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Sox100B Sox100B CG11951 CG11951 CG31233 CG31233 CG42335 CG42335 EbpIII EbpIII CG31445 CG31445 Tl Tl dsx dsx Bsg25D Bsg25D fru fru CG8773 CG8773 CG3502 CG3502 loopin-1 loopin-1 CG40470 CG40470 Myb Myb gro gro Wnt4 Wnt4 Wnt2 Wnt2 14-3-3zeta 14-3-3zeta fl(2)d fl(2)d S-Lap5 S-Lap5 S-Lap8 S-Lap8 betaTub56D betaTub56D CG2111 CG2111 CG9806 CG9806 tra tra CG6071 CG6071 S-Lap4 S-Lap4 S-Lap1 S-Lap1 S-Lap2 S-Lap2 piwi piwi betaTub85D betaTub85D Rbp1 Rbp1 CG8774 CG8774 CG5849 CG5849 CG31343 CG31343 CG31198 CG31198 superdeath superdeath SP1029 SP1029
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Sox100BSox100B (Sox100B) encodes a group E Sox domain transcription factor. It has a role in the development of somatic components of the testis during metamorphosis, where it regulates pigment cell specification. Sox100B shows sexually dimorphic expression in the embryonic gonad. (529 aa)
CG11951Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (924 aa)
CG31233Metalloaminopeptidase activity; zinc ion binding; peptide binding. It is involved in the biological process described with: peptide catabolic process; proteolysis. (952 aa)
CG42335Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (924 aa)
EbpIIIEjaculatory bulb-specific protein 3; Protein component of the posterior mating plug. (126 aa)
CG31445Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (927 aa)
TlProtein toll; Receptor for the cleaved activated form of spz, spaetzle C- 106. Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin. Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo. Promotes heterophilic cellular adhesion. Involved in synaptic targeting of motoneurons RP5 and V to muscle 12 (M12); functions as a repulsive cue inhibiting motoneuron synapse formation on muscle 13 (M13) to guide RP5 and V to the neighboring M12, where its expression is repressed by [...] (1117 aa)
dsxProtein doublesex; Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female- specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body. (572 aa)
Bsg25DBlastoderm-specific gene 25D (Bsg25D) encodes the ortholog of Ninein, a microtubule-anchoring protein in humans. Bsg25D is highly expressed at blastoderm stage embryos and its product localizes to the centrosome periphery. (1118 aa)
fruSex determination protein fruitless; Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associ [...] (960 aa)
CG8773Metalloaminopeptidase activity; peptide binding; zinc ion binding. It is involved in the biological process described with: dsRNA transport; peptide catabolic process; proteolysis. (994 aa)
CG3502Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (912 aa)
loopin-1Loopin-1, isoform A; Loopin-1 (loopin-1) encodes a testis-specific protein with homology to several leucine aminopeptidases. Sequence analysis suggest that it doesn't have enzymatic activity. It accumulates inside the axoneme-associated mitochondrial derivative in mature sperms. (526 aa)
CG40470Metalloaminopeptidase activity; zinc ion binding; peptide binding. It is involved in the biological process described with: peptide catabolic process; proteolysis. (941 aa)
MybMyb protein; DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes. (657 aa)
groGroucho (gro) encodes a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. It functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of the product of gro in response to MAPK activation weakens its repressor capacity. (730 aa)
Wnt4Protein Wnt-4; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Acts downstream of homeotic complex genes in the visceral mesoderm and is required for embryonic segmentation. Also required for cell movement and FAK regulation during ovarian morphogenesis. (539 aa)
Wnt2Protein Wnt-2; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May function in gonadogenesis and limb development. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. (352 aa)
14-3-3zeta14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. (248 aa)
fl(2)dPre-mRNA-splicing regulator female-lethal(2)D; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of [...] (536 aa)
S-Lap5Sperm-Leucylaminopeptidase 5; Metalloexopeptidase activity; aminopeptidase activity; manganese ion binding. It is involved in the biological process described with: proteolysis; mesoderm development. (549 aa)
S-Lap8Sperm-Leucylaminopeptidase 8; Aminopeptidase activity; metalloexopeptidase activity; manganese ion binding. It is involved in the biological process described with: proteolysis. (534 aa)
betaTub56DTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
CG2111Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (931 aa)
CG9806Metalloaminopeptidase activity; peptide binding; zinc ion binding. It is involved in the biological process described with: multicellular organism reproduction; peptide catabolic process; proteolysis. (911 aa)
traFemale-specific protein transformer; Member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl. Activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins. Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. No known function in males. (197 aa)
CG6071Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: multicellular organism reproduction; proteolysis; peptide catabolic process. (962 aa)
S-Lap4Sperm-Leucylaminopeptidase 4; Metalloexopeptidase activity; aminopeptidase activity; manganese ion binding. It is involved in the biological process described with: proteolysis. (524 aa)
S-Lap1Sperm-Leucylaminopeptidase 1; Aminopeptidase activity; metalloexopeptidase activity; manganese ion binding. It is involved in the biological process described with: mushroom body development; proteolysis. (555 aa)
S-Lap2Sperm-Leucylaminopeptidase 2; Aminopeptidase activity; metalloexopeptidase activity; manganese ion binding. It is involved in the biological process described with: proteolysis. (552 aa)
piwiProtein piwi; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner. [...] (843 aa)
betaTub85DTubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (446 aa)
Rbp1RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. Belongs to the splicing factor SR family. (144 aa)
CG8774Metalloaminopeptidase activity; zinc ion binding; peptide binding. It is involved in the biological process described with: proteolysis; peptide catabolic process. (942 aa)
CG5849Metalloaminopeptidase activity; peptide binding; zinc ion binding. It is involved in the biological process described with: proteolysis; peptide catabolic process. (968 aa)
CG31343Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (961 aa)
CG31198Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (940 aa)
superdeathAminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (999 aa)
SP1029Metalloaminopeptidase activity; peptide binding; zinc ion binding. It is involved in the biological process described with: proteolysis; peptide catabolic process. (932 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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