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Ubi-p63E Ubi-p63E Hml Hml Rpt6 Rpt6 Uch-L5 Uch-L5 Ubi-p5E Ubi-p5E Rad23 Rad23 CG11700 CG11700 Usp14 Usp14 Rpn8 Rpn8 Rpt4 Rpt4 Rpt1 Rpt1 ubl ubl Rpt6R Rpt6R Rpt5 Rpt5 Crz Crz Ranbp9 Ranbp9
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Ubi-p63EPolyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradatio [...] (763 aa)
HmlHemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. (3843 aa)
Rpt626S proteasome regulatory subunit 8; Regulatory particle triple-A ATPase 6 (Rpt6) encodes a subunit of the proteasome, which is responsible for the ATP-dependent degradation of obsolete or damaged proteins. Rpt6 product belongs to the heterohexameric ring formed by triple-A ATPases that unfolds ubiquitinated target proteins before their degradation. (405 aa)
Uch-L5Ubiquitin carboxy-terminal hydrolase L5 (Uch-L5) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus. (324 aa)
Ubi-p5EUbiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. (534 aa)
Rad23DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. (414 aa)
CG11700Ubiquitin protein ligase binding; protein tag. It is involved in the biological process described with: determination of adult lifespan; negative regulation of reproductive process; modification-dependent protein catabolic process; protein ubiquitination. (301 aa)
Usp14Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 14 (Usp14) encodes a deubiquitinase that associates with the 19S component of the proteasome in a reversible manner. Its functions include ubiquitin chain disassemblance for mono-ubiquitin recycling, control of protein degradation by the proteasome and regulation of proteasome subtrate interactions. (475 aa)
Rpn826S proteasome non-ATPase regulatory subunit 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the peptidase M67A family. (358 aa)
Rpt4Regulatory particle triple-A ATPase 4 (Rpt4) encodes the 19S proteasomal ATPase, which is a component of the 26S proteosome complex. It localizes to the nucleolus and participates in regulating rRNA transcription. It physically interacts with the tumor suppressor encoded by BHD. (397 aa)
Rpt126S proteasome regulatory complex subunit p48B; Regulatory particle triple-A ATPase 1 (Rpt1) encodes an AAA-type ATPase protein that forms part of the heterohexameric ATPase ring of the regulatory complex of the 26S proteasome. (433 aa)
ublUbiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. (73 aa)
Rpt6RRegulatory particle triple-A ATPase 6-related; Hydrolase activity; TBP-class protein binding; ATP binding; ATPase activity. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of RNA polymerase II transcription preinitiation complex assembly; modulation of chemical synaptic transmission; Belongs to the AAA ATPase family. (399 aa)
Rpt5Regulatory particle triple-A ATPase 5 (Rpt5) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus. (428 aa)
CrzCorazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. (154 aa)
Ranbp9Ran GTPase binding. It is involved in the biological process described with: protein import into nucleus. (1018 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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