node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Decay | Parp | FBpp0082755 | FBpp0112608 | Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. | 0.992 |
Decay | Psn | FBpp0082755 | FBpp0077850 | Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family. | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | 0.688 |
Nct | Psn | FBpp0306637 | FBpp0077850 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | 0.999 |
Nct | pen-2 | FBpp0306637 | FBpp0309291 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. | 0.999 |
Parp | Decay | FBpp0112608 | FBpp0082755 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. | Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family. | 0.992 |
Psn | Decay | FBpp0077850 | FBpp0082755 | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family. | 0.688 |
Psn | Nct | FBpp0077850 | FBpp0306637 | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | 0.999 |
Psn | Ubqn | FBpp0077850 | FBpp0309477 | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | Ubiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. | 0.875 |
Psn | pen-2 | FBpp0077850 | FBpp0309291 | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. | 0.999 |
Ubqn | Psn | FBpp0309477 | FBpp0077850 | Ubiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | 0.875 |
Ubqn | ubl | FBpp0309477 | FBpp0085529 | Ubiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. | Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. | 0.845 |
pen-2 | Nct | FBpp0309291 | FBpp0306637 | Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | 0.999 |
pen-2 | Psn | FBpp0309291 | FBpp0077850 | Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | 0.999 |
ubl | Ubqn | FBpp0085529 | FBpp0309477 | Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. | Ubiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. | 0.845 |