Protein argonaute-2; Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger; Belongs to the argonaute family. Ago subfamily.

Endoribonuclease Dcr-1; Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination; Belongs to the helicase family. Dicer subfamily.

Protein argonaute-2; Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger; Belongs to the argonaute family. Ago subfamily.

Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.

Protein argonaute-2; Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger; Belongs to the argonaute family. Ago subfamily.

Protein piwi; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner. [...]

Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha; Belongs to the ARS2 family.

Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. Has a role in oskar mRNA localization at the posterior pole of the developing oocyte.

Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha; Belongs to the ARS2 family.

Endoribonuclease Dcr-1; Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination; Belongs to the helicase family. Dicer subfamily.

Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha; Belongs to the ARS2 family.

Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; cell death; Belongs to the peptidase A1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

GH15170p; Cysteine-type endopeptidase activity. It is involved in the biological process described with: proteolysis involved in cellular protein catabolic process; Belongs to the peptidase C1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

RE02351p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: protein catabolic process; proteolysis; Belongs to the peptidase A1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

MIP16848p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: eggshell chorion assembly; cell death; protein catabolic process; proteolysis; Belongs to the peptidase A1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

Uncharacterized protein, isoform A; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; cell death; eggshell chorion assembly; Belongs to the peptidase A1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

IP19042p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; cell death; Belongs to the peptidase A1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

LP12231p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; cell death; protein catabolic process; Belongs to the peptidase A1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: protein catabolic process; proteolysis; Belongs to the peptidase A1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

Cathepsin L heavy chain; Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion; Belongs to the peptidase C1 family.

Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.

CathD, isoform A; cathD (cathD) encodes a protein involved in apoptosis and the defense response to Gram-negative bacteria; Belongs to the peptidase A1 family.