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Gr64d Gr64d Ir25a Ir25a TrpA1 TrpA1 Gr47a Gr47a Ir75b Ir75b Gr5a Gr5a Gr8a Gr8a Gr59b Gr59b Gr61a Gr61a Gr64a Gr64a Gr64f Gr64f ppk28 ppk28 Ir76b Ir76b Rh4 Rh4 Rh7 Rh7 Gr32a Gr32a Gr33a Gr33a ppk ppk ninaE ninaE Gr39a Gr39a Ir75c Ir75c Gr93a Gr93a Gr98b Gr98b Ir56d Ir56d trpl trpl Gr64e Gr64e ppk23 ppk23 Gr66a Gr66a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Gr64dGustatory receptor for sugar taste 64d; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily. (417 aa)
Ir25aIonotropic receptor 25a; Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection. Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b. Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool av [...] (947 aa)
TrpA1Transient receptor potential cation channel A1 (TrpA1) encodes a cation channel activated by warming and by reactive chemicals. Its roles include the control of thermotaxis at innocuous temperatures, as well as thermal and chemical nociception in response to noxious heat and chemical exposure. (1232 aa)
Gr47aGustatory receptor; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (361 aa)
Ir75bIonotropic receptor 75b; Ligand-gated ion channel activity; ionotropic glutamate receptor activity. It is involved in the biological process described with: detection of chemical stimulus involved in sensory perception. (605 aa)
Gr5aGustatory receptor 5a for trehalose; Gustatory receptor required for response to the sugar trehalose in taste neurons. Gr5a neurons selectively respond to sugars, in contrast to Gr66a cells which respond to bitter compounds. Flies are attracted to sugars and avoid bitter substances, suggesting that Gr5a neuron activity is sufficient to mediate acceptance behavior. Sugar signal transduction occurs through coupling with G-proteins such as Galpha49B and G-salpha60A. (444 aa)
Gr8aGustatory receptor 8a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing and avoiding L-canavanine, a plant-derived insecticide. (385 aa)
Gr59bGustatory receptor; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (366 aa)
Gr61aGustatory receptor for sugar taste 61a; One of the few identified sugar gustatory receptors identified so far with glucose being its primary ligand and which mediates acceptance behavior. (436 aa)
Gr64aGustatory receptor for sugar taste 64a; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily. (456 aa)
Gr64fGustatory receptor for sugar taste 64f; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64a to detect sucrose, maltose, and glucose. (469 aa)
ppk28Pickpocket protein 28; Osmosensitive ion channel that mediates the cellular and behavioral response to water. Plays an essential role in gustatory water reception. Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (606 aa)
Ir76bIonotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit. (636 aa)
Rh4Opsin Rh4; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (378 aa)
Rh7Rhodopsin 7 (Rh7) encodes a visual photoreceptor involved in circadian light entrainment. (483 aa)
Gr32aGustatory and pheromone receptor 32a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions as a pheromone receptor for a male inhibitory pheromone and promotes male-male aggression and suppresses male-male courtship. Also promotes preferentially virgin females courting over mated females. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily. (461 aa)
Gr33aGustatory and pheromone receptor 33a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing all nonvolatile repulsive chemicals, including tastants, pheromones, and especially N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions also as a pheromone receptor for a male inhibitory pheromone leading to male-male courtship suppression. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (475 aa)
ppkAmiloride-sensitive Na+ channel; Pickpocket (ppk) encodes an acid-sensing sodium channel from the degenerin/epithelial sodium channel (DEG/ENaC) family. It contributes to mechanical nociception, larval behavior and dendrite morphogenesis. (606 aa)
ninaEOpsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. (373 aa)
Gr39aGustatory and pheromone receptor 39a, isoform C; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Plays a role in sustaining courtship behavior in males, possibly through the reception of a stimulating arrestant pheromone. (381 aa)
Ir75cIonotropic glutamate receptor activity; signaling receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus involved in sensory perception. (623 aa)
Gr93aGustatory receptor for bitter taste 93a; Gustatory receptor required for response to the bitter in taste neurons. Gr93a cells respond to bitter compounds such as caffeine. Flies avoid bitter substances, suggesting that Gr93a neuron activity is sufficient to mediate avoidance behavior. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr93a subfamily. (419 aa)
Gr98bPutative gustatory receptor 98b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (403 aa)
Ir56dIonotropic receptor 56d; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (632 aa)
trplTransient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. (1124 aa)
Gr64eGustatory receptor for sugar taste 64e; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. confers responsiveness to glycerol and is required for feeding preference for beer and other sources that have fermenting yeast. (460 aa)
ppk23Pickpocket 23 (ppk23) encodes a gustatory-specific putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone perception and male courtship behavior. (591 aa)
Gr66aGustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...] (527 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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