node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ace | Akt1 | FBpp0082248 | FBpp0082682 | Acetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | 0.413 |
Ace | CG4757 | FBpp0082248 | FBpp0307203 | Acetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. | Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family. | 0.920 |
Akt1 | Ace | FBpp0082682 | FBpp0082248 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Acetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. | 0.413 |
Akt1 | Ho | FBpp0082682 | FBpp0081900 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. | 0.682 |
Akt1 | Keap1 | FBpp0082682 | FBpp0082864 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. | 0.792 |
Akt1 | Lamp1 | FBpp0082682 | FBpp0085251 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. | 0.562 |
Akt1 | Ldh | FBpp0082682 | FBpp0304375 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Lactate dehydrogenase (Ldh) encodes a protein involved in myoblast fusion and somatic muscle development; Belongs to the LDH/MDH superfamily. LDH family. | 0.613 |
Akt1 | Nos | FBpp0082682 | FBpp0079777 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | Nitric oxide synthase; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3- isoform 6) are able to form intracellular complexes with the full- length protein and serve as dominant negative inhibitors of the enzyme activity; Belongs to the NOS family. | 0.656 |
CG4757 | Ace | FBpp0307203 | FBpp0082248 | Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family. | Acetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. | 0.920 |
Ho | Akt1 | FBpp0081900 | FBpp0082682 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | 0.682 |
Ho | Keap1 | FBpp0081900 | FBpp0082864 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. | Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. | 0.800 |
Ho | Nos | FBpp0081900 | FBpp0079777 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. | Nitric oxide synthase; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3- isoform 6) are able to form intracellular complexes with the full- length protein and serve as dominant negative inhibitors of the enzyme activity; Belongs to the NOS family. | 0.429 |
Keap1 | Akt1 | FBpp0082864 | FBpp0082682 | Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | 0.792 |
Keap1 | Ho | FBpp0082864 | FBpp0081900 | Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. | 0.800 |
Keap1 | Pink1 | FBpp0082864 | FBpp0099833 | Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. | 0.683 |
Lamp1 | Akt1 | FBpp0085251 | FBpp0082682 | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | 0.562 |
Lamp1 | Pink1 | FBpp0085251 | FBpp0099833 | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. | 0.640 |
Ldh | Akt1 | FBpp0304375 | FBpp0082682 | Lactate dehydrogenase (Ldh) encodes a protein involved in myoblast fusion and somatic muscle development; Belongs to the LDH/MDH superfamily. LDH family. | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | 0.613 |
Nos | Akt1 | FBpp0079777 | FBpp0082682 | Nitric oxide synthase; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3- isoform 6) are able to form intracellular complexes with the full- length protein and serve as dominant negative inhibitors of the enzyme activity; Belongs to the NOS family. | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] | 0.656 |
Nos | Ho | FBpp0079777 | FBpp0081900 | Nitric oxide synthase; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3- isoform 6) are able to form intracellular complexes with the full- length protein and serve as dominant negative inhibitors of the enzyme activity; Belongs to the NOS family. | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. | 0.429 |