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tyf tyf Not3 Not3 eIF4E1 eIF4E1 Not10 Not10 eIF4E7 eIF4E7 LSm1 LSm1 Dis3l2 Dis3l2 Rcd-1 Rcd-1 eIF4E3 eIF4E3 eIF4E5 eIF4E5 eIF4E4 eIF4E4 Clp Clp Wdr33 Wdr33 Sym Sym Rpb3 Rpb3 CstF64 CstF64 Cpsf73 Cpsf73 Cpsf100 Cpsf100 CstF50 CstF50 pAbp pAbp Dcr-2 Dcr-2 Cpsf160 Cpsf160 Cpsf5 Cpsf5 eIF4G1 eIF4G1 pcm pcm WRNexo WRNexo eIF4E6 eIF4E6 eIF4A eIF4A Gld2 Gld2 Cnot4 Cnot4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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tyfTwenty-four, isoform B; Twenty-four (tyf) encodes a protein that forms a complex together with the products of Atx2 and Lsm12. This complex binds per mRNA and activates its translation to sustain circadian rhythms. The tyf product is also involved in immune defense against Listeria monocytogenes infection. (1911 aa)
Not3CCR4-NOT transcription complex subunit 3 (Not3) encodes a poly(A)-specific ribonuclease involved in translation inhibition. (844 aa)
eIF4E1Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family. (259 aa)
Not10CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity). (635 aa)
eIF4E7Eukaryotic translation initiation factor 4E7 (eIF4E7) encodes a protein involved in translational initiation. (429 aa)
LSm1U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (137 aa)
Dis3l2Dis3 like 3'-5' exoribonuclease 2 (Dis3l2) encodes a 3'-5'-exoribonuclease involved in catabolism of miRNA and tRNA; Belongs to the RNR ribonuclease family. (1044 aa)
Rcd-1Required for cell differentiation 1, isoform A; It is involved in the biological process described with: negative regulation of translation; mRNA catabolic process. (304 aa)
eIF4E3Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability. (244 aa)
eIF4E5Eukaryotic translation initiation factor 4E5 (eIF4E5) encodes a protein in translational initiation. (232 aa)
eIF4E4Eukaryotic translation initiation factor 4E4 (eIF4E4) encodes a protein involved in translational initiation. (229 aa)
ClpCleavage and polyadenylation specificity factor subunit 4; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity. Binds RNA polymers with a preference for G- and/or C-rich clusters. Binds single-stranded DNA non-specifically. (296 aa)
Wdr33WD repeat domain 33, isoform A; It is involved in the biological process described with: mRNA polyadenylation. (807 aa)
SymSymplekin (Sym) encodes a large protein that contains many protein interaction sites, and acts as a scaffold for protein complexes in the nucleus. It functions in RNA 3' end formation for both polyadenyated mRNAs and non-polyadenylated histone mRNAs. In some cells it also localizes to the cell cortex, especially the tricellular junctions of some epithelia. (1165 aa)
Rpb3RNA polymerase II 33kD subunit; DNA-directed 5'-3' RNA polymerase activity; RNA polymerase II activity; protein dimerization activity; DNA binding. It is involved in the biological process described with: transcription by RNA polymerase II; cellular response to heat. (275 aa)
CstF64Cleavage stimulation factor 64 kD subunit (CstF64) encodes an RNA-binding protein that is part of the cleavage stimulation factor (CstF) complex. As part of the CstF complex, it interacts with the polyadenylation protein encoded bysu(f). The product of CstF64 is necessary for the cleavage and polyadenylation of most mRNAs and for 3' end processing of mRNAs that encode the replication-dependent histones. (419 aa)
Cpsf73Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] (684 aa)
Cpsf100Probable cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'- ends of polyadenylated and histone pre-mRNA. (756 aa)
CstF50Cleavage stimulation factor 50 kD subunit. (424 aa)
pAbpPolyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...] (634 aa)
Dcr-2Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. (1722 aa)
Cpsf160Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. (1455 aa)
Cpsf5Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (237 aa)
eIF4G1Eukaryotic translation initiation factor 4G1 (eIF4G1) encodes a protein that contributes to translation and spermatogenesis. (1919 aa)
pcm5'-3' exoribonuclease 1; Pacman (pcm) encodes an exoribonuclease that degrades decapped mRNA. It is involved in epithelial closure, male fertility, apoptosis and growth control. (1613 aa)
WRNexoWerner Syndrome-like exonuclease; WRN exonuclease (WRNexo) encodes a 3'-5' exonuclease that cleaves 3' ends of both single-stranded and duplex DNA substrates that resemble DNA structures present during DNA replication. It may act in concert with RecQ family helicases to resolve Holliday junctions or other unusual DNA structures. It is likely to be involved in DNA replication, recombination and repair, and is essential for early embryonic development. (354 aa)
eIF4E6Eukaryotic translation initiation factor 4E6 (eIF4E6) encodes a RNA 7-methylguanosine cap binding protein. (173 aa)
eIF4AEukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation. (403 aa)
Gld2GLD2 poly(A) polymerase (Gld2) encodes a conserved poly-A polymerase in the GLD2 family. It is a paralog of the wisp gene. Gld2 is expressed strongly in the testis and at low levels in other tissues including the nervous system. In the male germ line, the product of Gld2 is essential for postmeiotic development of sperm; its depletion causes arrest of spermatogenesis prior to individualization, with abnormal nuclear condensation phenotypes. In the brain it is required for long-term memory. (1364 aa)
Cnot4CCR4-NOT transcription complex subunit 4 (Cnot4) encodes a positive regulator of the Jak/Stat pathway which acts by stabilizing the DNA binding of the product of Stat92E. (1062 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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