STRINGSTRING
COX7C COX7C ND-MLRQ ND-MLRQ COX8 COX8 Act5C Act5C cype cype COX4 COX4 Sp1 Sp1 Acox57D-d Acox57D-d gom gom levy levy ND-30 ND-30 COX6B COX6B Aldh7A1 Aldh7A1 CG7630 CG7630 UQCR-C2 UQCR-C2 ATPsynbetaL ATPsynbetaL Hsp60B Hsp60B Hsp60C Hsp60C COX5B COX5B Cyt-c-d Cyt-c-d Cyt-c-p Cyt-c-p COX5A COX5A RpL32 RpL32 COX4L COX4L SdhA SdhA wal wal mt:CoI mt:CoI CG34172 CG34172 mt:CoII mt:CoII COX7A COX7A
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
COX7CCytochrome c oxidase subunit 7C (COX7C) encodes a negative regulator of neuroblast proliferation. (66 aa)
ND-MLRQNADH dehydrogenase (Ubiquinone) MLRQ subunit, isoform A; Cytochrome-c oxidase activity; NADH dehydrogenase activity. It is involved in the biological process described with: mitochondrial electron transport, NADH to ubiquinone. (83 aa)
COX8Cytochrome-c oxidase activity. (68 aa)
Act5CActin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
cypeCyclope (cype) encodes a cytochrome c oxidase subunit VIc homolog acting as an enhancer of dpp pathway phenotypes. It is involved in hair and cell growth and in ommatidia development. (77 aa)
COX4Cytochrome c oxidase subunit 4 (COX4) encodes a subunit of the cytochrome-c oxidase. It is involved in cell proliferation and golgi structural organisation. (182 aa)
Sp1Sp1, isoform F; Sp1 (Sp1) encodes a member of the Sp-family of Cys2His2-type zinc finger transcription factors. It is involved in ventral thoracic appendage specification, leg growth and in the development of type-II neuroblasts. (726 aa)
Acox57D-dAcyl-coenzyme A oxidase; FAD binding; fatty acid binding; acyl-CoA oxidase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
gomAT01821p; Gomdanji (gom) encodes a calcium ion binding protein involved in calcium-mediated signaling, courtship behavior and learning. (305 aa)
levyLevy, isoform A; Cytochrome-c oxidase activity; enzyme regulator activity. It is involved in the biological process described with: mitochondrial electron transport, cytochrome c to oxygen; determination of adult lifespan; regulation of catalytic activity; aerobic respiration. (109 aa)
ND-30NADH dehydrogenase activity; NADH dehydrogenase (ubiquinone) activity. It is involved in the biological process described with: oxidation-reduction process; reactive oxygen species metabolic process; Belongs to the complex I 30 kDa subunit family. (265 aa)
COX6BCytochrome c oxidase subunit; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. (96 aa)
Aldh7A1Aldehyde dehydrogenase 7 family member A1; Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. It is involved in the biological process described with: oxidation-reduction process. (540 aa)
CG7630RH19679p. (90 aa)
UQCR-C2Endopeptidase activity; metal ion binding; ubiquinol-cytochrome-c reductase activity. It is involved in the biological process described with: mitochondrial electron transport, ubiquinol to cytochrome c; protein processing involved in protein targeting to mitochondrion. (440 aa)
ATPsynbetaLATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (622 aa)
Hsp60B60 kDa heat shock protein homolog 1, mitochondrial; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. (648 aa)
Hsp60CHeat shock protein 60C (Hsp60C) encodes one of the four Hsp60 family chaperone proteins. It is widely expressed and essential for embryonic viability and tracheal formation. It has essential roles in spermatogenesis and oogenesis, possibly through interaction with F-Actin. (576 aa)
COX5BCytochrome-c oxidase activity. It is involved in the biological process described with: mitochondrial electron transport, cytochrome c to oxygen; mitochondrial ATP synthesis coupled proton transport. (120 aa)
Cyt-c-dCytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Cyt-c-pCytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (108 aa)
COX5ACytochrome c oxidase subunit 5A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (149 aa)
RpL3260S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
COX4LCytochrome-c oxidase activity. It is involved in the biological process described with: mitochondrial electron transport, cytochrome c to oxygen. (176 aa)
SdhASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders. (661 aa)
walWalrus, isoform A; Walrus (wal) encodes a protein involved in the development of Malpighian tubules, gut and trachea. (330 aa)
mt:CoICytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (511 aa)
CG34172HDC00331; Cytochrome-c oxidase activity. It is involved in the biological process described with: mitochondrial respirasome assembly; regulation of oxidative phosphorylation. (62 aa)
mt:CoIICytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (228 aa)
COX7ACytochrome c oxidase subunit 7A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (98 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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