(17 nodes) (2023) Pyruvate kinase is post-translationally regulated by sirtuin 2 in Aedes aegypti mosquitoes. network (Drosophila melanogaster)

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Your Input:
	Pglym78	Phosphoglyceromutase 78 (Pglym78) encodes an enzyme involved in myoblast fusion and somatic muscle development; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (255 aa)
	porin	Voltage-dependent anion-selective channel; Porin (porin) encodes a beta-barrel channel protein localized in the outer membrane of mitochondria that conducts translocation of various ions and metabolites between cytoplasm and mitochondria. It plays roles in mitochondria dynamics and mitophagy, and is ubiquitinated by the E3 ligases encoded by park and Mul1. (282 aa)
	Sirt6	Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. (325 aa)
	Jra	Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Plays a role in dorsal closure. Belongs to the bZIP family. Jun subfamily. (372 aa)
	CG7362	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process. (793 aa)
	Sirt2	NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily. (355 aa)
	CG7059	Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (267 aa)
	Sirt7	NAD-dependent protein deacetylase Sirt7; NAD-dependent protein deacetylase. (771 aa)
	dare	NADPH:adrenodoxin oxidoreductase, mitochondrial; Defective in the avoidance of repellents (dare) encodes an enzyme associated with steroid hormone synthesis and required for normal olfactory behavior. Some mutants show widespread degeneration of adult nervous system; Belongs to the ferredoxin--NADP reductase type 1 family. (466 aa)
	Sirt4	NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. (312 aa)
	CG12229	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process. (571 aa)
	CG2964	Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process. (554 aa)
	CG11249	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process. (642 aa)
	Sirt1	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa)
	Pglym87	Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (292 aa)
	PyK	Pyruvate kinase (PyK) encodes an enzyme involved in muscle development, glycolysis and glucose homeostasis; Belongs to the pyruvate kinase family. (533 aa)
	CG7069	Pyruvate kinase activity; potassium ion binding; magnesium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process. (744 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG11249	CG12229	FBpp0078083	FBpp0074988	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process.	0.919
CG11249	CG2964	FBpp0078083	FBpp0077406	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process.	0.913
CG11249	CG7059	FBpp0078083	FBpp0083616	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.556
CG11249	CG7069	FBpp0078083	FBpp0083612	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	Pyruvate kinase activity; potassium ion binding; magnesium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process.	0.905
CG11249	CG7362	FBpp0078083	FBpp0304089	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	0.908
CG11249	Pglym78	FBpp0078083	FBpp0084753	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	Phosphoglyceromutase 78 (Pglym78) encodes an enzyme involved in myoblast fusion and somatic muscle development; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.673
CG11249	Pglym87	FBpp0078083	FBpp0082089	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.599
CG11249	PyK	FBpp0078083	FBpp0083611	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	Pyruvate kinase (PyK) encodes an enzyme involved in muscle development, glycolysis and glucose homeostasis; Belongs to the pyruvate kinase family.	0.900
CG12229	CG11249	FBpp0074988	FBpp0078083	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process.	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	0.919
CG12229	CG2964	FBpp0074988	FBpp0077406	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process.	Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process.	0.928
CG12229	CG7059	FBpp0074988	FBpp0083616	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process.	Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.620
CG12229	CG7069	FBpp0074988	FBpp0083612	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process.	Pyruvate kinase activity; potassium ion binding; magnesium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process.	0.909
CG12229	CG7362	FBpp0074988	FBpp0304089	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process.	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	0.916
CG12229	Pglym78	FBpp0074988	FBpp0084753	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process.	Phosphoglyceromutase 78 (Pglym78) encodes an enzyme involved in myoblast fusion and somatic muscle development; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.652
CG12229	Pglym87	FBpp0074988	FBpp0082089	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process.	Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.611
CG12229	PyK	FBpp0074988	FBpp0083611	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process.	Pyruvate kinase (PyK) encodes an enzyme involved in muscle development, glycolysis and glucose homeostasis; Belongs to the pyruvate kinase family.	0.911
CG2964	CG11249	FBpp0077406	FBpp0078083	Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process.	Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process.	0.913
CG2964	CG12229	FBpp0077406	FBpp0074988	Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process.	AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process.	0.928
CG2964	CG7059	FBpp0077406	FBpp0083616	Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process.	Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.573
CG2964	CG7069	FBpp0077406	FBpp0083612	Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process.	Pyruvate kinase activity; potassium ion binding; magnesium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process.	0.913