STRINGSTRING
ph-p ph-p DnaJ-1 DnaJ-1 crq crq CG12163 CG12163 Col4a1 Col4a1 He He NimB2 NimB2 Tep1 Tep1 Ars2 Ars2 Cp1 Cp1 PPO2 PPO2 Pxn Pxn Mlf Mlf peb peb mt:ND2 mt:ND2 Mmp1 Mmp1 Rpn3 Rpn3 PPO1 PPO1 klu klu CG11459 CG11459 imd imd
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ph-pPolyhomeotic-proximal chromatin protein; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Plays a [...] (1589 aa)
DnaJ-1DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. (334 aa)
crqCroquemort (crq) encodes a member of the scavenger receptor class B sub-family. It is expressed in plasmatocyte/macrophages and promotes apoptotic cell clearance. In epidermal cells it plays a role in phagosome maturation in both dendrite pruning and injury. (491 aa)
CG12163Putative cysteine proteinase CG12163; May have a role in autophagic cell death. Belongs to the peptidase C1 family. (614 aa)
Col4a1Collagen alpha-1(IV) chain; Collagen type IV alpha 1 (Col4a1) encodes a subunit of Collagen IV and a major component of basement membranes. It is required for muscle and epithelium integrity. (1779 aa)
HeHemocyte-specific protein HEMESE; It is involved in the biological process described with: encapsulation of foreign target; negative regulation of lamellocyte differentiation; innate immune response. (156 aa)
NimB2Nimrod B2; It is involved in the biological process described with: defense response to bacterium; mesoderm development. (421 aa)
Tep1Thioester-containing protein 1; Endopeptidase inhibitor activity. It is involved in the biological process described with: innate immune response. (1354 aa)
Ars2Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha; Belongs to the ARS2 family. (943 aa)
Cp1Cathepsin L heavy chain; Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion; Belongs to the peptidase C1 family. (371 aa)
PPO2Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. (684 aa)
PxnPeroxidasin; Plays a role in extracellular matrix consolidation, phagocytosis and defense. (1527 aa)
MlfMyeloid leukemia factor; Transcription factor binding; chaperone binding. It is involved in the biological process described with: regulation of cell proliferation involved in compound eye morphogenesis; protein stabilization; regulation of transcription, DNA-templated; positive regulation of crystal cell differentiation. (376 aa)
pebPebbled, isoform A; Pebbled (peb) encodes a protein that acts as a tissue-specific transcriptional attenuator. It contributes to embryonic morphogenesis and development of ovary, retina and respiratory system. (1894 aa)
mt:ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (341 aa)
Mmp1Matrix metalloproteinase 1 (Mmp1) encodes a proteinase that cleaves proteins in the extracellular matrix. It is involved in tissue histolysis and remodeling during metamorphosis, tracheal remodeling, wound healing, wing regeneration, neoplastic growth, and circadian behavior. It has been used as a reporter for JNK signaling since it is upregulated by the pathway. (584 aa)
Rpn3Probable 26S proteasome non-ATPase regulatory subunit 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (494 aa)
PPO1Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. (690 aa)
kluKlumpfuss, isoform B; Cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding. (818 aa)
CG11459GH15170p; Cysteine-type endopeptidase activity. It is involved in the biological process described with: proteolysis involved in cellular protein catabolic process; Belongs to the peptidase C1 family. (336 aa)
imdProtein immune deficiency; Essential for the imd/NF-kappa-B (Imd) humoral and epithelial immune response to Gram-negative bacteria. Functions as an adapter protein that transduces immunity signals from the activation of pathogen recognition receptors (PRRs) by bacterial infection to the Imd signaling pathway. Binding of diaminopimelic acid-type (DAP-type) bacterial peptidoglycans (PGN) causes multimerization or clustering of PGRP receptors which activate the Imd cascade probably by recruiting imd, Fadd and Dredd to the receptor complex. Once in proximity, Dredd cleaves imd in a Fadd-de [...] (273 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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