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abd-A abd-A Prp40 Prp40 Clp Clp Wdr33 Wdr33 Rpb3 Rpb3 RnpS1 RnpS1 rump rump hth hth SF1 SF1 CstF64 CstF64 Cpsf73 Cpsf73 fus fus TBPH TBPH Cpsf160 Cpsf160 eIF4G1 eIF4G1 Srrm234 Srrm234 Rbfox1 Rbfox1 Nrg Nrg fne fne Dscam1 Dscam1 elav elav unc-13 unc-13 Rbp9 Rbp9 psq psq snRNP-U1-70K snRNP-U1-70K lola lola pre-lola-G pre-lola-G
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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abd-AHomeobox protein abdominal-A; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for segmental identity of the second through eighth abdominal segments. Once a pattern of abd-A expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments. Appears to repress expression of Ubx whenever they appear in the same cell, but abd-A is repressed [...] (590 aa)
Prp40LD24714p; RNA binding. It is involved in the biological process described with: mRNA cis splicing, via spliceosome; mRNA splicing, via spliceosome. (806 aa)
ClpCleavage and polyadenylation specificity factor subunit 4; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity. Binds RNA polymers with a preference for G- and/or C-rich clusters. Binds single-stranded DNA non-specifically. (296 aa)
Wdr33WD repeat domain 33, isoform A; It is involved in the biological process described with: mRNA polyadenylation. (807 aa)
Rpb3RNA polymerase II 33kD subunit; DNA-directed 5'-3' RNA polymerase activity; RNA polymerase II activity; protein dimerization activity; DNA binding. It is involved in the biological process described with: transcription by RNA polymerase II; cellular response to heat. (275 aa)
RnpS1RNA-binding protein S1 (RnpS1) encodes a protein involved in RNA splicing and regulation of DNA transposition. (374 aa)
rumpRumpelstiltskin, isoform A; Rumpelstiltskin (rump) encodes the Drosophila hnRNP M homolog. It binds to nos and osk mRNAs and plays a role in mRNA localization to the germ plasm by diffusion/entrapment during late stages of oogenesis. It also binds to exonic splicing enhancers on pre-mRNA targets, implicating it as a splicing factor. (632 aa)
hthHomeobox protein homothorax; All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt [...] (487 aa)
SF1Splicing factor 1, isoform A; Zinc ion binding; pre-mRNA branch point binding; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (787 aa)
CstF64Cleavage stimulation factor 64 kD subunit (CstF64) encodes an RNA-binding protein that is part of the cleavage stimulation factor (CstF) complex. As part of the CstF complex, it interacts with the polyadenylation protein encoded bysu(f). The product of CstF64 is necessary for the cleavage and polyadenylation of most mRNAs and for 3' end processing of mRNAs that encode the replication-dependent histones. (419 aa)
Cpsf73Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] (684 aa)
fusRNA-binding protein fusilli; mRNA splicing factor that regulates alternative splicing od specific genes. Has a maternal role in embryonic dorsal-ventral patterning; such role is probably indirect and due to its function as mRNA splicing factor regulator. (967 aa)
TBPHTAR DNA-binding protein-43 homolog (TBPH) encodes an RNA-binding protein that belongs to the hnRNP family. It contributes to synaptic growth of motor neurons and glial wrapping. (531 aa)
Cpsf160Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. (1455 aa)
eIF4G1Eukaryotic translation initiation factor 4G1 (eIF4G1) encodes a protein that contributes to translation and spermatogenesis. (1919 aa)
Srrm234Uncharacterized protein, isoform F; It is involved in the biological process described with: mRNA splicing, via spliceosome; alternative mRNA splicing, via spliceosome. (1655 aa)
Rbfox1RNA-binding Fox protein 1 (Rbfox1) encodes RNA-binding proteins that bind to (U)GCAUG elements. Nuclear isoforms of the product of Rbfox1 regulate tissue specific alternative splicing, while cytoplasmic isoforms regulate mRNA translation. It functions in a number of processes, including germline cyst development. (962 aa)
NrgNeuroglian; The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. (1309 aa)
fneFound in neurons (fne) encodes an RNA binding protein that works as a post-transcriptional regulator. It is present in the cytoplasm of all neurons. Lack of fne produces fusion of the mushroom body beta-lobes and altered male courtship behaviour. (356 aa)
Dscam1Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. (2038 aa)
elavProtein elav; Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism. Belongs to the RRM elav family. (483 aa)
unc-13Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis. (3186 aa)
Rbp9RNA-binding protein 9, isoform J; RNA-binding protein 9 (Rbp9) encodes a putative RNA binding protein involved in the establishment of the blood-brain barrier and control of germ cell proliferation. (684 aa)
psqPipsqueak, isoform M; Pipsqueak (psq) encodes a transcription factor that regulates chromatin silencing. It mediates the interaction of Polycomb group (Pc-G) members with Pc-G response elements. (1123 aa)
snRNP-U1-70KSmall ribonucleoprotein particle U1 subunit 70K (snRNP-U1-70K) encodes a protein component of the U1 snRNP. The U1 snRNP combines with other snRNPs on the pre-mRNA to assemble a spliceosome. (448 aa)
lolaLongitudinals lacking protein, isoforms F/I/K/T; Longitudinals lacking (lola) encodes a protein involved in Notch signaling, cell death, regulation of retrotransposons and expression of axon and dendrite patterning genes. It contributes to oogenesis, spermatogenesis, neural wiring, eye development and a variety of behaviors. (970 aa)
pre-lola-GLongitudinals lacking protein, isoform G; Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo. (436 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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