STRINGSTRING
SP SP Or67d Or67d ppk ppk Or88a Or88a ppk25 ppk25 Or47b Or47b Mat1 Mat1 unpg unpg fru fru
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Your Input:
SPAccessory gland-specific peptide 70A; Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila. Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors. Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial pe [...] (55 aa)
Or67dOdorant receptor 67d; Plays a role in detection and sensitivity to pheromones and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Necessary to mediate behavioral responses to cVA by regulating both male and female mating behavior. Activation of Or67d neurons by cVA inhibits courtship of other males, whereas in females their activation promotes receptivity to othe [...] (391 aa)
ppkAmiloride-sensitive Na+ channel; Pickpocket (ppk) encodes an acid-sensing sodium channel from the degenerin/epithelial sodium channel (DEG/ENaC) family. It contributes to mechanical nociception, larval behavior and dendrite morphogenesis. (606 aa)
Or88aOdorant receptor 88a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (401 aa)
ppk25Pickpocket 25 (ppk25) encodes a DEG/ENaC channel subunit involved in male courtship behavior and pheromone detection; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (451 aa)
Or47bOdorant receptor 47b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Plays an important role in sociosexual interactions since its enhances courtship in a pheromone- dependent manner. (412 aa)
Mat1CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. (320 aa)
unpgHomeobox protein unplugged; Plays a regulatory role in neural branching of the tracheae: segment-specific aspects of these neural branching patterns appear to be generated by homeotic regulation of expression. May have a role with oc/otd in the postembryonic development of the brain. (485 aa)
fruSex determination protein fruitless; Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associ [...] (960 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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