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Traf6 Traf6 Neurl4 Neurl4 Atg8b Atg8b Anp Anp ringer ringer Nedd8 Nedd8 Atg10 Atg10 HUWE1 HUWE1 usp usp Ppa Ppa CG33981 CG33981 Chd1 Chd1 Usp1 Usp1 Nedd4 Nedd4 ana ana Atg12 Atg12 Pli Pli TER94 TER94 Ufm1 Ufm1 SkpA SkpA otu otu Cul1 Cul1 Uba1 Uba1 Fbl6 Fbl6 Atg7 Atg7 EloC EloC PCNA PCNA CG15237 CG15237 ttk ttk CG5003 CG5003 Gp93 Gp93 Cdc16 Cdc16 EloB EloB CG14891 CG14891 Akt1 Akt1 Fbxl7 Fbxl7 pic pic Aos1 Aos1 Fancl Fancl MAGE MAGE Cdc23 Cdc23 PCNA2 PCNA2 CG15141 CG15141 fzy fzy CG9934 CG9934 STUB1 STUB1 CG11070 CG11070 eIF3h eIF3h Skp2 Skp2 Mkrn1 Mkrn1 BNIP3 BNIP3 Traf4 Traf4 Cbl Cbl Uch-L5 Uch-L5 CG32085 CG32085 Fbxl4 Fbxl4 Usp7 Usp7 Uba5 Uba5 ida ida Usp5 Usp5 Pi3K59F Pi3K59F Atg8a Atg8a fh fh
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Traf6TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr. (475 aa)
Neurl4Ubiquitin protein ligase activity. (1780 aa)
Atg8bAutophagy-related 8b, isoform A; Microtubule binding; protein tag; ubiquitin protein ligase binding; GABA receptor binding. It is involved in the biological process described with: macroautophagy; autophagosome maturation; cellular response to nitrogen starvation; autophagy of mitochondrion; autophagosome assembly. (120 aa)
AnpAndropin (Anp) encodes an antibacterial peptide expressed in the male genital tract; Belongs to the andropin family. (57 aa)
ringerTubulin polymerization-promoting protein homolog; Regulator of microtubule required for axonal extension during embryonic development. Promotes microtubule bundling and polymerization. Together with futsch, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules ; Belongs to the TPPP family. (192 aa)
Nedd8NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. (84 aa)
Atg10Autophagy-related 10, isoform B; Atg12 transferase activity; Atg12 conjugating enzyme activity. It is involved in the biological process described with: cellular protein modification process; macroautophagy. (172 aa)
HUWE1Uncharacterized protein, isoform H; Ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent protein catabolic process; protein polyubiquitination; dsRNA transport. (5151 aa)
uspProtein ultraspiracle; Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post- embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene; Belongs to the nuclear hormone receptor family. NR2 subfamily. (508 aa)
PpaPartner of paired, isoform B; Partner of paired (Ppa) encodes a protein involved in response to oxidative stress. (562 aa)
CG33981Uncharacterized protein, isoform C; It is involved in the biological process described with: protein K11-linked ubiquitination. (112 aa)
Chd1Chromodomain-helicase-DNA-binding protein 1; ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome (By similarity). Involv [...] (1900 aa)
Usp1Cysteine-type endopeptidase activity; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination; Belongs to the peptidase C19 family. (1078 aa)
Nedd4E3 ubiquitin-protein ligase Nedd-4; Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down- regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation. (1007 aa)
anaAnachronism (ana) encodes a secreted glycoprotein that is expressed in glia and at lower levels in neuroblasts. It suppresses neuroblast proliferation. (477 aa)
Atg12Autophagy protein 12-like; Required for autophagy. (111 aa)
PliPellino (Pli) encodes a RING-domain-containing ubiquitin E3 ligase that coordinates with ubiquitin-activating (E1) and ubiquitin-conjugating (E2) enzymes to degrade target proteins. It functions as a negative regulator of the Toll-mediated innate immunity pathway. (424 aa)
TER94Transitional endoplasmic reticulum ATPase TER94; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in the ubiquitin-proteasome system. Important for oskar mRNA localization and/ [...] (826 aa)
Ufm1Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine- linked polymer (By similarity). The so-called ufmylation, requires the UFM1-activating E1 enzyme Uba5, the UFM1-conjugating E2 enzyme Ufc1, and the UFM1-ligase E3 enzyme Ufl1 (By similarity). This post- translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes (By similarity). The Ufm1 cascade might play a role in the development of the neuromuscular junctions. (87 aa)
SkpASKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication. (162 aa)
otuProtein ovarian tumor locus; Essential for female fertility; germ cell division and differentiation. (853 aa)
Cul1Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larv [...] (774 aa)
Uba1Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. (1191 aa)
Fbl6F-box and leucine-rich repeat protein 6, isoform A; SAM domain binding. It is involved in the biological process described with: positive regulation of ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of protein stability; ubiquitin-dependent protein catabolic process. (720 aa)
Atg7Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. (684 aa)
EloCElongin C (EloC) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. (117 aa)
PCNAProliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. (260 aa)
CG15237GEO10730p1; It is involved in the biological process described with: regulation of mitotic cell cycle spindle assembly checkpoint. (118 aa)
ttkProtein tramtrack, alpha isoform; Binds to a number of sites in the transcriptional regulatory region of ftz. Isoform alpha is required to repress genes that promote the R7 cell fate. Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en. May bind to the region 5'-AGGG[CT]GG-3'. Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk. (813 aa)
CG5003FI05230p; It is involved in the biological process described with: regulation of cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; G2/M transition of mitotic cell cycle. (713 aa)
Gp93Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. (787 aa)
Cdc16Cell division cycle 16 (Cdc16) encodes an essential subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding. (718 aa)
EloBElongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto. (118 aa)
CG14891GH16156p; Nucleic acid binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (495 aa)
Akt1RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa)
Fbxl7F-box and leucine-rich repeat protein 7 (Fbxl7) encodes a ubiquitin ligase that regulates Hippo signaling. (772 aa)
picPiccolo (pic) encodes the Ddb1 protein, which functions to recruit substrate receptors to Cul4-based E3 ubiquitin ligase complexes, which catalyze the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome. (1140 aa)
Aos1Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. (337 aa)
FanclFancl, isoform A; Fancl (Fancl) encodes a member of the Fanconi anemia pathway, which is a key mediator of DNA damage repair through homologous recombination. When mono-ubiquinated by the Fanconi core complex, it associates with the product of Fancd2 and localizes to sites of DNA damage. (381 aa)
MAGERE25453p; MAGE (MAGE) encodes a component of the SMC5/6 protein complex. This complex is critical to genome stability, and is required for homologous DNA recombination-based processes. (232 aa)
Cdc23Cell division cycle 23 (Cdc23) encodes a subunit of the anaphase promoting complex/cyclosome (APC/C). Together with other subunits, it forms a functional subcomplex of the APC/C that binds to the product of shtd and is likely to be involved in activator and substrate binding. (678 aa)
PCNA2Proliferating cell nuclear antigen 2; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. May function independently of PCNA during DNA repair. (255 aa)
CG15141LD24839p; Zinc ion binding; ubiquitin protein ligase activity. (404 aa)
fzyFI02843p; Fizzy (fzy) encodes WD40 domain protein required for the full ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C) in mitosis and meiosis. The product of fzy functions to target substrates for destruction and drive metaphase and anaphase transition. (526 aa)
CG9934LD24832p; Ubiquitin-ubiquitin ligase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent ERAD pathway; protein ubiquitination. (1217 aa)
STUB1Carboxy terminus of Hsp70-interacting protein; STIP1 homology and U-box containing protein 1 (STUB1) encodes a ubiquitin protein ligase involved in insulin signaling pathway regulation and protein ubiquitination. (289 aa)
CG11070BcDNA.LD34475; Ubiquitin-ubiquitin ligase activity. It is involved in the biological process described with: ubiquitin-dependent ERAD pathway; protein polyubiquitination. (993 aa)
eIF3hEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (338 aa)
Skp2S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. (559 aa)
Mkrn1Makorin 1, isoform A; Ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination; positive regulation of insulin receptor signaling pathway; positive regulation of oogenesis. (386 aa)
BNIP3RE48077p; It is involved in the biological process described with: mitochondrial outer membrane permeabilization; regulation of programmed cell death; positive regulation of apoptotic process. (201 aa)
Traf4TNF-receptor-associated factor 4 (Traf4) encodes an adapter protein thought to bind the TNF receptor and activate downstream signaling. However, it also has TNF independent roles, especially with respect to morphogenesis. The product of Traf4 interacts with and localizes polarity and adherens junction proteins such as the products of baz and arm respectively. It is required for normal embryonic development, cell death, and cell growth. (486 aa)
CblCbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. (878 aa)
Uch-L5Ubiquitin carboxy-terminal hydrolase L5 (Uch-L5) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus. (324 aa)
CG32085FI04525p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (666 aa)
Fbxl4F box and leucine-rich-repeat gene 4; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; negative regulation of synaptic transmission, GABAergic; negative regulation of circadian sleep/wake cycle, sleep; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (669 aa)
Usp7Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. (1129 aa)
Uba5Ubiquitin-like activating enzyme 5 (Uba5) encodes a member of the E1-like ubiquitin-activating enzyme family. It activates the protein encoded by Ufm1, and acts as a key factor in the ufmylation process. It is involved in ATP binding, catalytic activity, cofactor binding, metal ion binding, nucleotide binding and oxidoreductase activity. (404 aa)
idaImaginal discs arrested (ida) encodes a ubiquitin ligase that regulates the mitotic metaphase/anaphase transition. (777 aa)
Usp5Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 5 (Usp5) encodes an essential enzyme that cleaves unanchored lysine48-linked polyubiquitin chains. It is involved in photoreceptor differentiation, neuron pathfinding and apoptosis. (827 aa)
Pi3K59FPhosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. (949 aa)
Atg8aAutophagy-related 8a (Atg8a) encodes a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a product has roles in autophagosome formation, maintaining neuromuscular function and normal lifespan. (121 aa)
fhFrataxin homolog, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the frataxin family. (190 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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