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| | Gprk1 | G protein-coupled receptor kinase 1; Specifically phosphorylates the activated forms of G protein- coupled receptors; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (700 aa) |
| | AMPKalpha | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. (582 aa) |
| | Sik2 | Salt-inducible kinase 2 (Sik2) encodes a serine/threonine kinase that is activated by the product of Lkb1. It regulates lipid storage and energy homeostasis by controlling the activity of cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC). (1398 aa) |
| | Cdk7 | Cyclin-dependent kinase 7 (Cdk7) encodes a serine/threonine protein kinase whose activity depends on the regulatory subunits encoded by CycH and Mat1. This trimeric Cdk complex activates other Cdks by phosphorylation in their T-loop and is called Cdk activating kinase (CAK). CAK can also be part of TFIIH, where the product of Cdk7 phosphorylates different transcription substrates (e.g. CTD of Pol II). (353 aa) |
| | Nek2 | LD04361p; Nek2 (Nek2) encodes a Ser/Thr kinase belonging to the NIMA family of kinases. It regulates centrosome disjunction, bipolar spindle formation, and kinetochore microtubule dynamics during mitosis. It also participates in meiosis by regulating chromatin condensation events. (735 aa) |
| | Dsor1 | Dual specificity mitogen-activated protein kinase kinase dSOR1; Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (396 aa) |
| | Erk7 | Extracellular signal-regulated kinase 7; Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner. In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly. Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53. (916 aa) |
| | Cdk9 | Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control. (404 aa) |
| | gek | Serine/threonine-protein kinase Genghis Khan; Acts as a downstream effector for the regulation of actin polymerization by Cdc42. (1637 aa) |
| | Slik | Sterile20-like kinase (Slik) encodes a member of the Sterile-20 kinase family. It acts via Raf to promote cell proliferation in imaginal disc epithelia. Independently, Slik acts via the product of Moe to support epithelial integrity. (1703 aa) |
| | Hipk | Homeodomain interacting protein kinase (Hipk) encodes a protein that belongs to the DYRK family kinases. It can modulate signaling pathways including Wingless, Notch, Hippo, Hedgehog, JNK, and cell death. It plays roles in development, proliferation and patterning of many tissues, including the eye, wing, and the embryo. (1340 aa) |
| | msn | Misshapen, isoform A; Misshapen (msn) encodes a Sterile 20 MAP kinase kinase kinase. (1504 aa) |
| | hep | Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa) |
| | mbt | Serine/threonine-protein kinase PAK mbt; Involved in neurogenesis of the adult central nervous system, and together with Cdc42, regulates photoreceptor cell morphogenesis. Phosphorylates exogenous substrates when activated by Cdc42. (639 aa) |
| | Rok | Rho-associated protein kinase; Rho kinase (Rok) encodes a kinase that, when activated by the GTP form of the product of Rho1, phosphorylates and modulates cytoskeletal proteins, particularly myosin II. Dynamic regulation of this kinase in subcellular locales influences cell polarization, movement, and shape during interphase and mitosis. (1390 aa) |
| | fu | Serine/threonine-protein kinase fused; Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2. (805 aa) |
| | S6KL | S6 Kinase Like (S6KL) encodes a serine/threonine kinase that inhibits BMP signaling through facilitating degradation of the BMP receptor encoded by tkv. It inhibits neuromuscular junction growth and promotes synaptic endocytosis at the neuromuscular junctions; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (483 aa) |
| | polo | Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (576 aa) |
| | Pka-C3 | cAMP-dependent protein kinase catalytic subunit 3; Does not have an essential role in development. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (583 aa) |
| | Cdk8 | Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C- terminal domain) of th [...] (454 aa) |
| | Pkg21D | Protein kinase, cGMP-dependent at 21D (Pkg21D) encodes a Mg[+] dependent-kinase that is activated by cGMP. It contributes to somatic muscle development, salivary gland morphogenesis and epithelial fluid transport. (768 aa) |
| | Pitslre | Serine/threonine-protein kinase PITSLRE; Acts as a negative regulator of the normal cell cycle progression. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase (By similarity). (952 aa) |
| | Cdk12 | Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (1157 aa) |
| | SAK | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...] (769 aa) |
| | CG9222 | AT03158p; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation. (337 aa) |
| | ninaC | Neither inactivation nor afterpotential protein C; Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. Essential for the expression and stability of the rtp protein in the photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina. (1501 aa) |
| | CG4839 | LP05330p; ATP binding; cGMP-dependent protein kinase activity. It is involved in the biological process described with: protein phosphorylation. (1003 aa) |
| | Cdk1 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. (297 aa) |
| | aurB | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. (329 aa) |
| | p38b | P38b MAP kinase (p38b) encodes the serine/threonine kinase that constitutes MAP kinase signaling cascades. It is phosphorylated by MAPK kinases and phosphorylates various substrates that play roles in stress responses, immune responses and differentiation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa) |
| | grp | Serine/threonine-protein kinase grp; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase [...] (512 aa) |
| | lok | Ovarian-specific serine/threonine-protein kinase Lok; May have a role in germline establishment. (476 aa) |
| | Aduk | Another drosophila Unc-51-like kinase, isoform A; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; positive regulation of autophagosome assembly; autophagy. (520 aa) |
| | aurA | Aurora A (aurA) encodes a protein kinase required for proper neuroblast self-renewal by regulating assymmetric protein localization. It contributes to spindle orientation, centrosome separation and pole cell formation. (411 aa) |
| | Lk6 | Lk6 kinase (Lk6) encodes the single ortholog of MAPK signal integrating kinases, which are phosphorylated and activated by ERK. Lk6 product phosphorylates the protein encoded by eIF4E1 to influence translation initiation via formation of the eIF4F complex. (1142 aa) |
| | Lkb1 | Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. (567 aa) |
| | Akt1 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa) |
| | GckIII | Germinal centre kinase III (GckIII) encodes a serine/threonine kinase of the STE20 superfamily. It is the sole Drosophila germinal center kinase type 3 family member. Loss of GckIIII results in tube dilation defects that are specific to the terminal cells of the tracheal system. (642 aa) |
| | CG14305 | AT25266p; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation. (302 aa) |
| | fray | Frayed, isoform A; Frayed (fray) encodes a serine/threonine-protein kinase required for axonal ensheathment. It is activated via phosphorylation by the kinase encoded by Wnk. The product of fray contributes to regulating ion transport, canonical Wnt signaling and asymmetric cell division. (552 aa) |
| | gwl | Greatwall, isoform A; Greatwall (gwl) encodes a kinase required for mitosis and female meiosis. It phosphorylates the product of endos, which then acts as a stoichiometric inhibitor of the PP2A B-type adaptor subunit encoded by tws. (846 aa) |
| | Mekk1 | Mekk1, isoform B; Mekk1 (Mekk1) encodes a MAP kinase kinase kinase that regulates the stress response. It is required for resistance to several stresses, notably osmotic shock, and for the regulation of the activity of the product of Duox. (1571 aa) |
| | CG6800 | Cyclin-dependent protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. (302 aa) |
| | p38a | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. (366 aa) |
| | p38c | Putative mitogen-activated protein kinase 14C; P38c MAP kinase (p38c) encodes a protein involved in the stress and wound responses, regulating the expression of Duox and Ddc. (356 aa) |
| | niki | NimA-like kinase; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: chromosome segregation; protein phosphorylation. (841 aa) |
| | Pkc98E | Protein C kinase 98E (Pkc98E) encodes a serine-threonine protein kinase activated by calcium, membrane translocation and lipids (such as diacylglycerol and phorbol ester). Pkc98E product controls cytoskeleton by negatively regulating the F-actin bundling protein encoded by sn. (739 aa) |
| | wts | Serine/threonine-protein kinase Warts; Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activi [...] (1105 aa) |
| | Pka-C2 | ATP binding; protein serine/threonine kinase activity; cAMP-dependent protein kinase activity; protein kinase A regulatory subunit binding. It is involved in the biological process described with: protein kinase A signaling; peptidyl-serine phosphorylation. (354 aa) |
| | CG12069 | UT01108p; cAMP-dependent protein kinase activity; ATP binding. It is involved in the biological process described with: protein kinase A signaling; protein phosphorylation. (356 aa) |
| | gskt | Putative glycogen synthase kinase-3 homolog; Gasket (gskt) is a retro-transposed glycogen synthase kinase 3 gene, derived from sgg, that is required for male fertility. Like many genes retroposed from the X chromosome, it is highly expressed in the testis. (501 aa) |
| | Gprk2 | G protein-coupled receptor kinase 2 (Gprk2) encodes a member of a family of serine/threonine kinases that modulate G-protein coupled receptors. It is required for female fertility, normal egg shape, and normal egg cAMP levels. It is also implicated in Hedgehog signaling and olfactory rhythmicity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (714 aa) |
| | hppy | Happyhour, isoform A; Happyhour (hppy) encodes the Drosophila orthologue of MAP4K3, a Ser/Thr Kinase belonging to the Germinal Center Kinase I family of Ste20-related kinases. The function of hppy has being linked to the Egfr, Hippo and Tor signalling pathways. (1218 aa) |
| | inaC | Protein kinase C, eye isozyme; This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox- dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the [...] (700 aa) |
| | Pkc53E | Protein kinase C, brain isozyme; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (By similarity). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity). Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection ; Belongs to the prote [...] (679 aa) |
| | Cdk4 | Cyclin-dependent kinase 4 (Cdk4) encodes a protein that contributes to cell cycle progression and cell growth. It is involved in the regulation of JAK-STAT and TORC1 signalling pathways. (317 aa) |
| | Cdk5 | Cyclin-dependent kinase 5 (Cdk5) encodes a protein serine-threonine kinase of the cyclin-dependent kinase family whose activity is largely restricted to post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration. (294 aa) |
| | CG8485 | Uncharacterized protein, isoform A; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation. (860 aa) |
| | Cdc2rk | Cdc2-related kinase (Cdc2rk) encodes a kinase that might be involved in cell cycle regulation; Belongs to the protein kinase superfamily. (387 aa) |
| | CaMKI | Calmodulin binding; ATP binding; calmodulin-dependent protein kinase activity. It is involved in the biological process described with: protein phosphorylation. (405 aa) |
| | for | cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B; Foraging (for) encodes a serine/threonine kinase and a member of the protein kinase G family. For roles include feeding, locomotion, metabolism, development, olfactory habituation, learning and memory, stress, social behavior, as well as Malpighian tubule, heart, muscle and synaptic function. (1088 aa) |
| | sff | Sugar-free frosting (sff) encodes a protein involved in neuromuscular junction development and protein N-linked glycosylation. (861 aa) |
| | Pka-C1 | cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. (353 aa) |
| | Dyrk3 | Putative dual specificity tyrosine-phosphorylation-regulated kinase 3 homolog; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. (828 aa) |
| | CG17528 | Serine/threonine-protein kinase CG17528; ATP binding; calmodulin binding; protein serine/threonine kinase activity; calcium-dependent protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; peptidyl-serine phosphorylation; protein autophosphorylation; intracellular signal transduction; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (748 aa) |
| | Pkn | Serine/threonine-protein kinase N; Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion and transcription activation signaling processes (By similarity). Plays a role in regulating Rho-mediated dorsal closure during embryogenesis. (1501 aa) |
| | CG32944 | Uncharacterized protein, isoform F; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: intracellular signal transduction; peptidyl-serine phosphorylation. (576 aa) |
| | Tlk | Tousled-like kinase, isoform G; Tousled-like kinase (Tlk) encodes a serine/threonine kinase that acts in a cell cycle-dependent manner. It contributes to cell morphogenesis, cell migration and cell death through interactions with chromatin components. (1489 aa) |
| | Doa | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (2045 aa) |
| | CG42366 | Uncharacterized protein, isoform A; Protein kinase activity; MAP kinase activity; ATP binding. It is involved in the biological process described with: cilium assembly; intraciliary transport; intracellular signal transduction; protein phosphorylation; regulation of gene expression. (706 aa) |
| | Ask1 | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. (1363 aa) |
| | CaMKII | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. (531 aa) |
| | Cdk2 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (314 aa) |
| | mnb | Minibrain (mnb) encodes a Ser/Thr protein kinase of the DYRK subfamily. It interacts with several signaling pathways and it is involved in behavior, cell cycle, cytoskeleton dynamics, neural proliferation, neurogenesis, neuronal differentiation, synaptic plasticity, and tissue growth. (1047 aa) |
| | Atg1 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa) |
| | Drak | Death-associated protein kinase related (Drak) encodes a protein serine/threonine kinase belonging to the Death-associated protein kinase family. It promotes phosphorylation of the product of sqh at sites known to stimulate actomyosin contractility. Its main characterized function is to shape epithelial tissues during development. (674 aa) |
| | bt | Bent, isoform F; Bent (bt) encodes the protein Projectin, a large protein associated with myosin thick filaments in insect muscles that contributes to the stiffness of flight muscle. (8933 aa) |
| | KP78a | LP21052p1; Protein serine/threonine kinase activity; ATP binding; tau-protein kinase activity. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation; microtubule cytoskeleton organization. (705 aa) |
| | KP78b | KP78b, isoform A; ATP binding; tau-protein kinase activity; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; microtubule cytoskeleton organization; intracellular signal transduction. (604 aa) |
| | PhKgamma | Phosphorylase kinase gamma (PhKgamma) encodes a protein involved in gastrulation, embryonic mesoderm formation and adult leg musculature development. (560 aa) |
| | bsk | Stress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa) |
| | MAPk-Ak2 | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (359 aa) |
| | Tao | Serine/threonine-protein kinase Tao; Serine/threonine-protein kinase which regulates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein. In imaginal cells, pho [...] (1039 aa) |
| | Sik3 | ATP binding; protein serine/threonine kinase activity. (1471 aa) |
| | sqa | Spaghetti-squash activator (sqa) encodes a myosin light chain kinase-like protein. It is a substrate of the kinase encoded by Atg1 and is required for starvation-induced autophagy. (888 aa) |
| | aPKC | Atypical protein kinase C; Serine/threonine protein kinase which is required for apico- basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishmen [...] (958 aa) |
| | Pak3 | Non-specific serine/threonine protein kinase; Pak3 (Pak3) encodes a Ser/Thr kinase implicated in myoblast fusion, synapse development, wound healing and border cell migration. It functions downstream of the small Rac GTPases to regulate actin cytoskeletal organization. (583 aa) |
| | Eip63E | Ecdysone-induced protein 63E (Eip63E) encodes a cyclin-dependent kinase that interacts with the product of CycY. It contributes to embryogenesis, larval development and metamorphosis. (538 aa) |
| | par-1 | Par-1 (par-1) encodes a protein kinase involved in multiple processes, including microtubule cytoskeleton organization, axis specification and cell polarity. It regulates hippo signaling and osk mRNA localization. (1170 aa) |
| | PKD | Protein Kinase D (PKD) encodes a Ser/Thr kinase of the PKC family of Ca[2+]/calmodulin-dependent protein kinases. It regulates actin-dynamics by controlling the activity of the phosphatase encoded by ssh. (906 aa) |
| | CASK | Peripheral plasma membrane protein CASK; CASK (CASK) encodes a member of the MAGUK family of scaffolding proteins. In epithelial tissues, the product of CASK functions as an adhesion molecule involved in cell proliferation, cytoskeletal remodeling and cell migration. In neurons, the product of CASK serves as a scaffold for a number of signaling and transmembrane molecules and is involved in synaptic development and plasticity. (929 aa) |
| | sgg | Protein kinase shaggy; Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering c [...] (1168 aa) |
| | hpo | Serine/threonine-protein kinase hippo; Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the act [...] (669 aa) |
| | dop | Drop out (dop) encodes a microtubule-associated Ser/Thr (MAST) protein kinase. Among its potential substrates is the microtubule motor Dynein. The product of dop is required for membrane growth and polarity during cell formation in the early cleavage stage embryo. (2139 aa) |
| | trc | Serine/threonine-protein kinase tricorner; Has an important role, with fry, in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Affects cellular morphogenesis by regulating the expression of target genes that encode cytoskeleton-interacting proteins and not via the direct modification of the cytoskeleton. Maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons. Belongs to the protein kinase supe [...] (463 aa) |
| | CG4629 | Uncharacterized protein, isoform E; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. (570 aa) |
| | sti | Non-specific serine/threonine protein kinase; Sticky (sti) encodes a member of the AGC family of kinases that functions to regulate both actin-myosin-mediated cytokinesis and epigenetic gene silencing. (1858 aa) |
| | JIL-1 | Chromosomal serine/threonine-protein kinase JIL-1; Phosphorylates 'Ser-10' of histone H3. May regulate gene expression by establishing or maintaining the structure of more open chromatin regions. Also required for normal polytene chromosome structure, for oogenesis and for viability throughout development. Regulates the structure of polytene chromosomes in salivary glands. May phosphorylate 'Ser-1' of histone H2A. (1207 aa) |
| | nmo | Mitogen-activated protein kinase; Nemo (nmo) encodes an atypical proline-directed serine/threonine kinase with roles in numerous developmental processes, including ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed. It regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch, and is implicated in fly models of neurodegenerative diseases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (439 aa) |
| | Pdk1 | 3-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (836 aa) |
| | S6k | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. (490 aa) |
| | S6kII | Ribosomal protein S6 kinase II (S6kII) encodes a protein that functions as a downstream effector and regulator of the MAP kinase pathway. It is involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning. (911 aa) |
| | CG17698 | Uncharacterized protein, isoform F; Protein serine/threonine kinase activity; calcium ion binding; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. (694 aa) |
| | Pak | P21-activated kinase (Pak) encodes a serine/threonine effector kinase for the small GTPases Rac and the product of Cdc42 involved in cytoskeletal regulation. The product of Pak contributes to growth cone guidance, synaptic development, and epithelial morphogenesis in both the ovary and embryo. (840 aa) |
| | Strn-Mlck | Stretchin-Mlck, isoform U; Stretchin-Mlck (Strn-Mlck) encodes a complex locus producing many large protein isoforms, which likely regulate cytoskeletal dynamics in muscles. A shorter isoform is specifically expressed in indirect flight muscle, localizes to the thick filament and is required to prevent flight muscle hypercontraction. Strn-Mlck mutants cannot fly and show flight muscle atrophy. (8255 aa) |
| | Dyrk2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2; In vitro; can phosphorylate exogenous substrates on Ser and Thr residues. May have a physiological role in development being involved in cellular growth and differentiation. (757 aa) |
| | Nuak | Nuak1 ortholog, isoform I; Protein serine/threonine kinase activity; structural molecule activity; ATP binding. It is involved in the biological process described with: protein phosphorylation. (2556 aa) |
| | Pkcdelta | Putative protein kinase C delta type homolog; ATP binding; protein kinase C activity; protein serine/threonine kinase activity. It is involved in the biological process described with: peptidyl-serine phosphorylation; intracellular signal transduction; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1894 aa) |
| | CG7236 | Uncharacterized protein, isoform C; ATP binding; cyclin-dependent protein serine/threonine kinase activity; protein kinase activity. It is involved in the biological process described with: mitotic cytokinesis; protein phosphorylation. (438 aa) |
| | Prp4k | Uncharacterized protein, isoform C; Protein serine/threonine kinase activity; protein kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; mRNA splicing, via spliceosome; positive regulation of hippo signaling. (912 aa) |
| | CkIIalpha | Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. (336 aa) |
| | rl | Mitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (376 aa) |
