STRINGSTRING
Adh Adh CG18814 CG18814 Lsp2 Lsp2 PGRP-LE PGRP-LE agt agt imd imd Lsp1beta Lsp1beta Lsp1gamma Lsp1gamma Lsp1alpha Lsp1alpha CG18179 CG18179 spz spz RpL32 RpL32 PGRP-LC PGRP-LC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AdhAlcohol dehydrogenase (Adh) encodes an alcohol and acetaldehyde dehydrogenase involved in alcohol and acetaldehyde metabolism. (256 aa)
CG18814Alcohol dehydrogenase (NAD+) activity. It is involved in the biological process described with: oxidation-reduction process; alcohol metabolic process. (267 aa)
Lsp2Larval serum protein 2; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. (701 aa)
PGRP-LEPeptidoglycan-recognition protein LE; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram- negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is req [...] (345 aa)
agtO-6-alkylguanine-DNA alkyltransferase (agt) encodes a methylated-DNA-cysteine S-methyltransferase involved in DNA repair. (194 aa)
imdProtein immune deficiency; Essential for the imd/NF-kappa-B (Imd) humoral and epithelial immune response to Gram-negative bacteria. Functions as an adapter protein that transduces immunity signals from the activation of pathogen recognition receptors (PRRs) by bacterial infection to the Imd signaling pathway. Binding of diaminopimelic acid-type (DAP-type) bacterial peptidoglycans (PGN) causes multimerization or clustering of PGRP receptors which activate the Imd cascade probably by recruiting imd, Fadd and Dredd to the receptor complex. Once in proximity, Dredd cleaves imd in a Fadd-de [...] (273 aa)
Lsp1betaLarval serum protein 1 beta chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. (789 aa)
Lsp1gammaLarval serum protein 1 gamma chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. (772 aa)
Lsp1alphaLarval serum protein 1 alpha chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. (816 aa)
CG18179RE53819p; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. (268 aa)
spzProtein spaetzle C-106; Spatzle (spz) encodes a secreted protein which, after cleavage by an extracellular serine protease (encoded by ea or SPE), can induce the dimerization of the product of Tl, and the subsequent activation of the Toll pathway. It contributes to function of the Toll signaling cascade, which plays a key role in various developmental and immune processes, notably embryonic dorso-ventral patterning and regulation of antimicrobial peptides. (326 aa)
RpL3260S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
PGRP-LCPeptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] (520 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.