Homeotic protein antennapedia; Antennapedia (Antp) is the distal-most member of the Antennapedia complex; one of two Hox gene complexes. Antp encodes a sequence-specific homeodomain transcription factor, which is part of a developmental regulatory system that specifies segmental identity in the pro- and mesothorax. In adults Antp loss of function is associated with a transformation of leg into antenna while ectopic expression in the head is associated with antenna to leg and eye to wing transformations.

Developmental protein eyes absent; Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development. Required for the survival of eye progenitor cells at a critical stage in morphogenesis. Belongs to the HAD-like hydrolase superfamily. EYA family.

Allatostatin double C, isoform C; Hormone activity.

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.

Allatostatin double C, isoform C; Hormone activity.

Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions.

Allatostatin double C, isoform C; Hormone activity.

Ecdysis triggering hormone (ETH) encodes two peptides (DrmETH1 and DrmETH2) involved in ecdysis. ETH depletion leads to respiratory and behavioral deficits, unsuccessful ecdysis and lethality.

Allatostatin double C, isoform C; Hormone activity.

Corticotropin-releasing factor-like; FMRFamide (FMRFa) encodes a propeptide precursor that is processed to generate bioactive neuropeptides, many of which activate the G protein coupled receptor encoded by FMRFaR. Physiologically, FMRFa-encoded peptides contribute to neuromuscular physiology modulation and sleep regulation.

Allatostatin double C, isoform C; Hormone activity.

Glycoprotein hormone alpha 2 (Gpa2) encodes a protein that, when linked to the product of Gpb5, can activate the G protein-coupled receptor encoded by Lgr1.

Allatostatin double C, isoform C; Hormone activity.

Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...]

Allatostatin double C, isoform C; Hormone activity.

Partner of Bursicon (Pburs) encodes a cystine knot protein that dimerizes with the product of Burs to form the bursicon neurohormone that acts on the receptor encoded by rk. Bursicon neurohormone is released after adult emergence and is required for tanning and hardening of the cuticle and expansion of the wings.

Allatostatin double C, isoform C; Hormone activity.

Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep.

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.

Allatostatin double C, isoform C; Hormone activity.

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.

Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions.

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.

Ecdysis triggering hormone (ETH) encodes two peptides (DrmETH1 and DrmETH2) involved in ecdysis. ETH depletion leads to respiratory and behavioral deficits, unsuccessful ecdysis and lethality.

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.

Corticotropin-releasing factor-like; FMRFamide (FMRFa) encodes a propeptide precursor that is processed to generate bioactive neuropeptides, many of which activate the G protein coupled receptor encoded by FMRFaR. Physiologically, FMRFa-encoded peptides contribute to neuromuscular physiology modulation and sleep regulation.

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.

Glycoprotein hormone alpha 2 (Gpa2) encodes a protein that, when linked to the product of Gpb5, can activate the G protein-coupled receptor encoded by Lgr1.

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.

Allatostatins MIP; Ligand for the sex peptide receptor (SPR). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat. May also have a regulatory role in gut motility.

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.

Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...]

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.

Partner of Bursicon (Pburs) encodes a cystine knot protein that dimerizes with the product of Burs to form the bursicon neurohormone that acts on the receptor encoded by rk. Bursicon neurohormone is released after adult emergence and is required for tanning and hardening of the cuticle and expansion of the wings.

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.

Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep.

Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions.

Allatostatin double C, isoform C; Hormone activity.

Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions.

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings.