STRINGSTRING
Odc1 Odc1 Odc2 Odc2 Rpt1 Rpt1 Rpn13 Rpn13 Rpn2 Rpn2 Ate1 Ate1 nAChRalpha3 nAChRalpha3 Ubr1 Ubr1 agt agt nompC nompC Rpt6 Rpt6 Rpn10 Rpn10 Rpn5 Rpn5 Ubc6 Ubc6 Rpn9 Rpn9 Alg13 Alg13 Rpt6R Rpt6R His3:CG31613 His3:CG31613 Rpn6 Rpn6 Prosbeta5 Prosbeta5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Odc1Ornithine decarboxylase 1; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. (394 aa)
Odc2Ornithine decarboxylase 2; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. (393 aa)
Rpt126S proteasome regulatory complex subunit p48B; Regulatory particle triple-A ATPase 1 (Rpt1) encodes an AAA-type ATPase protein that forms part of the heterohexameric ATPase ring of the regulatory complex of the 26S proteasome. (433 aa)
Rpn13Proteasomal ubiquitin receptor ADRM1 homolog; May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome (By similarity). (424 aa)
Rpn226S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (1029 aa)
Ate1Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). (485 aa)
nAChRalpha3Nicotinic Acetylcholine Receptor alpha3 (nAChRalpha3) encodes a subunit of the nicotinic acetylcholine receptor, which is a pentameric neurotransmitter-gated ion channel. (795 aa)
Ubr1E3 ubiquitin-protein ligase UBR1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Belongs to the UBR1 family. (1824 aa)
agtO-6-alkylguanine-DNA alkyltransferase (agt) encodes a methylated-DNA-cysteine S-methyltransferase involved in DNA repair. (194 aa)
nompCNo mechanoreceptor potential C (nompC) encodes a pore-forming subunit for a mechanosensitive non-selective cation channel. It belongs to the TRP channel family and is expressed in peripheral sensory neurons. It senses gentle touch and regulates locomotion in larval body wall neurons. In the adult, the product of nompC is involved in hearing transduction in the Johnston's organ. (1761 aa)
Rpt626S proteasome regulatory subunit 8; Regulatory particle triple-A ATPase 6 (Rpt6) encodes a subunit of the proteasome, which is responsible for the ATP-dependent degradation of obsolete or damaged proteins. Rpt6 product belongs to the heterohexameric ring formed by triple-A ATPases that unfolds ubiquitinated target proteins before their degradation. (405 aa)
Rpn10Regulatory particle non-ATPase 10 (Rpn10) encodes one of the polyubiquitin receptor subunits of the 26S proteasome. It recognizes and binds the polyubiquitin moiety of proteins intended for proteasomal degradation or the ubiquitin-like domain of extraproteasomal ubiquitin receptors. (396 aa)
Rpn5Regulatory particle non-ATPase 5; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process. (502 aa)
Ubc6Ubiquitin-conjugating enzyme E2-17 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the putative E3 ligases poe, Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK ; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
Rpn926S proteasome regulatory complex subunit p39A; Structural molecule activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; proteasome assembly; proteasome-mediated ubiquitin-dependent protein catabolic process. (382 aa)
Alg13Glyco_tran_28_C domain-containing protein; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: dolichol-linked oligosaccharide biosynthetic process. (171 aa)
Rpt6RRegulatory particle triple-A ATPase 6-related; Hydrolase activity; TBP-class protein binding; ATP binding; ATPase activity. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of RNA polymerase II transcription preinitiation complex assembly; modulation of chemical synaptic transmission; Belongs to the AAA ATPase family. (399 aa)
His3:CG31613Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
Rpn626S proteasome non-ATPase regulatory subunit 11; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6 is required for proteasome assembly (By similarity). May act as linker between 19S regulatory subunit and the 20S proteasome core. (439 aa)
Prosbeta5Proteasome beta5 subunit (Prosbeta5) encodes an endopeptidase subunit of the of the 26S proteasome; Belongs to the peptidase T1B family. (282 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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