12 items (Drosophila melanogaster) - STRING interaction network

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	SrpRalpha	Signal recognition particle receptor subunit alpha homolog; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May have a role in axonogenesis. (614 aa)
	Epac	Exchange protein directly activated by cAMP (Epac) encodes a guanine nucleotide exchange factor for the Ras-like small GTPases encoded by Rap1 and Rap2l. It is involved in transducing cAMP effects during synaptic potentiation, neuronal differentiation and renal secretion. (1006 aa)
	dind	Diamond, isoform A. (592 aa)
	GluRIIA	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (907 aa)
	Nmdar2	NMDA receptor 2, isoform C; Ligand-gated ion channel activity; signaling receptor activity; NMDA glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity. (1083 aa)
	GluRIIC	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. (940 aa)
	unc-13	Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis. (3186 aa)
	Pvr	Receptor protein-tyrosine kinase; PDGF- and VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (encoded by Pvf1, Pvf2 or Pvf3). It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner. (1577 aa)
	SA-2	Stromalin-2 (SA-2) encodes a paralog of the cohesin protein encoded by SA. It functions in the male meiosis-specific homolog pairing pathway. It is required to maintain homolog pairing and to ensure bi-orientation of homologs during meiosis I. (973 aa)
	Pka-C1	cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. (353 aa)
	Rab3	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. (220 aa)
	Pka-C2	ATP binding; protein serine/threonine kinase activity; cAMP-dependent protein kinase activity; protein kinase A regulatory subunit binding. It is involved in the biological process described with: protein kinase A signaling; peptidyl-serine phosphorylation. (354 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Epac	Pka-C1	FBpp0302889	FBpp0089382	Exchange protein directly activated by cAMP (Epac) encodes a guanine nucleotide exchange factor for the Ras-like small GTPases encoded by Rap1 and Rap2l. It is involved in transducing cAMP effects during synaptic potentiation, neuronal differentiation and renal secretion.	cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane.	0.862
Epac	Pka-C2	FBpp0302889	FBpp0085089	Exchange protein directly activated by cAMP (Epac) encodes a guanine nucleotide exchange factor for the Ras-like small GTPases encoded by Rap1 and Rap2l. It is involved in transducing cAMP effects during synaptic potentiation, neuronal differentiation and renal secretion.	ATP binding; protein serine/threonine kinase activity; cAMP-dependent protein kinase activity; protein kinase A regulatory subunit binding. It is involved in the biological process described with: protein kinase A signaling; peptidyl-serine phosphorylation.	0.861
GluRIIA	GluRIIC	FBpp0078739	FBpp0307912	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission.	0.835
GluRIIA	Nmdar2	FBpp0078739	FBpp0070276	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	NMDA receptor 2, isoform C; Ligand-gated ion channel activity; signaling receptor activity; NMDA glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity.	0.781
GluRIIA	Rab3	FBpp0078739	FBpp0087352	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	0.440
GluRIIA	unc-13	FBpp0078739	FBpp0300963	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis.	0.432
GluRIIC	GluRIIA	FBpp0307912	FBpp0078739	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission.	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	0.835
GluRIIC	Nmdar2	FBpp0307912	FBpp0070276	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission.	NMDA receptor 2, isoform C; Ligand-gated ion channel activity; signaling receptor activity; NMDA glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity.	0.755
GluRIIC	Rab3	FBpp0307912	FBpp0087352	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission.	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	0.516
Nmdar2	GluRIIA	FBpp0070276	FBpp0078739	NMDA receptor 2, isoform C; Ligand-gated ion channel activity; signaling receptor activity; NMDA glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity.	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	0.781
Nmdar2	GluRIIC	FBpp0070276	FBpp0307912	NMDA receptor 2, isoform C; Ligand-gated ion channel activity; signaling receptor activity; NMDA glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity.	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission.	0.755
Pka-C1	Epac	FBpp0089382	FBpp0302889	cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane.	Exchange protein directly activated by cAMP (Epac) encodes a guanine nucleotide exchange factor for the Ras-like small GTPases encoded by Rap1 and Rap2l. It is involved in transducing cAMP effects during synaptic potentiation, neuronal differentiation and renal secretion.	0.862
Pka-C1	Pka-C2	FBpp0089382	FBpp0085089	cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane.	ATP binding; protein serine/threonine kinase activity; cAMP-dependent protein kinase activity; protein kinase A regulatory subunit binding. It is involved in the biological process described with: protein kinase A signaling; peptidyl-serine phosphorylation.	0.939
Pka-C2	Epac	FBpp0085089	FBpp0302889	ATP binding; protein serine/threonine kinase activity; cAMP-dependent protein kinase activity; protein kinase A regulatory subunit binding. It is involved in the biological process described with: protein kinase A signaling; peptidyl-serine phosphorylation.	Exchange protein directly activated by cAMP (Epac) encodes a guanine nucleotide exchange factor for the Ras-like small GTPases encoded by Rap1 and Rap2l. It is involved in transducing cAMP effects during synaptic potentiation, neuronal differentiation and renal secretion.	0.861
Pka-C2	Pka-C1	FBpp0085089	FBpp0089382	ATP binding; protein serine/threonine kinase activity; cAMP-dependent protein kinase activity; protein kinase A regulatory subunit binding. It is involved in the biological process described with: protein kinase A signaling; peptidyl-serine phosphorylation.	cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane.	0.939
Rab3	GluRIIA	FBpp0087352	FBpp0078739	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	0.440
Rab3	GluRIIC	FBpp0087352	FBpp0307912	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission.	0.516
Rab3	unc-13	FBpp0087352	FBpp0300963	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis.	0.985
unc-13	GluRIIA	FBpp0300963	FBpp0078739	Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis.	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	0.432
unc-13	Rab3	FBpp0300963	FBpp0087352	Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis.	Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.	0.985