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betaTub56D betaTub56D GluRIA GluRIA Nmdar1 Nmdar1 GluRIIA GluRIIA Nup133 Nup133 Nup98-96 Nup98-96 Tm1 Tm1 Lam Lam LamC LamC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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betaTub56DTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
GluRIAGlutamate receptor 1; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Forms ligand-gated ion channels which are activated by kainate; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (991 aa)
Nmdar1Glutamate [NMDA] receptor subunit 1; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation. (997 aa)
GluRIIAGlutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (907 aa)
Nup133Nuclear pore complex protein Nup133; Probable component of the nuclear pore complex (NPC) (Probable). Plays a role in NPC assembly and/or maintenance. (1200 aa)
Nup98-96Nuclear pore complex protein Nup98-Nup96; Part of the nuclear pore complex (NPC). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1. Plays a role in nuclear mRNA export. Promotes cell antiviral response by upregulating FoxK-dependent antiviral gene transcription. In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways. In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression. [Nuclear pore comp [...] (1960 aa)
Tm1Tropomyosin-1, isoforms 9A/A/B; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction; Belongs to the tropomyosin family. (711 aa)
LamLamin Dm0; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane. In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle. (622 aa)
LamCLamin-C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (By similarity). In spermatocytes, regulates cytokinesis during meiosis. (640 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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