STRINGSTRING
Ir7f Ir7f Obp50c Obp50c Cyp6u1 Cyp6u1 Cyp6a22 Cyp6a22 Cyp6a16 Cyp6a16 Ir67a Ir67a Cyp4d14 Cyp4d14 Obp46a Obp46a Cyp4ad1 Cyp4ad1 mt:CoI mt:CoI Ir21a Ir21a Pld Pld Gr63a Gr63a Ir94f Ir94f ppk8 ppk8 Or19a Or19a Cyp4d1 Cyp4d1 Obp58b Obp58b Obp58d Obp58d Obp58c Obp58c Gr59a Gr59a Gr59d Gr59d Ir60a Ir60a Or63a Or63a ppk28 ppk28 Obp18a Obp18a Gr68a Gr68a Or67b Or67b GstO2 GstO2 Or22c Or22c Or22a Or22a Or22b Or22b Cyp28a5 Cyp28a5 ppk ppk Ugt301D1 Ugt301D1 Gr39a Gr39a Or85a Or85a Or85d Or85d Or85f Or85f Ugt302E1 Ugt302E1 Ugt302C1 Ugt302C1 Or88a Or88a Obp93a Obp93a Gr98a Gr98a Gr98b Gr98b Or98a Or98a ppk19 ppk19 Or42b Or42b Or42a Or42a ppk25 ppk25 Or56a Or56a Obp56b Obp56b GstE9 GstE9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ir7fIonotropic receptor 7f; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (621 aa)
Obp50cOdorant-binding protein 50c; Odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus. (185 aa)
Cyp6u1Probable cytochrome P450 6u1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (488 aa)
Cyp6a22Cytochrome P450 6a22; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (499 aa)
Cyp6a16Cyp6a16, isoform B; Monooxygenase activity; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; heme binding. It is involved in the biological process described with: oxidation-reduction process. (500 aa)
Ir67aIonotropic receptor 67a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (584 aa)
Cyp4d14Probable cytochrome P450 4d14; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (510 aa)
Obp46aOdorant-binding protein 46a; Odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus. (198 aa)
Cyp4ad1Probable cytochrome P450 4ad1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (516 aa)
mt:CoICytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (511 aa)
Ir21aIonotropic receptor 21a; Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in temperature (thermosensation). Together with Ir25a and Ir93a, mediates the response of the dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior ; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (842 aa)
PldPhospholipase; Phosphatidylinositol binding; phospholipase D activity. (1364 aa)
Gr63aGustatory and odorant receptor 63a; Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a. (489 aa)
Ir94fIonotropic receptor 94f; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (558 aa)
ppk8Pickpocket 8, isoform H; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (569 aa)
Or19aOdorant receptor 19a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the preference for citrus fruits for oviposition, especially through the response to valencene, the primary ligand of Or19a. Larvae growing on citrus fruits suffer a reduced risk of parasitism si [...] (387 aa)
Cyp4d1Cytochrome P450 4d1; Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (512 aa)
Obp58bOdorant-binding protein 58b; Odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus. (203 aa)
Obp58dOdorant-binding protein 58d; Odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus. (218 aa)
Obp58cOdorant-binding protein 58c; Odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus. (199 aa)
Gr59aGustatory receptor; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (367 aa)
Gr59dPutative gustatory receptor 59d; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (390 aa)
Ir60aIonotropic receptor 60a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (716 aa)
Or63aOdorant receptor 63a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butyl acetate, isoamyl acetate, and hexanoic acid. Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or63a subfamily. (420 aa)
ppk28Pickpocket protein 28; Osmosensitive ion channel that mediates the cellular and behavioral response to water. Plays an essential role in gustatory water reception. Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (606 aa)
Obp18aOdorant-binding protein 18a; Odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus. (128 aa)
Gr68aGustatory receptor 68a; Dsx-dependent essential component of pheromone-driven courtship behavior. Recognizes a female pheromone involved in the second step (tapping step) of the courtship display which is essential for efficient execution of the entire courtship sequence and timely mating. Required for detection of the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) and courtship suppression is mediated by the rele [...] (389 aa)
Or67bOdorant receptor 67b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate, pentyl acetate, methyl caproate, anisole, heptanal, 2-heptanone, r-carvone, nonanoic acid, and pyrazines. Belongs to the insect chemoreceptor superfamil [...] (421 aa)
GstO2Glutathione S transferase O2 (GstO2) encodes a protein involved in glutathione metabolism; Belongs to the GST superfamily. (251 aa)
Or22cOdorant receptor 22c; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (402 aa)
Or22aOdorant receptor 22a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses ethyl butyrate and to esters in more general. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally resp [...] (397 aa)
Or22bOdorant receptor 22b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses to esters. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. (397 aa)
Cyp28a5Probable cytochrome P450 28a5; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (505 aa)
ppkAmiloride-sensitive Na+ channel; Pickpocket (ppk) encodes an acid-sensing sodium channel from the degenerin/epithelial sodium channel (DEG/ENaC) family. It contributes to mechanical nociception, larval behavior and dendrite morphogenesis. (606 aa)
Ugt301D1UDP-glucuronosyltransferase; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity; Belongs to the UDP-glycosyltransferase family. (530 aa)
Gr39aGustatory and pheromone receptor 39a, isoform C; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Plays a role in sustaining courtship behavior in males, possibly through the reception of a stimulating arrestant pheromone. (381 aa)
Or85aOdorant receptor 85a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (397 aa)
Or85dPutative odorant receptor 85d; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (412 aa)
Or85fOdorant receptor 85f; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (392 aa)
Ugt302E1UDP-glucuronosyltransferase; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups; Belongs to the UDP-glycosyltransferase family. (521 aa)
Ugt302C1UDP-glycosyltransferase family 302 member C1; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups. It is involved in the biological process described with: UDP-glucose metabolic process. (528 aa)
Or88aOdorant receptor 88a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (401 aa)
Obp93aOdorant-binding protein 93a; Odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus. (196 aa)
Gr98aPutative gustatory receptor 98a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (391 aa)
Gr98bPutative gustatory receptor 98b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (403 aa)
Or98aOdorant receptor 98a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (397 aa)
ppk19Pickpocket 19 (ppk19) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family protein. In the larval stage, it is expressed in the terminal organ for salt taste and tracheal cells for liquid clearance. In the adult stage it functions in salt taste likely through its expression in the chemical-sensing epithelia in the leg segment and wing blade. (511 aa)
Or42bOdorant receptor 42b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate and pentyl acetate. (399 aa)
Or42aOdorant receptor 42a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanol, ethyl acetate, propyl acetate, and pentyl acetate. Responds also to pyrazines; Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor c [...] (406 aa)
ppk25Pickpocket 25 (ppk25) encodes a DEG/ENaC channel subunit involved in male courtship behavior and pheromone detection; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (451 aa)
Or56aOdorant receptor 56a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Specific receptor for geosmin, a microbial odorant that constitutes an ecologically relevant stimulus that alerts flies to the presence of harmful microbes and induces avoidance behavior. (419 aa)
Obp56bOdorant-binding protein 56b; Odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus; sensory perception of smell. (137 aa)
GstE9Putative glutathione S-transferase; Glutathione S transferase E9 (GstE9) encodes an enzyme involved in glutathione metabolic processes; Belongs to the GST superfamily. (221 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.