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Gba1a Gba1a CG12691 CG12691 CG15572 CG15572 CG14835 CG14835 Mst77F Mst77F Mst33A Mst33A ProtB ProtB tHMG1 tHMG1 Tpl94D Tpl94D His1:CG31617 His1:CG31617 His2B:CG17949 His2B:CG17949 Mtk Mtk CG30056 CG30056 CG30356 CG30356 His1:CG33801 His1:CG33801 His1:CG33807 His1:CG33807 His1:CG33834 His1:CG33834 His1:CG33855 His1:CG33855 CG34269 CG34269 ddbt ddbt tHMG2 tHMG2 Prtl99C Prtl99C ATbp ATbp CG42355 CG42355 CG31468 CG31468 CG31010 CG31010 JYalpha JYalpha Ppr-Y Ppr-Y kl-2 kl-2 PRY PRY WDY WDY CCY CCY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gba1aGlucosylceramidase; Hydrolase activity; glucosylceramidase activity; glucosyltransferase activity. (561 aa)
CG12691IP04124p. (150 aa)
CG15572AT12403p. (485 aa)
CG14835IP06814p. (152 aa)
Mst77FHistone-like protein 18C; Not known. Encoded in the intron of cAMP-dependent protein kinase regulatory chain type I. (215 aa)
Mst33AMst33A, isoform A. (359 aa)
ProtBProtamine B (ProtB) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines. (144 aa)
tHMG1Testis-enriched HMG-box-containing protein 1 (tHMG1) encodes a chromosomal protein involved in spermatogenesis. (126 aa)
Tpl94DTransition protein-like 94D (Tpl94D) encodes a HMG-box domain protein that is expressed during chromatin reorganization in spermatids. (164 aa)
His1:CG31617Histone H1; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (256 aa)
His2B:CG17949Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
MtkMetchnikowin (Mtk) encodes an antifungal peptide that is secreted from the fat body during the systemic immune response, and is produced by various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency and/or Toll pathways. (52 aa)
CG30056Uncharacterized protein. (137 aa)
CG30356Uncharacterized protein. (149 aa)
His1:CG33801Histone H1; Nucleosomal DNA binding; double-stranded DNA binding; chromatin DNA binding. (256 aa)
His1:CG33807Histone H1; Nucleosomal DNA binding; double-stranded DNA binding; chromatin DNA binding. (256 aa)
His1:CG33834Histone H1; Double-stranded DNA binding; chromatin DNA binding; nucleosomal DNA binding. (256 aa)
His1:CG33855Histone H1; Chromatin DNA binding. It is involved in the biological process described with: nucleosome assembly. (256 aa)
CG34269Uncharacterized protein. (191 aa)
ddbtDeadbeat, isoform B; It is involved in the biological process described with: telomere capping. (117 aa)
tHMG2Testis-enriched HMG-box-containing protein 2 (tHMG2) encodes a chromosomal protein involved in spermatogenesis. (134 aa)
Prtl99CProtamine-like 99C (Prtl99C) encodes a sperm chromatin-associated protein that is essential for male fertility. It acts additively together with the products of Mst77F, ProtA and ProtB to compact the paternal chromatin; Belongs to the UPF0771 family. (201 aa)
ATbpAT-rich binding protein; May be a transcription factor for genes having (A+T) stretches in their promoter and/or enhancer regions. Binds to AT rich DNA. (388 aa)
CG42355GEO11009p1; It is involved in the biological process described with: sperm chromatin condensation. (161 aa)
CG31468GEO08873p1. (80 aa)
CG31010Uncharacterized protein, isoform A. (254 aa)
JYalphaSodium/potassium-transporting ATPase subunit alpha; JYalpha (JYalpha) is a gene essential for male fertility as mutants produce immotile sperm. (1009 aa)
Ppr-YProtein phosphatase 1 regulatory subunit. (569 aa)
kl-2Male fertility factor kl2; ATP binding; ATPase activity; dynein intermediate chain binding; dynein light intermediate chain binding; ATP-dependent microtubule motor activity, minus-end-directed. It is involved in the biological process described with: cilium movement; microtubule-based movement. (4459 aa)
PRYPolycystin-related Y protein. (1247 aa)
WDYWD repeat-containing protein on Y chromosome; Histone binding. It is involved in the biological process described with: histone H3-K4 methylation. (1069 aa)
CCYCoiled-Coils Y. (1333 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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