STRINGSTRING
aPKC aPKC chp chp ras ras oc oc Rh6 Rh6 mamo mamo Act5C Act5C CTPsyn CTPsyn kni kni eys eys Kr-h1 Kr-h1 Rh5 Rh5 Trpgamma Trpgamma Act79B Act79B shi shi Galphaq Galphaq Acsl Acsl rdgB rdgB Myc Myc Lztr1 Lztr1 CG43347 CG43347 eIF4A eIF4A elav elav Arr1 Arr1 Cdc42 Cdc42 RpL22 RpL22 PIP82 PIP82 Cdc5 Cdc5 sev sev CG5800 CG5800 par-6 par-6 Rip11 Rip11 CG6512 CG6512 Rh4 Rh4 CG11262 CG11262 Arr2 Arr2 dpp dpp Pph13 Pph13 eya eya wg wg ATPsynO ATPsynO Act88F Act88F ninaE ninaE Rh3 Rh3 Rab11 Rab11 CG6015 CG6015 Sar1 Sar1 RpL32 RpL32 ttk ttk didum didum CG9932 CG9932 so so Plc21C Plc21C hh hh norpA norpA EcR EcR inaD inaD
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proteins of unknown 3D structure
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aPKCAtypical protein kinase C; Serine/threonine protein kinase which is required for apico- basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishmen [...] (958 aa)
chpChaoptin; Required for photoreceptor cell morphogenesis. Mediates homophilic cellular adhesion; Belongs to the chaoptin family. (1338 aa)
rasInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (590 aa)
ocHomeotic protein ocelliless; Transcriptional regulator involved in pattern formation and cell determination in the embryonic CNS and larval imaginal disks. Also later in development to coordinate the expression of regulatory and structural genes required for photoreceptor cell fate in the ocelli. Has a dual role in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin (rh) expression: essential for establishing the expression of rh genes in the pale subset of ommatidia as well as repressing Rh6 in outer photoreceptors. Belongs to the paired homeobox family. (664 aa)
Rh6Opsin Rh6; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (362 aa)
mamoMaternal gene required for meiosis (mamo) encodes a zinc finger C2H2 transcription factor enriched in embryonic primordial germ cells. It is required for functional gamete production. (1553 aa)
Act5CActin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
CTPsynCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Isoform 1 is required for cytoophidium assembly in female germline cells. (627 aa)
kniZygotic gap protein knirps; Transcriptional repressor. Binds to multiple sites in the eve stripe 3 enhancer element. Plays an essential role in the segmentation process both by refining the expression patterns of gap genes and by establishing pair-rules stripes of gene expression. (434 aa)
eysProtein eyes shut; Essential for the formation of matrix-filled interrhabdomeral space: critical for the formation of epithelial lumina in the retina. Acts together with prominin (prom) and the cell adhesion molecule chaoptin (chp) to choreograph the partitioning of rhabdomeres into an open system. (2176 aa)
Kr-h1Kruppel homolog 1 (Kr-h1) encodes a transcriptional regulator involved in axon pathfinding, neurite and axon remodeling as well as pupal photoreceptor maturation. In all cases, the function of the product of Kr-h1 is linked to that of the 20-hydroxyecdysone hormone. (845 aa)
Rh5Rhodopsin 5 (Rh5) encodes a visual GPCR opsin that covalently binds the chromophore retinal. A photon of light stimulates the isomerization of retinal resulting in a conformational change in the product of Rh5 and signal activation. Its peak sensitivity is in the blue and it is expressed in a subclass of R8 photoreceptors; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (382 aa)
TrpgammaTransient receptor potential-gamma protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. (1188 aa)
Act79BActin, larval muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (376 aa)
shiDynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (896 aa)
GalphaqG protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. (396 aa)
AcslAcyl-CoA synthetase long-chain, isoform J; Long-chain fatty acid-CoA ligase activity; palmitoyl-CoA ligase activity. (728 aa)
rdgBRetinal degeneration B (rdgB) encodes a member of the Class IIA Phosphatidylinositol transfer protein (PITP) family. It supports multiple biochemical functions involving lipid transfer during G-protein coupled phospholipase C activation. (1297 aa)
MycMyc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...] (717 aa)
Lztr1Leucine-zipper-like transcriptional regulator 1 homolog; Inhibitor of Ras signaling. Acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complex that mediates ubiquitination of Ras (By similarity); Belongs to the LZTR1 family. (998 aa)
CG43347Uncharacterized protein, isoform C; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II. (2684 aa)
eIF4AEukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation. (403 aa)
elavProtein elav; Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism. Belongs to the RRM elav family. (483 aa)
Arr1Phosrestin-2; Regulates photoreceptor cell deactivation. Arr1 and Arr2 proteins are mediators of rhodopsin inactivation and are essential for the termination of the phototransduction cascade. (364 aa)
Cdc42Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. (191 aa)
RpL22Ribosomal protein L22 (RpL22) encodes a member of the eukaryotic ribosomal protein eL22 family. It is ubiquitously expressed, forms part of the large ribosomal subunit and is involved in protein synthesis. (299 aa)
PIP82PIP82; It is involved in the biological process described with: cellular response to light stimulus. (1195 aa)
Cdc5Cell division cycle 5, isoform A; DNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (814 aa)
sevProtein sevenless; Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell. (2554 aa)
CG5800ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. (826 aa)
par-6Par-6, isoform A; Par-6 (par-6) encodes a scaffold protein that forms a complex with the products of baz and aPKC and with other cortical, cytoskeletal and regulatory proteins. It is involved in cell polarization, actin-based protrusion formation and tracheal branching. (351 aa)
Rip11Rab11 interacting protein (Rip11) encodes a protein that belongs to Rab11 family interacting proteins (FIP family). It binds only to the GTP bound form of the product of Rab11, thus acting as its effector. It regulates Rhodopsin transport and cytokinesis. (832 aa)
CG6512SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. (826 aa)
Rh4Opsin Rh4; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (378 aa)
CG11262CitMHS domain-containing protein; It is involved in the biological process described with: transmembrane transport. (702 aa)
Arr2Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. (401 aa)
dppProtein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] (588 aa)
Pph13PvuII-PstI homology 13 (Pph13) encodes a paired-class homeodomain protein. It is critical for rhabdomeric photoreceptor differentiation, phototransduction and rhabdomere morphogenesis. (357 aa)
eyaDevelopmental protein eyes absent; Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development. Required for the survival of eye progenitor cells at a critical stage in morphogenesis. Belongs to the HAD-like hydrolase superfamily. EYA family. (766 aa)
wgProtein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] (468 aa)
ATPsynOATP synthase subunit O, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (209 aa)
Act88FActin, indirect flight muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Required for proper formation of indirect flight muscle (IFM) myofibrils; Belongs to the actin family. (376 aa)
ninaEOpsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. (373 aa)
Rh3Rhodopsin 3 (Rh3) encodes a Rhodopsin GPCR protein that responds to UV light and activates the phototransduction cascade that leads to photoreceptor depolarization. Rh3 is expressed in R7 photoreceptors in a stochastic manner: 35% of R7 photoreceptors express Rh3 while the remaining 65% express another UV-sensitive Rhodopsin encoded by Rh4. (383 aa)
Rab11Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. (214 aa)
CG6015LD21931p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (576 aa)
Sar1Secretion-associated Ras-related 1 (Sar1) encodes a small GTPase that is recruited to the endoplasmic reticulum and initiates the recruitment of the COPII subunit complex Sec23/Sec24. (193 aa)
RpL3260S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
ttkProtein tramtrack, alpha isoform; Binds to a number of sites in the transcriptional regulatory region of ftz. Isoform alpha is required to repress genes that promote the R7 cell fate. Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en. May bind to the region 5'-AGGG[CT]GG-3'. Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk. (813 aa)
didumDilute class unconventional myosin (didum) encodes a class V unconventional myosin that binds actin and hydrolyzes ATP. It functions in mRNA localization in the oocyte, spermatid individualization during spermatogenesis, transport of pigment granules in photoreceptors and mitochondrial transport in neuronal cells; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1800 aa)
CG9932Uncharacterized protein, isoform A; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of gene expression. (2171 aa)
soSine oculis (so) encodes a homeobox-containing transcription factor that functions with the product of eya as a transcriptional co-activator. It contributes to both cell and tissue fate specification, promotion of cell proliferation and suppression of apoptosis. (416 aa)
Plc21C1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1318 aa)
hhProtein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune r [...] (471 aa)
norpA1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] (1095 aa)
EcREcdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. (878 aa)
inaDInactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. (686 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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