STRINGSTRING
rpr rpr Trxr-1 Trxr-1 Lsp1alpha Lsp1alpha Lsp2 Lsp2 Hsp23 Hsp23 S6k S6k apolpp apolpp betaTub56D betaTub56D GstE1 GstE1 NiPp1 NiPp1 Sod1 Sod1 GstD1 GstD1 Hsp22 Hsp22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rprCell death protein rpr; Reaper (rpr) encodes Reaper, Hid, Grim (RHG) protein. It contributes to the caspase dependent apoptosis by inhibiting the anti-apoptotic protein encoded by Diap1. (65 aa)
Trxr-1Thioredoxin reductase 1, mitochondrial; Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (596 aa)
Lsp1alphaLarval serum protein 1 alpha chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. (816 aa)
Lsp2Larval serum protein 2; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. (701 aa)
Hsp23Heat shock protein 23 (Hsp23) encodes a protein involved in protein folding. It contributes to the response to cold, heat and hypoxia. (186 aa)
S6kRibosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. (490 aa)
apolppApolipophorin-1; Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids. Also involved in the transport of hydrophobic ligands like juvenile hormones, pheromone hydrocarbons and carotenoids. Required for morphogens wingless (wg) and hedgehog (hh) function, probably by acting as vehicles for the movement of wg and hh, explaining how covalently lipidated wg and hh can spread over long distances. May also be involved in transport and/or metabolism of heme. (3351 aa)
betaTub56DTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
GstE1Glutathione S transferase E1 (GstE1) encodes an enzyme involved in glutathione metabolic processes and response to heat. (224 aa)
NiPp1Nuclear inhibitor of Protein phosphatase 1 (NiPp1) encodes a PP1 phosphatase inhibitor involved in axon guidance. (383 aa)
Sod1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
GstD1Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification. (209 aa)
Hsp22Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. (174 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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