and cadmium ions and this induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family. (40 aa)
Sod3Superoxide dismutase 3 (Sod3) encodes an extra-cellular Cu Zn superoxide dismutase that can be produced as secreted and membrane bound forms. It converts oxygen free radicals to hydrogen peroxide and is involved in free radical defense and redox balance; Belongs to the Cu-Zn superoxide dismutase family. (243 aa)
GclcGlutamate-cysteine ligase catalytic subunit (Gclc) encodes a heterodimeric enzyme involved in the first rate-limiting step of glutathione synthesis. It binds L-cysteine and L-glutamate to form gamma-glutamylcysteine; Belongs to the glutamate--cysteine ligase type 3 family. (717 aa)
Act5CActin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
MtnEMetallothionein E (MtnE) encodes one of the five metallothioneins. They are metal-binding polypeptides that coordinate both physiological and xenobiotic metal ions, either for homeostasis or detoxification purposes. The product of MtnE shows the least specificity towards binding metal ions. (41 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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