node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GstD1 | GstE1 | FBpp0099824 | FBpp0085850 | Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification. | Glutathione S transferase E1 (GstE1) encodes an enzyme involved in glutathione metabolic processes and response to heat. | 0.714 |
GstD1 | Trxr-1 | FBpp0099824 | FBpp0071116 | Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification. | Thioredoxin reductase 1, mitochondrial; Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.630 |
GstD1 | betaTub56D | FBpp0099824 | FBpp0085721 | Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification. | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | 0.532 |
GstE1 | GstD1 | FBpp0085850 | FBpp0099824 | Glutathione S transferase E1 (GstE1) encodes an enzyme involved in glutathione metabolic processes and response to heat. | Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification. | 0.714 |
Hsp22 | Hsp23 | FBpp0100010 | FBpp0301282 | Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. | Heat shock protein 23 (Hsp23) encodes a protein involved in protein folding. It contributes to the response to cold, heat and hypoxia. | 0.580 |
Hsp23 | Hsp22 | FBpp0301282 | FBpp0100010 | Heat shock protein 23 (Hsp23) encodes a protein involved in protein folding. It contributes to the response to cold, heat and hypoxia. | Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. | 0.580 |
Lsp1alpha | Lsp2 | FBpp0073484 | FBpp0311507 | Larval serum protein 1 alpha chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. | Larval serum protein 2; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. | 0.987 |
Lsp2 | Lsp1alpha | FBpp0311507 | FBpp0073484 | Larval serum protein 2; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. | Larval serum protein 1 alpha chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. | 0.987 |
Lsp2 | apolpp | FBpp0311507 | FBpp0306689 | Larval serum protein 2; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. | Apolipophorin-1; Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids. Also involved in the transport of hydrophobic ligands like juvenile hormones, pheromone hydrocarbons and carotenoids. Required for morphogens wingless (wg) and hedgehog (hh) function, probably by acting as vehicles for the movement of wg and hh, explaining how covalently lipidated wg and hh can spread over long distances. May also be involved in transport and/or metabolism of heme. | 0.630 |
S6k | betaTub56D | FBpp0305462 | FBpp0085721 | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | 0.472 |
Sod1 | Trxr-1 | FBpp0075958 | FBpp0071116 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | Thioredoxin reductase 1, mitochondrial; Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.517 |
Sod1 | betaTub56D | FBpp0075958 | FBpp0085721 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | 0.472 |
Trxr-1 | GstD1 | FBpp0071116 | FBpp0099824 | Thioredoxin reductase 1, mitochondrial; Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification. | 0.630 |
Trxr-1 | Sod1 | FBpp0071116 | FBpp0075958 | Thioredoxin reductase 1, mitochondrial; Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | 0.517 |
apolpp | Lsp2 | FBpp0306689 | FBpp0311507 | Apolipophorin-1; Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids. Also involved in the transport of hydrophobic ligands like juvenile hormones, pheromone hydrocarbons and carotenoids. Required for morphogens wingless (wg) and hedgehog (hh) function, probably by acting as vehicles for the movement of wg and hh, explaining how covalently lipidated wg and hh can spread over long distances. May also be involved in transport and/or metabolism of heme. | Larval serum protein 2; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. | 0.630 |
betaTub56D | GstD1 | FBpp0085721 | FBpp0099824 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification. | 0.532 |
betaTub56D | S6k | FBpp0085721 | FBpp0305462 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. | 0.472 |
betaTub56D | Sod1 | FBpp0085721 | FBpp0075958 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. | 0.472 |