(5 nodes) (2022) Bioactive Oligopeptides from Ginseng (Panax ginseng Meyer) Suppress Oxidative Stress-Induced Senescence in Fibroblasts via NAD(+)SIRT1PGC-1alpha Signaling Pathway. network (Drosophila melanogaster)

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Your Input:
	Sirt1	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa)
	CG15116	Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress. (193 aa)
	PHGPx	PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress. (238 aa)
	srl	Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding. (1067 aa)
	TFAM	Mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA. (284 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG15116	PHGPx	FBpp0085780	FBpp0072932	Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress.	PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress.	0.905
CG15116	Sirt1	FBpp0085780	FBpp0080015	Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress.	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.	0.713
CG15116	TFAM	FBpp0085780	FBpp0083356	Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress.	Mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA.	0.519
CG15116	srl	FBpp0085780	FBpp0078586	Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress.	Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding.	0.667
PHGPx	CG15116	FBpp0072932	FBpp0085780	PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress.	Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress.	0.905
PHGPx	Sirt1	FBpp0072932	FBpp0080015	PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress.	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.	0.712
PHGPx	TFAM	FBpp0072932	FBpp0083356	PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress.	Mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA.	0.506
PHGPx	srl	FBpp0072932	FBpp0078586	PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress.	Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding.	0.669
Sirt1	CG15116	FBpp0080015	FBpp0085780	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.	Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress.	0.713
Sirt1	PHGPx	FBpp0080015	FBpp0072932	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.	PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress.	0.712
Sirt1	TFAM	FBpp0080015	FBpp0083356	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.	Mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA.	0.928
Sirt1	srl	FBpp0080015	FBpp0078586	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.	Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding.	0.994
TFAM	CG15116	FBpp0083356	FBpp0085780	Mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA.	Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress.	0.519
TFAM	PHGPx	FBpp0083356	FBpp0072932	Mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA.	PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress.	0.506
TFAM	Sirt1	FBpp0083356	FBpp0080015	Mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA.	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.	0.928
TFAM	srl	FBpp0083356	FBpp0078586	Mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA.	Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding.	0.930
srl	CG15116	FBpp0078586	FBpp0085780	Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding.	Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress.	0.667
srl	PHGPx	FBpp0078586	FBpp0072932	Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding.	PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress.	0.669
srl	Sirt1	FBpp0078586	FBpp0080015	Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding.	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.	0.994
srl	TFAM	FBpp0078586	FBpp0083356	Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding.	Mitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA.	0.930