STRINGSTRING
Usp5 Usp5 Ack Ack CG15047 CG15047 Tdrd3 Tdrd3 Cbl Cbl CG8209 CG8209 CG31528 CG31528 CG10694 CG10694 CG5111 CG5111 ref(2)P ref(2)P CG15445 CG15445 par-1 par-1 FBgn0028372 FBgn0028372 CG13604 CG13604 Rad23 Rad23 Ubqn Ubqn rngo rngo Ubc4 Ubc4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Usp5Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 5 (Usp5) encodes an essential enzyme that cleaves unanchored lysine48-linked polyubiquitin chains. It is involved in photoreceptor differentiation, neuron pathfinding and apoptosis. (827 aa)
AckActivated Cdc42 kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1073 aa)
CG15047MIP23504p. (174 aa)
Tdrd3Tudor domain containing 3; RNA binding. It is involved in the biological process described with: mRNA processing. (836 aa)
CblCbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. (878 aa)
CG8209GM09977p; Nucleic acid binding. (331 aa)
CG31528FI07626p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process. (344 aa)
CG10694AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. (290 aa)
CG5111FI08017p; It is involved in the biological process described with: protein ubiquitination; regulation of ubiquitin-dependent protein catabolic process. (614 aa)
ref(2)PProtein ref(2)P; Required for selective autophagy activation by ubiquitinated proteins. Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs. (599 aa)
CG15445LD38858p; It is involved in the biological process described with: regulation of ubiquitin-dependent protein catabolic process. (618 aa)
par-1Par-1 (par-1) encodes a protein kinase involved in multiple processes, including microtubule cytoskeleton organization, axis specification and cell polarity. It regulates hippo signaling and osk mRNA localization. (1170 aa)
FBgn0028372Isopeptidase-T-3, isoform C. (561 aa)
CG13604Protein UBASH3A homolog; Phosphatase activity. It is involved in the biological process described with: dephosphorylation. (763 aa)
Rad23DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. (414 aa)
UbqnUbiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. (547 aa)
rngoRings lost (rngo) encodes a ubiquitin receptor that binds to ubiquitinated proteins via its ubiquitin-associated domain. It is an essential protein that is required for proper development of ring canals in the female germ line. (458 aa)
Ubc4Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (199 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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