STRINGSTRING
GluRIIA GluRIIA Moe Moe gbb gbb SNCF SNCF Syt4 Syt4 Tb Tb CG5984 CG5984 squ squ Syn Syn GluRIIE GluRIIE brp brp jbug jbug VGlut VGlut Sp1 Sp1 nSyb nSyb GluRIIC GluRIIC sqh sqh Act5C Act5C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GluRIIAGlutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (907 aa)
MoeMoesin/ezrin/radixin homolog 1; Involved in connections of major cytoskeletal structures to the plasma membrane. Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr. In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles. (649 aa)
gbbProtein 60A; Glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release. (455 aa)
SNCFSoxNeuro Co-Factor; Protein binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of localization. (146 aa)
Syt4Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment. (474 aa)
TbRE61793p; Structural constituent of chitin-based cuticle. It is involved in the biological process described with: chitin-based cuticle development; body morphogenesis. (283 aa)
CG5984Uncharacterized protein; Actin binding. It is involved in the biological process described with: actin cytoskeleton organization; cell differentiation. (271 aa)
squSquash, isoform A; Squash (squ) encodes a protein acting in the piRNA pathway that responds to transposase activity in the germline. (241 aa)
SynSynapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. (1041 aa)
GluRIIEGlutamate receptor IIE (GluRIIE) encodes an ion channel subunit involved in calcium ion transport. (897 aa)
brpBruchpilot, isoform J; Bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation. (2238 aa)
jbugJitterbug, isoform N; Jitterbug (jbug) encodes a Filamin-type protein. Filamins are actin crosslinkers that organize actin filaments into networks and connect them to membrane receptors. The product of jbug is required in photoreceptor cells for axon targeting and in notum tendon cells to maintain its shape during muscle-tendon interaction. (2990 aa)
VGlutVesicular glutamate transporter, isoform A. (632 aa)
Sp1Sp1, isoform F; Sp1 (Sp1) encodes a member of the Sp-family of Cys2His2-type zinc finger transcription factors. It is involved in ventral thoracic appendage specification, leg growth and in the development of type-II neuroblasts. (726 aa)
nSybNeuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. (206 aa)
GluRIICGlutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. (940 aa)
sqhSpaghetti squash (sqh) encodes the regulatory light chain of the nonmuscle type 2 myosin. Its phosphorylation through the Rho-Rho Kinase pathway is predicted to activate myosin motor activity. The product of sqh and myosin function in cellular processes such as cytokinesis, and also contribute to tissue morphogenesis. (174 aa)
Act5CActin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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