STRINGSTRING
SH3PX1 SH3PX1 Tsp2A Tsp2A Vps26 Vps26 Syx4 Syx4 Rala Rala dx dx Moe Moe shg shg Egfr Egfr Vps35 Vps35 Pi3K59F Pi3K59F Eps-15 Eps-15 stet stet sl sl Shc Shc Cbl Cbl Rab5 Rab5 Su(dx) Su(dx) Vps29 Vps29 Syx7 Syx7 wg wg Stam Stam Art8 Art8 Sos Sos aurA aurA Lkb1 Lkb1 Akt1 Akt1 Rab11 Rab11 InR InR Syx18 Syx18 Exo84 Exo84 spdo spdo Gprk2 Gprk2 krz krz ubl ubl Rab4 Rab4 Rho1 Rho1 drk drk egr egr Hrs Hrs Chc Chc DopEcR DopEcR hh hh baz baz Nedd4 Nedd4 Atg1 Atg1 Tao Tao smog smog pyd pyd aPKC aPKC Syx17 Syx17 Vang Vang zfh1 zfh1 rho rho Rab35 Rab35 Diap1 Diap1 shi shi Tor Tor RtGEF RtGEF numb numb Vap33 Vap33 Vps4 Vps4 Fas2 Fas2 ras ras
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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SH3PX1Sorting nexin; Phosphatidylinositol-4,5-bisphosphate binding; kinase binding; protein binding; Belongs to the sorting nexin family. (565 aa)
Tsp2ATetraspanin-2A; Required for assembly of smooth septate junctions (sSJs), together with Ssk and mesh. Important for barrier function of the midgut epithelium; Belongs to the tetraspanin (TM4SF) family. (244 aa)
Vps26Vacuolar protein sorting-associated protein 26; Component of the retromer complex which acts in conjunction with wingless (wg) and clathrin-mediated endocytosis to sustain a wntless (wls) traffic loop. This loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, thereby enabling wls to direct wg secretion. The hh and dpp signaling pathways do not require the retromer complex suggesting that it does not play a general role in exocytosis. Belongs to the VPS26 family. (478 aa)
Syx4Syntaxin-4; Syntaxin 4 (Syx4) encodes a member of the superfamily of SNARE genes, which mediate membrane fusion. The product of Syx4 is associated with Golgi to plasma membrane transport as well as acting as a plasma membrane t-SNARE to regulate synaptic growth at the neuromuscular junction. (333 aa)
RalaRas-related protein Ral-a; Ras-like protein A (Rala) encodes a GTPase that regulates Notch, Jak/Stat and JNK signalling pathways. (201 aa)
dxProtein deltex; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway. Belongs to the Deltex family. (738 aa)
MoeMoesin/ezrin/radixin homolog 1; Involved in connections of major cytoskeletal structures to the plasma membrane. Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr. In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles. (649 aa)
shgDE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...] (1507 aa)
EgfrEpidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] (1426 aa)
Vps35Vacuolar protein sorting 35 (Vps35) encodes a component of the retromer complex that acts to recycle membrane proteins to the Golgi or plasma membrane from endocytosed vesicles. (822 aa)
Pi3K59FPhosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. (949 aa)
Eps-15Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. (1253 aa)
stetStem cell tumor, isoform B; Stem cell tumor (stet) encodes a gonad-specific intra-membrane protease of the rhomboid family that activates ligands of the product of Egfr; Belongs to the peptidase S54 family. (485 aa)
sl1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Small wing (sl) encodes a phosphatidylinositol-specific phospholiase type C that is required as a general modulator for growth downstream of the insulin pathway, and interacts with the Ras-MAPK pathway. (1236 aa)
ShcSHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development. (409 aa)
CblCbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. (878 aa)
Rab5Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. (219 aa)
Su(dx)E3 ubiquitin-protein ligase Su(dx); E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation. (949 aa)
Vps29Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (182 aa)
Syx7Syntaxin 7 (Syx7) encodes a SNARE protein that is part of the core machinery (including the products of Rab5, Rbsn-5, and Vps45) by which endocytic cargo vesicles fuse with the early endosome. (282 aa)
wgProtein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] (468 aa)
StamSignal transducing adaptor molecule (Stam) encodes a component of the ESCRT-0 complex, which mediates multivesicular body formation. It is involved in RTK signaling regulation, tracheal cell migration and endosomal trafficking. (689 aa)
Art8Arginine methyltransferase 8 (Art8) encodes a histone methyltransferase involved in methylation of both histone H3-R2 and arginine. (341 aa)
SosProtein son of sevenless; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development. (1596 aa)
aurAAurora A (aurA) encodes a protein kinase required for proper neuroblast self-renewal by regulating assymmetric protein localization. It contributes to spindle orientation, centrosome separation and pole cell formation. (411 aa)
Lkb1Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. (567 aa)
Akt1RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa)
Rab11Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. (214 aa)
InRInsulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa)
Syx18Syntaxin 18 (Syx18) encodes a SNAP receptor involved in neuromuscular synaptic transmission. (395 aa)
Exo84Exocyst 84, isoform B; Exocyst 84 (Exo84) encodes an exocyst component involved in epithelial polarity. It mediates the apical localization of the transmembrane protein encoded by crb. (672 aa)
spdoFI04474p; Sanpodo (spdo) encodes a four-pass transmembrane domain containing protein that interacts with both the product of numb and the Notch signaling pathway to enable precursor cells to divide asymmetrically to produce daughter cells of distinct fates. Its roles include cell fate specification in the nervous system, mesoderm, and endoderm. (565 aa)
Gprk2G protein-coupled receptor kinase 2 (Gprk2) encodes a member of a family of serine/threonine kinases that modulate G-protein coupled receptors. It is required for female fertility, normal egg shape, and normal egg cAMP levels. It is also implicated in Hedgehog signaling and olfactory rhythmicity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (714 aa)
krzKurtz, isoform A; Kurtz (krz) encodes a beta-arrestin (non-visual arrestin) involved in the desensitization and endocytic internalization of G protein coupled receptors, thus downregulating their activity. It also controls other signaling pathways, including Notch, receptor tyrosine kinase, Hedgehog, and Toll. It is required maternally for normal embryonic patterning and zygotically for larval viability. (470 aa)
ublUbiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. (73 aa)
Rab4Rab4, isoform A; Rab4 (Rab4) encodes a member of the Rab family, which are small Ras-like GTPases involved in vesicle trafficking. The product of Rab4 controls endocytic recycling and regulates synapse organization and neurotransmission in the nervous system. It also contributes to the sorting of cell adhesion molecules during epithelial morphogenesis and immune-mediators during the innate immune response. (213 aa)
Rho1Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] (192 aa)
drkProtein enhancer of sevenless 2B; Downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory). (211 aa)
egrProtein eiger, membrane form; Cytokine which acts as a ligand for wgn. Also acts as a ligand for grnd. Induces apoptosis by triggering JNK signaling. Required for JNK-dependent non-autonomous apoptosis through release from apoptotic cells and activation of apoptosis in neighboring cells. Required for JNK-independent damage-induced apoptosis in the embryonic central nervous system through regulation of the pro-apoptotic gene hid. Involved in the innate immune response to extracellular pathogens. Plays a role in the melanization immune response through its involvement in the rupture of c [...] (415 aa)
HrsHepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (760 aa)
ChcClathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. (1678 aa)
DopEcRDopamine/Ecdysteroid receptor (DopEcR) encodes a GPCR that shows ligand-biased activation. It can be activated by dopamine to increase cyclic AMP levels and by the insect steroid ecdysone to activate the MAPKinase pathway. It is widely expressed in the nervous system and can modulate a wide variety of complex behaviors including male courtship, locomotion, the response to stressful social interactions and the regulation of appetite. (322 aa)
hhProtein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune r [...] (471 aa)
bazBazooka, isoform B; Bazooka (baz) encodes a scaffold protein that forms a complex with the products of par-6 and aPKC and with other cortical, cytoskeletal and regulatory proteins. It functions in cell polarization pathways in epithelial, neuronal and other cell types. (1520 aa)
Nedd4E3 ubiquitin-protein ligase Nedd-4; Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down- regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation. (1007 aa)
Atg1Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa)
TaoSerine/threonine-protein kinase Tao; Serine/threonine-protein kinase which regulates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein. In imaginal cells, pho [...] (1039 aa)
smogSmog, isoform D; Smog (smog) encodes a G-protein-coupled receptor with a key role in gastrulation. It contributes to cell intercalation and apical constriction via myosin II activation. (951 aa)
pydPolychaetoid, isoform O; Polychaetoid (pyd) encodes a broadly acting protein that is associated with multiple proteins at the surface and within the cytoskeleton, connecting events between the two; Belongs to the MAGUK family. (2395 aa)
aPKCAtypical protein kinase C; Serine/threonine protein kinase which is required for apico- basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishmen [...] (958 aa)
Syx17Syntaxin 17, isoform B; Syntaxin 17 (Syx17) encodes a Qa type SNARE protein localizing to ER, mitochondria and autophagosomes. It mediates the fusion of autophagosomes with endosomes and lysosomes by forming a SNARE complex with the products of Snap29 and Vamp7. The product of Syx17 roles include autophagosome clearance and neuromuscular function. (346 aa)
VangVang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. (608 aa)
zfh1Zinc finger protein 1; Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. (1206 aa)
rhoProtein rhomboid; Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. Belongs to the peptidase S54 family. (355 aa)
Rab35Rab35, isoform A; Rab35 (Rab35) encodes a protein that regulates proximal versus distal growth of seamless tubes in the terminal cells of the tracheal system. (201 aa)
Diap1Death-associated inhibitor of apoptosis 1; Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8- E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid- dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppre [...] (438 aa)
shiDynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (896 aa)
TorSerine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] (2471 aa)
RtGEFRho-type guanine nucleotide exchange factor (RtGEF) encodes a putative Rho-type guanine nucleotide exchange factor for the GTPases encoded by Rac1 and Cdc42. It signals through the sterile-20 kinases encoded by Pak and hpo. The product of RtGEF contributes to regulation of postsynaptic structure, post synaptic muscle development, protein localization and the growth of epithelial tissue. (1310 aa)
numbNumb (numb) encodes a membrane-associated inhibitor of Notch signaling. It controls neuroblast and sense organ precursor asymmetric division. It is asymmetrically localized during mitosis and segregates exclusively to one of two daughter cells. (556 aa)
Vap33VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. (269 aa)
Vps4Vacuolar protein sorting 4 (Vps4) encodes an AAA family ATPase. It catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes. It functions in endosomal sorting of cargo into the multivesicular body for lysosomal degradation, abscission during cell division, virus release and nuclear envelope membrane sealing after cell division. (442 aa)
Fas2Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles. (885 aa)
rasInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (590 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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